Jeffrey E. Pessin

Department of Medicine, Albert Einstein College of Medicine

Affiliated withAlbert Einstein College of Medicine

Research Area

Biography

Jeffrey E. Pessin has not added Biography.
If you are Jeffrey E. Pessin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. Journal of cell science\| PubMed ID: 18505797	2008
Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice. The Journal of biological chemistry\| PubMed ID: 19064993	2009
The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. The Biochemical journal\| PubMed ID: 19076072	2009
Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway... The Journal of biological chemistry\| PubMed ID: 19122000	2009
Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate. Endocrinology\| PubMed ID: 19179444	2009
Insulin granule biogenesis, trafficking and exocytosis. Vitamins and hormones\| PubMed ID: 19251047	2009
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner. Endocrinology\| PubMed ID: 19477941	2009
Sarcoglycan complex: implications for metabolic defects in muscular dystrophies. The Journal of biological chemistry\| PubMed ID: 19494113	2009
Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity? Archives of physiology and biochemistry\| PubMed ID: 19728795	2009
Evidence that electrostatic interactions between vesicle-associated membrane protein 2 and acidic phospholipids may modulate the fusion of transport vesicles with the plasma membrane. Molecular biology of the cell\| PubMed ID: 19812247	2009
Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate. Traffic (Copenhagen, Denmark)\| PubMed ID: 19845918	2010
Autophagy regulates adipose mass and differentiation in mice. The Journal of clinical investigation\| PubMed ID: 19855132	2009
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. The Journal of clinical investigation\| PubMed ID: 19955654	2010
High basal cell surface levels of fish GLUT4 are related to reduced sensitivity of insulin-induced translocation toward GGA and AS160 inhibition in adipocytes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20075431	2010
Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell metabolism\| PubMed ID: 20142099	2010
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. The Journal of biological chemistry\| PubMed ID: 20308074	2010
Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice. Diabetes\| PubMed ID: 20876717	2011
Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance. Future medicinal chemistry\| PubMed ID: 21428801	2010
High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes\| PubMed ID: 21734017	2011
Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance. The Journal of biological chemistry\| PubMed ID: 21813649	2011
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22185839	2012
Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype. BoneKEy osteovision\| PubMed ID: 22241295	2009
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO reports\| PubMed ID: 22249165	2012
Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line. PloS one\| PubMed ID: 22276109	2012
Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice. The Journal of nutrition\| PubMed ID: 22437564	2012
Insulin-like growth factor axis and risk of type 2 diabetes in women. Diabetes\| PubMed ID: 22554827	2012
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. The Journal of clinical investigation\| PubMed ID: 22684109	2012
Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. Cell reports\| PubMed ID: 22745922	2012
Syntaxin4 interacting protein (Synip) binds phosphatidylinositol (3,4,5) triphosphate. PloS one\| PubMed ID: 22880106	2012
The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival. Diabetes\| PubMed ID: 22933109	2013
How does high-fat diet induce adipose tissue fibrosis? Journal of investigative medicine : the official publication of the American Federation for Clinical Research\| PubMed ID: 23072903	2012
Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes\| PubMed ID: 23321073	2013
Alterations in glucose homeostasis in a murine model of Chagas disease. The American journal of pathology\| PubMed ID: 23321322	2013
Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells. PloS one\| PubMed ID: 23383252	2013
Mechanisms for fiber-type specificity of skeletal muscle atrophy. Current opinion in clinical nutrition and metabolic care\| PubMed ID: 23493017	2013
Adipokines mediate inflammation and insulin resistance. Frontiers in endocrinology\| PubMed ID: 23781214	2013
Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes\| PubMed ID: 23801581	2013
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO reports\| PubMed ID: 23907538	2013
Skeletal muscle autophagy: a new metabolic regulator. Trends in endocrinology and metabolism: TEM\| PubMed ID: 24182456	2013
Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice. PloS one\| PubMed ID: 24312371	2013
The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity. PloS one\| PubMed ID: 24586592	2014
Dual mode action of mangiferin in mouse liver under high fat diet. PloS one\| PubMed ID: 24598864	2014
Inhibition of SREBP transcriptional activity by a boron-containing compound improves lipid homeostasis in diet-induced obesity. Diabetes\| PubMed ID: 24608444	2014
NRBF2 regulates macroautophagy as a component of Vps34 Complex I. The Biochemical journal\| PubMed ID: 24785657	2014
Recent progress in metabolic signaling pathways regulating aging and life span. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 24833582	2014
Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets. Diabetes\| PubMed ID: 24848064	2014
Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 25231351	2014
Geroscience: linking aging to chronic disease. Cell\| PubMed ID: 25417146	2014
Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway. Cell reports\| PubMed ID: 25466256	2014
The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice. Diabetes/metabolism research and reviews\| PubMed ID: 25613819	2015
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PloS one\| PubMed ID: 26042770	2015
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell\| PubMed ID: 26091038	2015
Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake. Endocrinology\| PubMed ID: 26200093	2015
Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death. The Journal of biological chemistry\| PubMed ID: 26306048	2015
Enhanced Glucose Transport, but not Phosphorylation Capacity, Ameliorates Lipopolysaccharide-Induced Impairments in Insulin-Stimulated Muscle Glucose Uptake. Shock (Augusta, Ga.)\| PubMed ID: 26682946	2016
Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models. Frontiers in physiology\| PubMed ID: 26733885	2015
Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers. Biomaterials science\| PubMed ID: 27152370	2016
Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy. Oncotarget\| PubMed ID: 27626315	2016
Transcription Factor EB Controls Metabolic Flexibility during Exercise. Cell metabolism\| PubMed ID: 28011087	2017
Regulation of metabolism by the Mediator complex. Biophysics reports\| PubMed ID: 28018965	2016
MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature\| PubMed ID: 28273060	2017
Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α. The Journal of biological chemistry\| PubMed ID: 28351837	2017
ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes. Scientific reports\| PubMed ID: 28765602	2017
[High frequency electrical stimulation of sciatic nerve enhances skeletal muscle autophagy in mice]. Sheng li xue bao : [Acta physiologica Sinica]\| PubMed ID: 28825100	2017
System-wide Benefits of Intermeal Fasting by Autophagy. Cell metabolism\| PubMed ID: 29107505	2017
Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages. Oncotarget\| PubMed ID: 29156823	2017
Mangiferin Accelerates Glycolysis and Enhances Mitochondrial Bioenergetics. International journal of molecular sciences\| PubMed ID: 29315239	2018
The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC. The Journal of biological chemistry\| PubMed ID: 29650758	2018
Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell metabolism\| PubMed ID: 29937374	2018
SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy. The Journal of clinical investigation\| PubMed ID: 30102258	2018
Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease. American journal of physiology. Renal physiology\| PubMed ID: 30280599	2018
The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity. The Journal of biological chemistry\| PubMed ID: 31028171	2019
Analysis of FAM19A2/TAFA-2 function. Physiology & behavior\| PubMed ID: 31220516	2019
Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity. Molecules (Basel, Switzerland)\| PubMed ID: 31979355	2020
SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes. JCI insight\| PubMed ID: 32051343	2020
Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity. The Journal of biological chemistry\| PubMed ID: 32075912	2020
FAM83G Is a Novel Inducer of Apoptosis. Molecules (Basel, Switzerland)\| PubMed ID: 32570757	2020
The Impact of Single-Cell Genomics on Adipose Tissue Research. International journal of molecular sciences\| PubMed ID: 32635651	2020
ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death. The Journal of biological chemistry\| PubMed ID: 32848017	2020
Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes. Developmental cell\| PubMed ID: 33667344	2021
The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). Molecular metabolism\| PubMed ID: 33812059	2021
Comparative impact of dietary carbohydrates on the liver transcriptome in two strains of mice. Physiological genomics\| PubMed ID: 34643091	2021
Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis. JCI insight\| PubMed ID: 34784301	2021
TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling. eLife\| PubMed ID: 35254259	2022
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. Molecular metabolism\| PubMed ID: 35863637	2022
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1. Nature communications\| PubMed ID: 36596796	2023
Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation. iScience\| PubMed ID: 37168570	2023
Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway. Nature communications\| PubMed ID: 38565851	2024
The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet. PLoS biology\| PubMed ID: 39436946	2024
Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice. Nature communications\| PubMed ID: 39856118	2025
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states. Nature metabolism\| PubMed ID: 40281362	2025
Widespread discordance between mRNA expression, protein abundance and lipogenesis activity in hepatocytes during the fed-starvation transition. bioRxiv : the preprint server for biology\| PubMed ID: 40376090	2025
Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice. The Journal of clinical investigation\| PubMed ID: 40454488	2025