Jason Miska

Department of Neurological Surgery, Northwestern University

Research Area

Biography

Jason Miska has not added Biography.
If you are Jason Miska and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205. Research square\| PubMed ID: 41041559	2025
Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models. Journal for immunotherapy of cancer\| PubMed ID: 41151835	2025
Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters. Journal of translational medicine\| PubMed ID: 27184224	2016
CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells. Cancer research\| PubMed ID: 27530322	2016
Anti-GITR therapy promotes immunity against malignant glioma in a murine model. Cancer immunology, immunotherapy : CII\| PubMed ID: 27734112	2016
A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model. Molecular therapy oncolytics\| PubMed ID: 28573184	2017
Fatty Acid Uptake in T Cell Subsets Using a Quantum Dot Fatty Acid Conjugate. Scientific reports\| PubMed ID: 28724939	2017
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 29503195	2018
Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene\| PubMed ID: 29991800	2018
A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 30027430	2018
Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model. Molecular neurobiology\| PubMed ID: 30460615	2019
Repolarization of myeloid derived suppressor cells via magnetic nanoparticles to promote radiotherapy for glioma treatment. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 30553919	2019
Activation of Dopamine Receptor 2 Prompts Transcriptomic and Metabolic Plasticity in Glioblastoma. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30651332	2019
Race influences survival in glioblastoma patients with KPS ≥ 80 and associates with genetic markers of retinoic acid metabolism. Journal of neuro-oncology\| PubMed ID: 30706176	2019
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma. Cell reports\| PubMed ID: 30943404	2019
FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene\| PubMed ID: 31324889	2019
Myeloid-Derived Suppressive Cells Promote B cell-Mediated Immunosuppression via Transfer of PD-L1 in Glioblastoma. Cancer immunology research\| PubMed ID: 31530559	2019
Current state of clinical trials in breast cancer brain metastases. Neuro-oncology practice\| PubMed ID: 31555454	2019
Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31712430	2019
GCN2 is essential for CD8 T cell survival and function in murine models of malignant glioma. Cancer immunology, immunotherapy : CII\| PubMed ID: 31844909	2020
OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity. The Journal of clinical investigation\| PubMed ID: 32182225	2020
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine. Science translational medicine\| PubMed ID: 32848091	2020
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma. The Journal of experimental medicine\| PubMed ID: 32991668	2021
Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem Cells. Cancers\| PubMed ID: 33114573	2020
Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma. Science advances\| PubMed ID: 33597238	2021
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma. Brain : a journal of neurology\| PubMed ID: 33855339	2021
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial. The Lancet. Oncology\| PubMed ID: 34214495	2021
Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34969858	2022
Checkpoint: Inspecting the barriers in glioblastoma immunotherapies. Seminars in cancer biology\| PubMed ID: 35150865	2022
Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity. Cells\| PubMed ID: 35269518	2022
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nature immunology\| PubMed ID: 35484407	2022
Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era. Frontiers in immunology\| PubMed ID: 35784281	2022
Next Steps for Immunotherapy in Glioblastoma. Cancers\| PubMed ID: 36011015	2022
Targeting fatty acid metabolism in glioblastoma. The Journal of clinical investigation\| PubMed ID: 36594473	2023
Endoplasmic Reticulum Stress in the Brain Tumor Immune Microenvironment. Molecular cancer research : MCR\| PubMed ID: 36652630	2023
B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression. Research square\| PubMed ID: 36711497	2023
IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM. Journal for immunotherapy of cancer\| PubMed ID: 36759014	2023
Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade. Nature communications\| PubMed ID: 36949040	2023
STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma. Nature communications\| PubMed ID: 36959214	2023
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Science advances\| PubMed ID: 37196077	2023
Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis. Neurosurgery\| PubMed ID: 37246885	2023
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis. Nature communications\| PubMed ID: 37452018	2023
Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases. The Journal of clinical investigation\| PubMed ID: 37847564	2023
LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression. Research square\| PubMed ID: 37886538	2023
GLUT3 regulates alternative macrophage signaling through a glucose transport-independent role. The Journal of clinical investigation\| PubMed ID: 37909335	2023
Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth. Cell metabolism\| PubMed ID: 38134929	2024
Modulation of macrophage metabolism as an emerging immunotherapy strategy for cancer. The Journal of clinical investigation\| PubMed ID: 38226622	2024
Antigen-presenting B cells promote TCF-1 PD1 stem-like CD8 T-cell proliferation in glioblastoma. Frontiers in immunology\| PubMed ID: 38268923	2023
The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context. Frontiers in immunology\| PubMed ID: 38299146	2023
Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas. The Journal of clinical investigation\| PubMed ID: 38357919	2024
Understanding the glioblastoma tumor microenvironment: leveraging the extracellular matrix to increase immunotherapy efficacy. Frontiers in immunology\| PubMed ID: 38380331	2024
CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. The Journal of clinical investigation\| PubMed ID: 38441967	2024
Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Nature communications\| PubMed ID: 38443336	2024
Prohibitin Expression in Antigen-Presenting Cells: Implications for Inciting Trigger in CNS IgG4-Related Disease. Annals of case reports\| PubMed ID: 38606301	2024
Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas. Nature communications\| PubMed ID: 38844770	2024
Editorial: Spatiotemporal heterogeneity in CNS tumors. Frontiers in immunology\| PubMed ID: 38868775	2024
Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas. Neuro-oncology\| PubMed ID: 39028616	2024
B cell-based therapy produces antibodies that inhibit glioblastoma growth. The Journal of clinical investigation\| PubMed ID: 39207859	2024
A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress. Scientific reports\| PubMed ID: 39304717	2024
IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas. Research square\| PubMed ID: 39711568	2024
It Is Not Just About Storing Energy: The Multifaceted Role of Creatine Metabolism on Cancer Biology and Immunology. International journal of molecular sciences\| PubMed ID: 39769038	2024
Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages. Science advances\| PubMed ID: 39841842	2025
Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma. iScience\| PubMed ID: 39949960	2025
Lipid peroxidation and immune activation: TRAF3's double-edged strategy against glioblastoma. The Journal of clinical investigation\| PubMed ID: 40166928	2025
Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity. Neuro-oncology\| PubMed ID: 40269603	2025
NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas. Research square\| PubMed ID: 40502769	2025
NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas. Journal of neuro-oncology\| PubMed ID: 40924320	2025
An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano-Immunotherapy. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 40944369	2025
cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 41183206	2025
Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds. Neuro-oncology\| PubMed ID: 41212520	2025
The role of regulatory T cells in central nervous system diseases in dogs: fighting with a double-edged sword toward translational discoveries. American journal of translational research\| PubMed ID: 41268269	2025