canertinib-as-an-flt3-inhibitor-with-potent-activity-against-flt3

Canertinib as an FLT3 Inhibitor with Potent Activity Against FLT3-Mutated and AC220-Resistant Acute Myeloid Leukemia

FMS-like tyrosine kinase 3 (FLT3) mutations are among the most common genetic lesions in acute myeloid leukemia (AML) and are frequently associated with ...

The First Affiliated Hospital of Soochow University

FLT3 mutations have been well-studied in acute myeloid leukemia (AML), and the detection of the FLT3 gene has become a clinical routine. However, it has not been fully analyzed in other hematologic malignancies, such as myelodysplastic syndromes (MDS).

The Role of FLT3-ITD Mutation on de Novo MDS in Chinese Population.

To detect and analyze the mutation status of FANCJ gene in adult AML patients, so as to provide the basis for studying the mechanism of FANCJ driven AML and guiding the preventim and treatment of deseese.

[Mutation Spectrum of FANCJ Gene in Adult Acute Myeloid Leukemia].

Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are frequent in acute myeloid leukemia (AML) and have important prognostic and therapeutic implications. FLT3 aberrations have been detected in a smaller fraction of acute lymphoblastic leukemia (ALL), and their prognostic value is not well established. We therefore assessed the FLT3 mutation in Chinese adolescent and adult ALL patients.

The Clinical and Molecular Characteristics of FLT3 Mutations in Chinese De Novo Adolescent and Adult Acute Lymphoblastic Leukemia Patients.

To assess changes of nutritional status by comprehensive nutrition assessment including nutritional risk screening, dietary assessment, blood biochemical index, and body composition in acute leukemia patients who had undergone chemotherapy.

[Observation of Nutritional Status Changes in Patients with Acute Leukemia During Chemotherapy].

Quantification of the FLT3 internal tandem duplication is a reliable marker for monitoring measurable residual disease in acute myeloid leukemia with FLT3-ITD mutations.

Article	Year
The Role of FLT3-ITD Mutation on de Novo MDS in Chinese Population. Clinical lymphoma, myeloma & leukemia\| PubMed ID: 30555035	2019
[Mutation Spectrum of FANCJ Gene in Adult Acute Myeloid Leukemia]. Zhongguo shi yan xue ye xue za zhi\| PubMed ID: 30998136	2019
The Clinical and Molecular Characteristics of FLT3 Mutations in Chinese De Novo Adolescent and Adult Acute Lymphoblastic Leukemia Patients. Clinical lymphoma, myeloma & leukemia\| PubMed ID: 32173273	2020
[Observation of Nutritional Status Changes in Patients with Acute Leukemia During Chemotherapy]. Zhongguo shi yan xue ye xue za zhi\| PubMed ID: 35981358	2022
Quantification of the FLT3 internal tandem duplication is a reliable marker for monitoring measurable residual disease in acute myeloid leukemia with FLT3-ITD mutations. Bone marrow transplantation\| PubMed ID: 39658655	2025

Chengqiao Qiu

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