real-time-sampling-rat-femoral-arteriovenous-adventitial-interstitial

Real-Time Sampling of Rat Femoral Arteriovenous Adventitial Interstitial Fluid by Placement of a Microdialysis Probe

Interstitial fluid (ISF) is a vital element of the extracellular microenvironment, facilitating metabolic exchange and intercellular communication. ...

Chinese Academy of Medical Sciences

This pilot study aimed to prove the complementary value of a novel Gallium-labeled heterodimeric peptide, Ga-NOTA-3P-TATE-RGD, in detection and evaluation of tumors with somatostatin receptor subtype 2 or integrin αvβ3 overexpression, including non-small cell lung cancer (NSCLC), small-cell lung cancer (SCLC), neuroendocrine tumor (NET), and neuroendocrine carcinoma (NEC).

Evaluation of Lung Cancer and Neuroendocrine Neoplasm in a Single Scan by Targeting Both Somatostatin Receptor and Integrin αvβ3.

The aim of this prospective multi-center study was to investigate the diagnostic value of myocardial blood flow (MBF) quantification using NaI(Tl)-based single-photon emission computed tomography (SPECT) for determining coronary artery disease (CAD) defined by quantitative coronary angiography (QCA).

Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study.

Gastrointestinal stromal tumors (GISTs) are the most common stromal tumors in the gastrointestinal tract. This study was designed to evaluate a gastrin-releasing peptide receptor antagonist PET tracer, [Ga]Ga-NOTA-RM26, and compare it with [F]FDG PET/CT in the assessment of patients with GISTs.  With institutional review board approval and informed consent, 30 patients with suspected or proven GISTs based on abdominal CT or gastroscopy were recruited. All patients underwent [Ga]Ga-NOTA-RM26 and [F]FDG PET/CT scans. Pathology and other patient information were collected.  No radiopharmaceutical-related adverse events were observed in the patients. In total, 18 lesions in 16 patients were diagnosed as GIST, 3 patients were diagnosed with schwannoma, and 4 patients were diagnosed with leiomyoma. In 18 GISTs, the mean SUV of [Ga]Ga-NOTA-RM26 PET was significantly higher than that of [F]FDG PET (17.07 ± 19.57 vs. 2.28 ± 1.65;  < 0.01), and [Ga]Ga-NOTA-RM26 PET/CT had a higher tumor detection rate than did [F]FDG PET/CT (88.9% vs. 50%;  < 0.01). The uptake of [Ga]Ga-NOTA-RM26 in GISTs was significantly higher than that in 2 other benign tumors (leiomyoma or schwannoma) (17.07 ± 19.57 vs. 4.23 ± 1.77;  = 0.014). With the SUV cutoff value of 6.0, the sensitivity of Ga-NOTA-RM26 PET/CT in diagnosing GISTs is 72% and the specificity is 85.7%.  Compared with [F]FDG PET/CT, [Ga]Ga-NOTA-RM26 PET/CT is a promising and effective imaging modality for the detection of GISTs.

Head-to-Head Comparison of [Ga]Ga-NOTA-RM26 and [F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study.

A 39-year-old woman presented with left neck masses for 4 months and epiphora of the left eye for 3 weeks. Ultrasonography revealed a mass in the left parotid gland and multiple cervical lymph nodes. Biopsy of the mass in the left parotid gland revealed infiltrating ductal carcinoma. F-fluorodeoxyglucose positron emission tomography/computed tomography scan was undertaken, which showed a mass in the left parotid gland and multiple cervical lymph nodes with high metabolism. A nodule in the left nasolacrimal duct with high metabolism was observed. The nodule was surgically removed and pathologically confirmed as metastatic parotid ductal carcinoma.

Nasolacrimal Metastasis from Parotid Ductal Carcinoma Detected by F-FDG PET/CT.

This study was designed to evaluate 68 Ga-pentixafor, which targets C-X-C chemokine receptor 4 (CXCR4), in the noninvasive diagnosis of thymomas.

Clinical Application of 68 Ga-Pentixafor PET/CT for the Detection of Thymoma: A Pilot Study.

Secondary hyperparathyroidism (SHPT) is characterized by parathyroid hyperplasia, persistently elevated parathyroid hormone levels, and disturbances in mineral metabolism. Currently, a considerable amount of literature has consistently shown that thermal ablation is effective in maintaining parathyroid hormone levels within an appropriate range, normalizing calcium and phosphorus levels, improving clinical symptoms, and reducing the volume of parathyroid glands. However, there are currently no established guidelines regarding its utilization. The Asian consensus statement of experts on thermal ablation for SHPT in chronic kidney disease was jointly initiated by experts from China and Korea in the fields of nephrology, interventional ultrasound or radiology, thyroid surgery, ultrasound medicine, nuclear medicine, and diagnostic radiology-to formulate recommendations aimed at establishing standardized protocols for thermal ablation targeting the parathyroid glands. Based on the systematic review of literatures related to ultrasound-guided thermal ablation of parathyroid glands and the professional opinions of experts, the consensus statement covers the relevant content regarding thermal ablation treatment for SHPT, including indications, contraindications, pre-ablation evaluation, operational procedures, post-ablation follow-up, therapeutic effect evaluation, complications prevention and treatment. According to the Grading of Recommendations Assessment, Development and Evaluation, a total of 18 recommendations were given. This consensus statement will positively promote the standardization of ultrasound-guided thermal ablation of parathyroid glands.

Article	Year
Evaluation of Lung Cancer and Neuroendocrine Neoplasm in a Single Scan by Targeting Both Somatostatin Receptor and Integrin αvβ3. Clinical nuclear medicine\| PubMed ID: 31274560	2019
Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 35971031	2023
Head-to-Head Comparison of [Ga]Ga-NOTA-RM26 and [F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 39448271	2025
Nasolacrimal Metastasis from Parotid Ductal Carcinoma Detected by F-FDG PET/CT. Molecular imaging and radionuclide therapy\| PubMed ID: 39918104	2025
Clinical Application of 68 Ga-Pentixafor PET/CT for the Detection of Thymoma: A Pilot Study. Clinical nuclear medicine\| PubMed ID: 39988794	2025
Asian consensus statement of experts on thermal ablation for secondary hyperparathyroidism in chronic kidney disease. International journal of surgery (London, England)\| PubMed ID: 40391972	2025

YuMin Zheng

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