integrated-transcriptomic-secretome-proteomic-analysis-hyperglycemia

Integrated Transcriptomic and Secretome Proteomic Analysis of Hyperglycemia-Stimulated Endothelial Cells and Screening of Target Compounds

Endothelial dysfunction is a key driver of diabetic kidney disease (DKD), but its systemic molecular mechanisms remain incompletely decoded. We ...

cardio-cerebral-protection-electroacupuncture-murine-model-chronic

Cardio-Cerebral Protection by Electroacupuncture in a Murine Model of Chronic Hypoxia

This study established a 12-week chronic hypoxia murine model to investigate the cardio-cerebral protective effects of electroacupuncture. Existing ...

a-combinatorial-mouse-model-circadian-disruption-dietary-stress-for

A Combinatorial Mouse Model of Circadian Disruption and Dietary Stress for Investigating Lifestyle-Accelerated Aging Pathophysiology

The goal of this protocol is to establish a standardized mouse model that recapitulates the multifactorial damage induced by modern, unhealthy lifestyles. ...

Hebei Medical University

Alzheimer's disease (AD) is the most common and severe degenerative disorder of the central nervous system in the elderly, profoundly impacting patients' quality of life. However, effective therapeutic agents for AD are still lacking. Bazi Bushen capsule (BZBS) is a traditional Chinese herbal compound with potential neuroprotective effects, yet its underlying mechanisms remain poorly understood.

Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice.

Photoaging is a prevalent and multifaceted form of exogenous skin aging. A comprehensive approach to preventing photoaging may yield greater benefits compared to a single intervention.

Bazi Bushen capsule alleviates skin photoaging by targeting the KEAP1-NRF2 pathway.

Diabetic nephropathy (DN) drives progressive renal fibrosis and functional decline, ultimately leading to end-stage renal disease. Pathological crosstalk between glomerular endothelial cells and mesangial cells is increasingly recognized as central to DN progression. However, whether endothelial-derived signaling specifically drives mesangial injury under diabetic conditions remains undefined.

ArticleTotal : 3	Year
Publication title	2025
Publication title	2026
Publication title	2026

Article	Year
Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice. Free radical biology & medicine\| PubMed ID: 40180019	2025
Bazi Bushen capsule alleviates skin photoaging by targeting the KEAP1-NRF2 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 41101077	2025
Verbascoside targets endothelial HIF-1α/ Lysyl oxidase signaling to attenuate glomerular injury in diabetic nephropathy. Redox report : communications in free radical research\| PubMed ID: 41355449	2025

Tianyu Kang

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