molecular-mechanisms-dbnl-heart-failure-from-macrophage

Molecular Mechanisms of DBNL in Heart Failure: From Macrophage Immunometabolism to Therapeutic Implications

Heart failure (HF) remains a major global health challenge, with limited effective treatments targeting its core pathophysiological mechanisms. In this ...

The First Affiliated Hospital of Ningbo University

Clopidogrel resistance profoundly increases the risk of major cardiovascular events in coronary artery disease (CAD) patients. Here, we comprehensively analyse global m6A modification alterations in clopidogrel-resistant (CR) and non-CR patients.

Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.

Clopidogrel resistance (CR) increases the risk of atherothrombotic events. Emerging evidence suggests that circRNAs may influence pharmacodynamic responses to clopidogrel.

Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.

Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged as significant regulators of gene expression, playing crucial roles in the occurrence and progression of various diseases. Research has shown that lncRNAs participate in the pathological process underlying CAVD by regulating osteogenic differentiation and inflammatory response of valve interstitial cells. Specifically, lncRNAs, such as H19, MALAT1, and TUG1, are closely associated with CAVD. Some lncRNAs can act as miRNA sponges, form complex regulatory networks, and modulate the expression of calcification-related genes. In brief, this review discusses the mechanisms and potential therapeutic targets of lncRNAs in CAVD.

Progress on long non-coding RNAs in calcific aortic valve disease.

Brugada syndrome (BrS) is a hereditary arrhythmia characterized by distinctive electrocardiographic patterns and a high risk of sudden cardiac death. Although SCN5A mutations account for 20%-30% of cases, the majority remain unexplained. Recent evidence suggests plasma proteins may contribute to BrS pathogenesis through non-ion channel mechanisms, such as inflammation and metabolism, although causal roles are unclear.

From blood to heartbeat: Plasma proteins and Brugada syndrome revealed by Mendelian randomization.

Doxorubicin-induced cardiomyopathy (DCM) remains a major clinical challenge, highlighting the need for early diagnostic biomarkers. Exosomal miRNAs are promising candidates due to their stability and regulatory functions in cardiovascular diseases.

Article	Year
Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance. Clinical epigenetics\| PubMed ID: 38098098	2023
Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA ... European journal of pharmacology\| PubMed ID: 39615866	2025
Progress on long non-coding RNAs in calcific aortic valve disease. Frontiers in cardiovascular medicine\| PubMed ID: 39898106	2025
From blood to heartbeat: Plasma proteins and Brugada syndrome revealed by Mendelian randomization. Heart rhythm\| PubMed ID: 41067469	2025
Role of myocardium-derived exosomal miRNAs in doxorubicin-induced cardiomyopathy. Gene\| PubMed ID: 41115580	2026

Jiahui Li

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