Luca Digiacomo

NanoDelivery Lab, Sapienza University of Rome

Affiliated withSapienza University of Rome

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Personalized liposome-protein corona in the blood of breast, gastric and pancreatic cancer patients. The international journal of biochemistry & cell biology\| PubMed ID: 26369869	2016
Stealth effect of biomolecular corona on nanoparticle uptake by immune cells. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 26378619	2015
The protein corona of circulating PEGylated liposomes. Biochimica et biophysica acta\| PubMed ID: 26607013	2016
The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells. International journal of pharmaceutics\| PubMed ID: 26956159	2016
The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery. Scientific reports\| PubMed ID: 27165510	2016
Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles. Acta biomaterialia\| PubMed ID: 27449340	2016
Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 27565691	2017
Influence of dynamic flow environment on nanoparticle-protein corona: From protein patterns to uptake in cancer cells. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 28273493	2017
Impact of the biomolecular corona on the structure of PEGylated liposomes. Biomaterials science\| PubMed ID: 28676869	2017
Dynamic fingerprinting of sub-cellular nanostructures by image mean square displacement analysis. Scientific reports\| PubMed ID: 29093485	2017
Cationic lipid/DNA complexes manufactured by microfluidics and bulk self-assembly exhibit different transfection behavior. Biochemical and biophysical research communications\| PubMed ID: 29733845	2018
Brain Targeting by Liposome-Biomolecular Corona Boosts Anticancer Efficacy of Temozolomide in Glioblastoma Cells. ACS chemical neuroscience\| PubMed ID: 30015470	2018
Time-lapse confocal imaging datasets to assess structural and dynamic properties of subcellular nanostructures. Scientific data\| PubMed ID: 30226484	2018
Nanoparticle-biomolecular corona: A new approach for the early detection of non-small-cell lung cancer. Journal of cellular physiology\| PubMed ID: 30520022	2019
Protein Corona Fingerprints of Liposomes: New Opportunities for Targeted Drug Delivery and Early Detection in Pancreatic Cancer. Pharmaceutics\| PubMed ID: 30650541	2019
Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery. Nanoscale\| PubMed ID: 30672541	2019
Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells. Scientific reports\| PubMed ID: 30814595	2019
The biomolecular corona of gold nanoparticles in a controlled microfluidic environment. Lab on a chip\| PubMed ID: 31243412	2019
Interplay of protein corona and immune cells controls blood residency of liposomes. Nature communications\| PubMed ID: 31417080	2019
Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation. Allergy\| PubMed ID: 31713871	2020
A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 31857070	2020
Impact of the protein corona on nanomaterial immune response and targeting ability. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 32003104	2020
Author Correction: Interplay of protein corona and immune cells controls blood residency of liposomes. Nature communications\| PubMed ID: 32235830	2020
Personalized Graphene Oxide-Protein Corona in the Human Plasma of Pancreatic Cancer Patients. Frontiers in bioengineering and biotechnology\| PubMed ID: 32523944	2020
Effect of Glucose on Liposome-Plasma Protein Interactions: Relevance for the Physiological Response of Clinically Approved Liposomal Formulations. Advanced biosystems\| PubMed ID: 32627369	2019
A protein corona sensor array detects breast and prostate cancers. Nanoscale\| PubMed ID: 32776050	2020
Synergistic Analysis of Protein Corona and Haemoglobin Levels Detects Pancreatic Cancer. Cancers\| PubMed ID: 33396882	2020
Efficient pancreatic cancer detection through personalized protein corona of gold nanoparticles. Biointerphases\| PubMed ID: 33706529	2021
Inhibiting the Growth of 3D Brain Cancer Models with Bio-Coronated Liposomal Temozolomide. Pharmaceutics\| PubMed ID: 33809262	2021
The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine. Advanced drug delivery reviews\| PubMed ID: 33957181
The Possible Role of Sex As an Important Factor in Development and Administration of Lipid Nanomedicine-Based COVID-19 Vaccine. Molecular pharmaceutics\| PubMed ID: 33983745
Protein corona profile of graphene oxide allows detection of glioblastoma multiforme using a simple one-dimensional gel electrophoresis technique: a proof-of-concept study. Biomaterials science\| PubMed ID: 34018505	2021
Microfluidic Formulation of DNA-Loaded Multicomponent Lipid Nanoparticles for Gene Delivery. Pharmaceutics\| PubMed ID: 34452253	2021
Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles. Cancers\| PubMed ID: 34680304	2021
Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties . ACS nano\| PubMed ID: 35040637	2022
Magnetic Levitation of Personalized Nanoparticle-Protein Corona as an Effective Tool for Cancer Detection. Nanomaterials (Basel, Switzerland)\| PubMed ID: 35564106	2022
and nano-enabled immunomodulation by the protein corona. Nanoscale\| PubMed ID: 35833584	2022
Magnetic Levitation Patterns of Microfluidic-Generated Nanoparticle-Protein Complexes. Nanomaterials (Basel, Switzerland)\| PubMed ID: 35889600	2022
Efficient Delivery of DNA Using Lipid Nanoparticles. Pharmaceutics\| PubMed ID: 36015328	2022
Effect of molecular crowding on the biological identity of liposomes: an overlooked factor at the bio-nano interface. Nanoscale advances\| PubMed ID: 36132740	2019
Optimal centrifugal isolating of liposome-protein complexes from human plasma. Nanoscale advances\| PubMed ID: 36133013	2021
The protein corona reduces the anticancer effect of graphene oxide in HER-2-positive cancer cells. Nanoscale advances\| PubMed ID: 36133348	2022
Multiplexed Detection of Pancreatic Cancer by Combining a Nanoparticle-Enabled Blood Test and Plasma Levels of Acute-Phase Proteins. Cancers\| PubMed ID: 36230585	2022
Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study. ACS applied materials & interfaces\| PubMed ID: 36524967	2022
Stratifying Risk for Pancreatic Cancer by Multiplexed Blood Test. Cancers\| PubMed ID: 37296945	2023
Insights into the effect of polyethylene terephthalate (PET) microplastics on HER2 signaling pathways. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 37329963	2023
Investigating the mechanism of action of DNA-loaded PEGylated lipid nanoparticles. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 37507061	2023
Fast and portable fluorescence lifetime analysis for early warning detection of micro- and nanoplastics in water. Environmental research\| PubMed ID: 38109963	2024
Optimizing Transfection Efficiency in CAR-T Cell Manufacturing through Multiple Administrations of Lipid-Based Nanoparticles. ACS applied bio materials\| PubMed ID: 38775109	2024
Protein corona alleviates adverse biological effects of nanoplastics in breast cancer cells. Nanoscale\| PubMed ID: 39171675	2024
PEGylation-Dependent Cell Uptake of Lipid Nanoparticles Revealed by Spatiotemporal Correlation Spectroscopy. ACS pharmacology & translational science\| PubMed ID: 39421655	2024
Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery. Nature communications\| PubMed ID: 39438484	2024
Navigating the nano-bio immune interface: advancements and challenges in CNS nanotherapeutics. Frontiers in immunology\| PubMed ID: 39600701	2024
Nanoparticle-protein corona enhances accuracy of Ca-19.9-based pancreatic cancer classification. Nanoscale\| PubMed ID: 39868525	2025
Precondensed Plasmid DNA Enhances CAR‑T Cell Generation via Lipid Nanoparticles. ACS omega\| PubMed ID: 40686987	2025