Anil Chauhan

Department of Internal Medicine, University of Iowa

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis. Blood\| PubMed ID: 18083848	2008
ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood\| PubMed ID: 22123843	2012
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood\| PubMed ID: 22186991	2012
Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice. Stroke\| PubMed ID: 22363055	2012
ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 22712744	2012
ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice. Blood\| PubMed ID: 22983446	2012
Red blood cells mediate the onset of thrombosis in the ferric chloride murine model. Blood\| PubMed ID: 23343833	2013
Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. Circulation\| PubMed ID: 23426106	2013
Degradation of platelet-von Willebrand factor complexes by plasmin: an alternative/backup mechanism to ADAMTS13. Circulation\| PubMed ID: 24449820	2014
Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice. Blood\| PubMed ID: 25343959	2015
Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25675995	2015
Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4. Blood\| PubMed ID: 25700433	2015
Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26427793	2015
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26449752	2015
Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. Circulation\| PubMed ID: 26508731	2015
Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice. Thrombosis and haemostasis\| PubMed ID: 26790499	2016
Protein methionine oxidation augments reperfusion injury in acute ischemic stroke. JCI insight\| PubMed ID: 27294204	2016
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27444201	2016
P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 27943541	2017
ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28495930	2017
Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29326316	2018
Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29348121	2018
Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 29398531	2018
Deletion of Extra Domain A of Fibronectin Reduces Acute Myocardial Ischaemia/Reperfusion Injury in Hyperlipidaemic Mice by Limiting Thrombo-Inflammation. Thrombosis and haemostasis\| PubMed ID: 29960272	2018
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30093535	2018
Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis. Blood advances\| PubMed ID: 30108111	2018
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis. The Journal of experimental medicine\| PubMed ID: 30733282	2019
Fn-EDA (Fibronectin Containing Extra Domain A) in the Plasma, but Not Endothelial Cells, Exacerbates Stroke Outcome by Promoting Thrombo-Inflammation. Stroke\| PubMed ID: 30909835	2019
Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS pathogens\| PubMed ID: 31116795	2019
Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia. The Journal of clinical investigation\| PubMed ID: 31763999	2020
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 32144179	2020
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation. Circulation research\| PubMed ID: 32195632	2020
Low-Frequency Vibrations Enhance Thrombolytic Therapy and Improve Stroke Outcomes. Stroke\| PubMed ID: 32397935	2020
Differential Roles of Endothelial Cell-Derived and Smooth Muscle Cell-Derived Fibronectin Containing Extra Domain A in Early and Late Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 32434411	2020
Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling. Scientific reports\| PubMed ID: 32555351	2020
The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis. Blood\| PubMed ID: 33027814	2021
Cellular fibronectin promotes deep vein thrombosis in diet-induced obese mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 33300307	2021
Smooth Muscle Cell-Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 33691477	2021
Loss of diacylglycerol kinase ε causes thrombotic microangiopathy by impairing endothelial VEGFA signaling. JCI insight\| PubMed ID: 33986189	2021
Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling. JCI insight\| PubMed ID: 34027892	2021
Risk of Venous Thromboembolism in Hospitalized Patients with Acute Ischemic Stroke Versus Other Neurological Conditions. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 34500199	2021
PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke. Blood\| PubMed ID: 34529778	2022
Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 35106938	2022
Role of Integrins in Modulating Smooth Muscle Cell Plasticity and Vascular Remodeling: From Expression to Therapeutic Implications. Cells\| PubMed ID: 35203297	2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke\| PubMed ID: 35354299	2022
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis. Circulation research\| PubMed ID: 35400205	2022
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice. Cell & bioscience\| PubMed ID: 35619185	2022
Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. Experimental eye research\| PubMed ID: 36152913	2022
Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis. Blood advances\| PubMed ID: 36971790	2023
Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37061131	2023
Characterization of bleeding symptoms in Ehlers-Danlos syndrome. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37179130	2023
Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia. Stroke\| PubMed ID: 37449422	2023
Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm? Cardiovascular research\| PubMed ID: 37706546	2023
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science translational medicine\| PubMed ID: 37729432	2023
Uric Acid: A Translational Journey in Cerebroprotection That Spanned Preclinical and Human Data. Neurology\| PubMed ID: 37848338	2023
Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI-Stimulated Human Platelets-Brief Report. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 37942614	2024
Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice. Blood advances\| PubMed ID: 38838230	2024
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial. Circulation research\| PubMed ID: 39034919	2024
Genetic ablation of myeloid integrin α9 attenuates early atherosclerosis. Journal of leukocyte biology\| PubMed ID: 39036986	2024
Cerebroprotective action of butylphthalide in acute ischemic stroke: Potential role of Nrf2/HO-1 signaling pathway. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 39358173	2024
Imbalanced VWF-ADAMTS13 axis contributes to the detrimental impact of a preceding respiratory tract infection on stroke. Blood advances\| PubMed ID: 39787593	2025
Mitochondrial Ca uniporter b (MCUb) regulates neuronal Ca dynamics and resistance to ischemic stroke. Cell calcium\| PubMed ID: 40058292	2025
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial. Stroke\| PubMed ID: 40091742	2025
Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention. Blood\| PubMed ID: 40132161	2025
Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN Trial. Stroke\| PubMed ID: 40396268	2025
Multicenter SPAN Trial of Fasudil in Ischemic Stroke. Stroke\| PubMed ID: 40421536	2025
Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network. Stroke\| PubMed ID: 40899256	2025
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib. Journal of the American Heart Association\| PubMed ID: 40996065	2025
Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis. Blood advances\| PubMed ID: 41118613	2025
Methodological framework and unified metrics for thrombus resolution analysis in the mouse inferior vena cava stenosis model. Research and practice in thrombosis and haemostasis\| PubMed ID: 41169535	2025
The mitochondrial calcium uniporter regulates calcium dynamics to drive platelet function, bioenergetics, and thrombosis. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 41197806	2025
Platelet defects in patients and mice with Ehlers-Danlos syndrome. Blood\| PubMed ID: 41284637	2025
Evaluating tocilizumab in ischemic stroke: Findings from the SPAN multicenter trial. Neuropharmacology\| PubMed ID: 41354124	2025