integrated-transcriptomic-secretome-proteomic-analysis-hyperglycemia

Integrated Transcriptomic and Secretome Proteomic Analysis of Hyperglycemia-Stimulated Endothelial Cells and Screening of Target Compounds

Endothelial dysfunction is a key driver of diabetic kidney disease (DKD), but its systemic molecular mechanisms remain incompletely decoded. We ...

Hebei Luoxue Innovation Medicine Research Institute

State Key Laboratory for Innovation and Transformation of Luobing Theory

Diabetic nephropathy (DN) drives progressive renal fibrosis and functional decline, ultimately leading to end-stage renal disease. Pathological crosstalk between glomerular endothelial cells and mesangial cells is increasingly recognized as central to DN progression. However, whether endothelial-derived signaling specifically drives mesangial injury under diabetic conditions remains undefined.

Min Shi

Biography

JoVE Journal Publications

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