Fajun Yang

Department of Medicine, Albert Einstein College of Medicine

Affiliated withAlbert Einstein College of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 21798740	2011
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. The Journal of clinical investigation\| PubMed ID: 22684109	2012
Mediating lipid biosynthesis: implications for cardiovascular disease. Trends in cardiovascular medicine\| PubMed ID: 23562092	2013
Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 . Journal of biochemical and pharmacological research\| PubMed ID: 23662249	2013
Regulation of SREBP-Mediated Gene Expression. Sheng Wu Wu Li Hsueh Bao\| PubMed ID: 23730104	2012
The Mediator Complex and Lipid Metabolism. Journal of biochemical and pharmacological research\| PubMed ID: 23795336	2013
Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells. The Journal of biological chemistry\| PubMed ID: 24142698	2013
The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity. PloS one\| PubMed ID: 24586592	2014
Inhibition of SREBP transcriptional activity by a boron-containing compound improves lipid homeostasis in diet-induced obesity. Diabetes\| PubMed ID: 24608444	2014
NRBF2 regulates macroautophagy as a component of Vps34 Complex I. The Biochemical journal\| PubMed ID: 24785657	2014
Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1). The Journal of biological chemistry\| PubMed ID: 25190802	2014
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PloS one\| PubMed ID: 26042770	2015
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. PLoS biology\| PubMed ID: 26222308	2015
Regulation of metabolism by the Mediator complex. Biophysics reports\| PubMed ID: 28018965	2016
Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α. The Journal of biological chemistry\| PubMed ID: 28351837	2017
Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma. The Journal of biological chemistry\| PubMed ID: 29514980	2018
The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis. Scientific reports\| PubMed ID: 29691438	2018
Regulation and Metabolic Significance of Lipogenesis in Adipose Tissues. Nutrients\| PubMed ID: 30274245	2018
The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity. The Journal of biological chemistry\| PubMed ID: 31028171	2019
Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms. The Journal of biological chemistry\| PubMed ID: 31270208	2019
Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges. International journal of molecular sciences\| PubMed ID: 31623194	2019
Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity. The Journal of biological chemistry\| PubMed ID: 32075912	2020
BF175 inhibits endometrial carcinoma through SREBP-regulated metabolic pathways in vitro. Molecular and cellular endocrinology\| PubMed ID: 33359761	2021
The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). Molecular metabolism\| PubMed ID: 33812059	2021
Comparative impact of dietary carbohydrates on the liver transcriptome in two strains of mice. Physiological genomics\| PubMed ID: 34643091	2021
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. Molecular metabolism\| PubMed ID: 35863637	2022
Complement C3 Reduces Apoptosis via Interaction with the Intrinsic Apoptotic Pathway. Cells\| PubMed ID: 37759504	2023
Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway. Nature communications\| PubMed ID: 38565851	2024
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states. Nature metabolism\| PubMed ID: 40281362	2025
Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice. The Journal of clinical investigation\| PubMed ID: 40454488	2025