the-clinical-effect-combined-needle-embedding-therapy-for-patients

The Clinical Effect of Combined Needle-Embedding Therapy for Patients with Lifestyle-Related Dry Eye Disease

Dry eye disease (DED) is a multifactorial, chronic ocular surface disorder with a rising global prevalence. It has become an important public health ...

The First Affiliated Hospital of Chongqing Medical University

Biologics are increasingly used to treat Vogt-Koyanagi-Harada disease, but head-to-head comparisons with conventional immunosuppressants are lacking. Here in this randomized trial (Chinese Clinical Trial Registry, ChiCTR2100043061), we assigned 110 patients (27 early-phase and 83 late-phase) to cyclosporine-based immunosuppressant strategy (N = 56) or adalimumab-based biologic strategy (N = 54), each combined with a modified corticosteroid regimen. The primary outcome is change from baseline in best-corrected visual acuity at week 26. The margin of non-inferiority for cyclosporine is -7 letters. The primary outcome is 11.2 letters (95% CI, 7.5 to 14.9) in the cyclosporine group and 6.3 letters (95% CI, 3.1 to 9.6) in the adalimumab group (difference, 4.9; 95% CI, 0.2 to 9.5; P < 0.001 for non-inferiority). The between-group difference is -0.8 letters (95% CI, -6.1 to 4.5) in early-phase disease and 5.7 letters (95% CI, 0.2 to 11.2) in late-phase. Serious adverse events are reported less frequently in the cyclosporine group than in the adalimumab group (0.70 vs. 1.21 events per patient-year). Here, we report that combined with a non-standard corticosteroid regimen, cyclosporine-based immunosuppressant strategy is non-inferior to adalimumab-based biologic strategy by 26 weeks for visual improvement in a cohort of patients with Vogt-Koyanagi-Harada disease, 75% of whom have a late-phase disease.

A randomized non-inferiority trial of therapeutic strategy with immunosuppressants versus biologics for Vogt-Koyanagi-Harada disease.

To compare the 26-week cost-effectiveness of adalimumab-corticosteroids (ADA-CS) and cyclosporine-corticosteroids (CSA-CS) for Vogt-Koyanagi-Harada (VKH).

Cost-Effectiveness Analysis of Adalimumab Versus Cyclosporine for Vogt-Koyanagi-Harada Disease: A Randomized Controlled Study.

Data from head-to-head trials of immunomodulatory therapies for Behçet's disease are scarce. We aimed to compare the efficacy and safety of ciclosporin, interferon alfa-2a, and adalimumab, each combined with corticosteroids, in preventing uveitis relapse in patients with severe Behçet's disease.

Combinations of immunomodulatory agents for prevention of uveitis relapse in patients with severe Behçet's disease already on corticosteroid therapy: a randomised, open-label, head-to-head trial.

To evaluate the efficacy, timing of retreatment and safety of dexamethasone (DEX) implant on macular edema (ME) secondary to diabetic retinopathy (DME) and retinal vein occlusion (RVO-ME) patients who were refractory to anti-vascular endothelial growth factor (VEGF) treatment.

Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion.

To investigate the retinal microcirculation in mild preeclampsia (PE) without obvious retinopathy in high-altitude native Tibetans by optical coherence tomography angiography (OCTA).

Diminished retinal microcirculation in mild preeclampsia without obvious retinopathy in high-altitude native Tibetans by OCTA.

This study aimed to comprehensively explore the thickness and topographic distributions of retinal vessel alterations of different myopic eyes by using swept-source OCT angiography (SS-OCTA).

Compartmental analysis of retinal vascular parameters and thickness in myopic eyes using SS-OCTA.

So far, little is known about early macular microcirculation changes in nonfunctioning pituitary adenomas (NFPA), particularly in patients before visual field defects (VFD) occur. The aim of our study was to evaluate the early retinal microcirculation alteration in NFPA before VFD by wide-field swept source optical coherence tomography (WF SS-OCTA).

Early Retinal Microcirculation Loss in Nonfunctioning Pituitary Adenomas Before Visual Field Defect by Wide-Field Swept Source Optical Coherence Tomography.

The study aimed to compare interocular differences in choroidal thickness and circulation between the paired eyes of anisomyopic adults and to further investigate the potential connection between the choroid and myopia severity.

Interocular differences in choroidal thickness and circulation in anisomyopic adults and their association with myopia severity.

The dynamic changes of retinal microcirculation in Chinese Vogt-Koyanagi-Harada (VKH) patients have not yet been described. This study aimed to explore changes in retinal microcirculation among Chinese with VKH disease using optical coherence tomography angiography (OCTA) technology to determine whether patient outcomes improve due to therapeutic interventions.

Article	Year
A randomized non-inferiority trial of therapeutic strategy with immunosuppressants versus biologics for Vogt-Koyanagi-Harada disease. Nature communications\| PubMed ID: 37355662	2023
Cost-Effectiveness Analysis of Adalimumab Versus Cyclosporine for Vogt-Koyanagi-Harada Disease: A Randomized Controlled Study. Current eye research\| PubMed ID: 38783638	2024
Combinations of immunomodulatory agents for prevention of uveitis relapse in patients with severe Behçet's disease already on corticosteroid therapy: a randomised, open-label, head-to-head t... The Lancet. Rheumatology\| PubMed ID: 39236720	2024
Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion. International journal of ophthalmology\| PubMed ID: 39430031	2024
Diminished retinal microcirculation in mild preeclampsia without obvious retinopathy in high-altitude native Tibetans by OCTA. Photodiagnosis and photodynamic therapy\| PubMed ID: 39528006	2024
Compartmental analysis of retinal vascular parameters and thickness in myopic eyes using SS-OCTA. Frontiers in medicine\| PubMed ID: 39760034	2024
Early Retinal Microcirculation Loss in Nonfunctioning Pituitary Adenomas Before Visual Field Defect by Wide-Field Swept Source Optical Coherence Tomography. Neurosurgery\| PubMed ID: 40558060	2025
Interocular differences in choroidal thickness and circulation in anisomyopic adults and their association with myopia severity. Frontiers in medicine\| PubMed ID: 40761861	2025
Analysis of the Retinal Microcirculation in Chinese Patients With Vogt-Koyanagi-Harada Disease by Optical Coherence Tomography Angiography. Translational vision science & technology\| PubMed ID: 41247113	2025

Chong Tang

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