ganzhirong-granule-inhibits-hepatic-gluconeogenesis-through-sirt3

Ganzhirong Granule Inhibits Hepatic Gluconeogenesis through the SIRT3-MPC1-PC/PDH Axis in Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is a global metabolic disorder characterized by hepatic insulin resistance and excessive gluconeogenesis. Ganzhirong ...

Changchun University of Chinese Medicine

the Affiliated Hospital to Changchun University of Chinese Medicine

This study investigated the synergistic repair effects of Prontosan hydrogel and carbon photon therapy in a rat full-thickness wound model.

Combined carbon photon and hydrogel therapy mediates the synergistic repair of full-thickness skin wounds.

Previous observational studies have demonstrated a link between diabetes mellitus(DM) and primary biliary cholangitis (PBC). Nevertheless, since these relationships might be confused, whether there is any causal connection or in which direction it exists is unclear. Our investigation aimed to identify the causal associations between DM and PBC.

Association between diabetes mellitus and primary biliary cholangitis: a two-sample Mendelian randomization study.

Cardiovascular disease (CVD) remains the leading cause of global mortality and disability. As an inevitable risk factor, cardiac aging significantly exacerbates the incidence and progression of age-related cardiovascular pathologies, including coronary artery disease, cardiomyopathies, and heart failure in the elderly population. Mitochondria function as central organelles in cardiac energy metabolism. Dysregulation of functional homeostasis, characterized by impaired quality control mechanisms, such as diminished energy production efficiency and exacerbated oxidative stress, is a primary driver of the cardiac aging process. Accumulating evidence in recent years indicates that sirtuin 1 (SIRT1) plays a crucial role in regulating cardiac aging. A range of therapeutic agents, including natural compounds and synthetic molecules, ameliorate cardiac aging and related pathologies by activating SIRT1 to modulate mitochondrial function. This review systematically summarizes the emerging roles of SIRT1 in cardiac aging, with a focus on the molecular mechanisms through which SIRT1 governs mitochondrial homeostasis. We also highlight recent advances in SIRT1-targeted therapeutic strategies, thereby providing a theoretical basis and translational perspectives for preventing and treating cardiac aging-related diseases.

Article	Year
Combined carbon photon and hydrogel therapy mediates the synergistic repair of full-thickness skin wounds. The Journal of international medical research\| PubMed ID: 32776863	2020
Association between diabetes mellitus and primary biliary cholangitis: a two-sample Mendelian randomization study. Frontiers in endocrinology\| PubMed ID: 38774228	2024
SIRT1-Mediated Mitochondrial Homeostasis in Cardiac Aging: Molecular Mechanisms and Therapeutic Implications. Aging and disease\| PubMed ID: 41135102	2025

Sitong Chen

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