analysis-based-on-tcga-data-single-cell-data-taking-trpm4-as-an

Analysis Based on TCGA Data and Single-cell Data, taking <em>TRPM4</em> as an Example

In this article, an analysis method is introduced based on public transcriptomic datasets and single-cell datasets, which could be used to comprehensively ...

Nanjing Medical University

This review focuses on , a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in  that participate in bacterial colonization and immune responses. It is believed that outer membrane vesicles (OMVs) budding from the bacteria play a significant role in mediating bacterial survival and the subsequent attack against the host. Most OMVs originate from the bacterial membranes and molecules are enveloped in them. Elements similar to the pathogen endow OMVs with robust virulence, which provides a new direction for exploring the pathogenicity of  and its therapeutic pathways. Although extensive research has been carried out on the feasibility of OMV-based vaccines against pathogens, no study has yet summarized the bioactive elements, biological activity, and vaccine applicability of  OMVs. This review summarizes the components, biogenesis, and function of OMVs that contribute to their potential as vaccine candidates and the preparation methods and future directions for their development.

Outer Membrane Vesicles from : Biogenesis, Functions, and Vaccine Application.

Bladder cancer (BLCA) is one of the most invasive and malignant tumors in the world, thus leading to the urgent need of an accurate and recognizable biomarker. Several previous research has shown that Transient Receptor Potential Melastatin 4 (TRPM4) plays an important role in measuring vascular fragility and endothelial function. However, the role of TRPM4 in tumor hasn't been explored.

Article	Year
Outer Membrane Vesicles from : Biogenesis, Functions, and Vaccine Application. Vaccines\| PubMed ID: 38250862	2023
Transient Receptor Potential Melastatin 4 (TRPM4) is associated with an immuno-stimulatory TME and better prognosis in BLCA. Discover oncology\| PubMed ID: 41266683	2025

Zixu Chen

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