molecular-mechanisms-dbnl-heart-failure-from-macrophage

Molecular Mechanisms of DBNL in Heart Failure: From Macrophage Immunometabolism to Therapeutic Implications

Heart failure (HF) remains a major global health challenge, with limited effective treatments targeting its core pathophysiological mechanisms. In this ...

The First Affiliated Hospital of Ningbo University

Brugada syndrome (BrS) is a hereditary arrhythmia characterized by distinctive electrocardiographic patterns and a high risk of sudden cardiac death. Although SCN5A mutations account for 20%-30% of cases, the majority remain unexplained. Recent evidence suggests plasma proteins may contribute to BrS pathogenesis through non-ion channel mechanisms, such as inflammation and metabolism, although causal roles are unclear.

From blood to heartbeat: Plasma proteins and Brugada syndrome revealed by Mendelian randomization.

Doxorubicin-induced cardiomyopathy (DCM) remains a major clinical challenge, highlighting the need for early diagnostic biomarkers. Exosomal miRNAs are promising candidates due to their stability and regulatory functions in cardiovascular diseases.

Role of myocardium-derived exosomal miRNAs in doxorubicin-induced cardiomyopathy.

Coronary obstruction during transcatheter aortic valve replacement (TAVR) in bicuspid anatomy remains an unpredictable and potentially fatal complication. We report three representative bicuspid TAVR cases in which static computed tomography angiography (CTA) ratios-leaflet length relative to the sinotubular junction or coronary ostium-yielded conflicting or borderline risk signals. Intravascular ultrasound (IVUS) directly visualized dynamic coronary compromise and guided timely protective PCI. Each case highlights a distinct scenario: discordant metrics, borderline anatomy, and overt high-risk morphology. The combination of CTA and real-time IVUS provided decisive risk clarification and procedural safety. This case series underscores the limitations of static anatomic assessment and demonstrates the educational value of IVUS-guided decision-making in complex bicuspid TAVR.

Unveiling Hidden Threats: Intravascular Ultrasound-Guided Precise Intervention for Coronary Ostium Obstruction Risk in Bicuspid Transcatheter Aortic Valve Replacement.

Article	Year
From blood to heartbeat: Plasma proteins and Brugada syndrome revealed by Mendelian randomization. Heart rhythm\| PubMed ID: 41067469	2025
Role of myocardium-derived exosomal miRNAs in doxorubicin-induced cardiomyopathy. Gene\| PubMed ID: 41115580	2026
Unveiling Hidden Threats: Intravascular Ultrasound-Guided Precise Intervention for Coronary Ostium Obstruction Risk in Bicuspid Transcatheter Aortic Valve Replacement. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 41361842	2025

Binbin Cao

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