Ming-Der Perng

Institute of Molecular Medicine, National Tsing Hua University

Affiliated withNational Tsing Hua University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell vi... Experimental cell research\| PubMed ID: 21756903	2011
The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 23530264	2013
Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation. ASN neuro\| PubMed ID: 24102621	2013
Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease. European journal of human genetics : EJHG\| PubMed ID: 24755947	2015
Granulocyte colony-stimulating factor reduces fibrosis in a mouse model of chronic pancreatitis. PloS one\| PubMed ID: 25551560	2014
Purification of Protein Chaperones and Their Functional Assays with Intermediate Filaments. Methods in enzymology\| PubMed ID: 26778558	2016
The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Molecular biology of the cell\| PubMed ID: 27798231	2016
αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments. Cell stress & chaperones\| PubMed ID: 28470624	2017
Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP. PloS one\| PubMed ID: 28700643	2017
Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model. BMC neurology\| PubMed ID: 28882119	2017
Rhinacanthin C Alleviates Amyloid- Fibrils' Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-, and Interferon- in Glial Cells. Oxidative medicine and cellular longevity\| PubMed ID: 29181126	2017
Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. eLife\| PubMed ID: 31682229	2019
Extract Prevents Cisplatin-Induced Myelotoxicity and . Oxidative medicine and cellular longevity\| PubMed ID: 32047579	2020
Recessively-Inherited Adult-Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 32374915	2020
Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 33908669	2021
Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment. Science translational medicine\| PubMed ID: 34788075	2021
A novel in-frame GFAP p.E138_L148del mutation in Type II Alexander disease with atypical phenotypes. European journal of human genetics : EJHG\| PubMed ID: 35246666	2022
Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments. Molecular biology of the cell\| PubMed ID: 35511821	2022
The Relationship between Obesity-Related Factors and Graves' Orbitopathy: A Pilot Study. Medicina (Kaunas, Lithuania)\| PubMed ID: 36556950	2022
Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption and Cognitive Impairment . Journal of Alzheimer's disease reports\| PubMed ID: 36777330	2023
Glial fibrillary acidic protein is pathologically modified in Alexander disease. The Journal of biological chemistry\| PubMed ID: 38782207	2024
Development of Fusion-Based Assay as a Drug Screening Platform for Nipah Virus Utilizing Baculovirus Expression Vector System. International journal of molecular sciences\| PubMed ID: 39201788	2024
Deletions in Glial Fibrillary Acidic Protein Leading to Alterations in Intermediate Filament Assembly and Network Formation. International journal of molecular sciences\| PubMed ID: 40076540	2025
Phenotypic and molecular characterization of a recurrent SPTAN1 mutation causing SPG91. Molecular biology reports\| PubMed ID: 40397273	2025