awake-rat-model-ischemic-stroke-with-neuropsychiatric-complications

Awake Rat Model of Ischemic Stroke with Neuropsychiatric Complications During a Seven-Day Observation

The translational model of experimental stroke in rats induced by a gas embolism was created to clarify the features of stroke's development and to ...

Russian Federation

Russian Biotechnological University (BIOTECH University)

The TRPV1 channel is actively involved in various neuronal processes and is found in various structures of the nervous system, including peripheral and central neurons, sensory ganglia, spinal cord, and various parts of the brain. Due to its ability to respond to various stimuli, TRPV1 can have a significant impact on the body's responses to stress. Studies indicate the involvement of TRPV1 in the regulation of anxiety behavior. Suppression of TRPV1 activity leads to a decrease in the level of anxiety in animals, which indicates the importance of this channel in psychoemotional regulation. A promising compound for inhibiting this channel is the APHC3 peptide, which is a selective receptor antagonist. The results obtained this study show that this peptide has a pronounced anxiolytic effect, reducing the level of anxiety in the studied animals.

The Study of TRPV1 Channels of the Central Nervous System and Their Effect on Anxiety in ICR Mice.

Using the developed model of unpredictable mild chronic stress in rats, the time to the development of an anxious condition without severe depressive disorders were determined. A combination of stressors to achieve this condition is proposed: individual housing, food and water deprivation, forced swimming in cold (4°C) water, keeping on wet bedding and without bedding, under bright lighting, and at 45°C, light/dark cycle alterations, and 45° cage tilting. The condition of the animals was analyzed by changes in body weight, fructose consumption, coat state, as well as by the parameters of open field and forced swimming tests and nest building. These methods can be used in the study and search for new drugs for the treatment and prevention of anxiety- and depression-like conditions.

Article	Year
The Study of TRPV1 Channels of the Central Nervous System and Their Effect on Anxiety in ICR Mice. Doklady. Biochemistry and biophysics\| PubMed ID: 39023670	2024
Study of Behavioral Disorders in Laboratory Animals Using a Model of Unpredictable Chronic Mild Stress. Bulletin of experimental biology and medicine\| PubMed ID: 40445545	2025

Vladimir M. Pavlov

Biography

JoVE Journal Publications

Other Publications