an-advanced-co-culture-model-human-blood-cerebrospinal-fluid-barrier

An Advanced Co-Culture Model of the Human Blood-Cerebrospinal Fluid Barrier for Separate Analysis of Choroid Plexus Epithelium and Endothelium

The highly perfused choroid plexus (CP), located in the ventricular system of the brain, consists of several structural components, including a cuboid ...

Heidelberg University

Pulmonary recruitment and positive end-expiratory pressure (PEEP) titrated according to minimal static elastance of the respiratory system (PEEP) compared to PEEP set according to the ARDSNetwork table (PEEP) as a strategy to prevent ventilator-associated lung injury (VALI) in patients with acute respiratory distress syndrome (ARDS) increases mortality. Alternatively, avoiding negative end-expiratory transpulmonary pressure has been discussed as superior PEEP titration strategy. Therefore, we tested whether PEEP or PEEP prevent negative end-expiratory transpulmonary pressure in ARDS patients.

Positive end-expiratory pressure titrated according to respiratory system mechanics or to ARDSNetwork table did not guarantee positive end-expiratory transpulmonary pressure in acute respiratory distress syndrome.

Demographic change concurrent with medical progress leads to an increasing number of elderly patients in intensive care units (ICUs). Antibacterial treatment is an important, often life-saving, aspect of intensive care but burdened by the associated antimicrobial resistance risk. Elderly patients are simultaneously at greater risk of infections and may be more restrictively treated because, generally, treatment intensity declines with age. We therefore described utilization of antibacterials in ICU patients older and younger than 80 years and examined differences in the intensity of antibacterial therapy between both groups.

Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit.

Sepsis-3 definition uses SOFA score to discriminate sepsis from uncomplicated infection, replacing SIRS criteria that were criticized for being inaccurate. Eligibility of sepsis-3 criteria for sepsis diagnosis and the applied validation methodology using mortality as endpoint are topic of ongoing debate. We assessed the impact of different criteria on sepsis diagnosis in our ICU and devised a mathematical approach for mortality-based validation of sepsis criteria. As infectious status is often unclear at clinical deterioration, we integrated non-infected patients into analysis.

Impact of different consensus definition criteria on sepsis diagnosis in a cohort of critically ill patients-Insights from a new mathematical probabilistic approach to mortality-based validation of sepsis criteria.

The aim of this study was to establish quantitative CT (qCT) parameters for pathophysiological understanding and clinical use in patients with acute respiratory distress syndrome (ARDS). The most promising parameter is introduced.

A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome.

Intestinal ischemia is a common complication with obscure pathophysiology in critically ill patients. Since insufficient delivery of oxygen is discussed, we investigated the influence of oxygen delivery, hemoglobin, arterial oxygen saturation, cardiac index and the systemic vascular resistance index on the development of intestinal ischemia. Furthermore, we evaluated the predictive power of elevated lactate levels for the diagnosis of intestinal ischemia.

Maintaining oxygen delivery is crucial to prevent intestinal ischemia in critical ill patients.

Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in the critically ill commonly bases both outcome definition and predictions on clinical criteria for consensus definitions of sepsis, leading to circularity. As a remedy, we collected ground truth labels for sepsis.

Article	Year
Positive end-expiratory pressure titrated according to respiratory system mechanics or to ARDSNetwork table did not guarantee positive end-expiratory transpulmonary pressure in acute respira... Journal of critical care\| PubMed ID: 30336419	2018
Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit. BMC health services research\| PubMed ID: 31182082	2019
Impact of different consensus definition criteria on sepsis diagnosis in a cohort of critically ill patients-Insights from a new mathematical probabilistic approach to mortality-based valida... PloS one\| PubMed ID: 32898161	2020
A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome. PloS one\| PubMed ID: 33180805	2020
Maintaining oxygen delivery is crucial to prevent intestinal ischemia in critical ill patients. PloS one\| PubMed ID: 34242347	2021
Ground truth labels challenge the validity of sepsis consensus definitions in critical illness. Journal of translational medicine\| PubMed ID: 35033120	2022

Michael Hagmann

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