effect-maternal-aerobic-exercise-on-myocardial-cerebral

Effect of Maternal Aerobic Exercise on Myocardial and Cerebral Ischemia/Reperfusion Injury in Offspring of Hypertensive Rats

Hypertension-mediated organ damage (HMOD) affects vital organs such as the heart and brain, leading to adverse outcomes and posing a serious threat to ...

Beijing Sport University

Exercise-induced muscle damage (EIMD) is a common occurrence in athletes and can lead to delayed onset muscle soreness, reduced athletic performance, and an increased risk of secondary injury. EIMD is a complex process involving oxidative stress, inflammation, and various cellular signaling pathways. Timely and effective repair of the extracellular matrix (ECM) and plasma membrane (PM) damage is critical for recovery from EIMD. Recent studies have shown that the targeted inhibition of phosphatase and tension homolog (PTEN) in skeletal muscles can enhance the ECM environment and reduce membrane damage in Duchenne muscular dystrophy (DMD) mice. However, the effects of PTEN inhibition on EIMD are unknown. Therefore, the present study aimed to investigate the potential therapeutic effects of VO-OHpic (VO), a PTEN inhibitor, on EIMD symptoms and underlying mechanisms. Our findings indicate that VO treatment effectively enhances skeletal muscle function and reduces strength loss during EIMD by upregulating membrane repair signals related to MG53 and ECM repair signals related to the tissue inhibitor of metalloproteinases (TIMPs) and matrix metalloproteinase (MMPs). These results highlight the potential of pharmacological PTEN inhibition as a promising therapeutic approach for EIMD.

PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice.

The neurophysiological mechanisms by which exercise improves cognitive function have not been fully elucidated. A comprehensive and systematic review of current domestic and international neurophysiological evidence on exercise improving cognitive function was conducted from multiple perspectives. At the molecular level, exercise promotes nerve cell regeneration and synaptogenesis and maintains cellular development and homeostasis through the modulation of a variety of neurotrophic factors, receptor activity, neuropeptides, and monoamine neurotransmitters, and by decreasing the levels of inflammatory factors and other modulators of neuroplasticity. At the cellular level, exercise enhances neural activation and control and improves brain structure through nerve regeneration, synaptogenesis, improved glial cell function and angiogenesis. At the structural level of the brain, exercise promotes cognitive function by affecting white and gray matter volumes, neural activation and brain region connectivity, as well as increasing cerebral blood flow. This review elucidates how exercise improves the internal environment at the molecular level, promotes cell regeneration and functional differentiation, and enhances the brain structure and neural efficiency. It provides a comprehensive, multi-dimensional explanation of the neurophysiological mechanisms through which exercise promotes cognitive function.

[The neurophysiological mechanisms of exercise-induced improvements in cognitive function].

Utilizing wearable devices and high-throughput omics technologies, the study aimed to establish an intensity-specific human acute swimming exercise model and draw a swimming metabolome atlas to clarify the commonalities and specificities in a panoramic dynamic physiological response under different intensities.

Dynamic Metabolic Changes Driven by Exercise-Intensity in Acute Swimming.

Sex differences in exercise metabolism have been recognized for decades, but the molecular metabolic landscape in which men and women reach standardized physiological exhaustion criteria remains unexplored.

Article	Year
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice. International journal of molecular sciences\| PubMed ID: 37373102	2023
[The neurophysiological mechanisms of exercise-induced improvements in cognitive function]. Sheng li xue bao : [Acta physiologica Sinica]\| PubMed ID: 40566717	2025
Dynamic Metabolic Changes Driven by Exercise-Intensity in Acute Swimming. Medicine and science in sports and exercise\| PubMed ID: 40601479	2025
Sexual dimorphism in the serum metabolome following acute exhaustive exercise. Biology of sex differences\| PubMed ID: 41199406	2025

Baile Wu

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