John C Gensel

Spinal Cord & Brain Injury Research Center, University of Kentucky

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PloS one\| PubMed ID: 23544088	2013
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia. Biological psychiatry\| PubMed ID: 24289885	2014
IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal co... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24966389	2014
Development of a database for translational spinal cord injury research. Journal of neurotrauma\| PubMed ID: 25077610	2014
Macrophage activation and its role in repair and pathology after spinal cord injury. Brain research\| PubMed ID: 25578260	2015
Large animal and primate models of spinal cord injury for the testing of novel therapies. Experimental neurology\| PubMed ID: 25902036	2015
Stress exacerbates neuron loss and microglia proliferation in a rat model of excitotoxic lower motor neuron injury. Brain, behavior, and immunity\| PubMed ID: 26100488	2015
Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26156997	2015
Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury. Experimental neurology\| PubMed ID: 26263843	2015
Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD\| PubMed ID: 26402096	2015
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. Nature communications\| PubMed ID: 26466022	2015
Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury. Journal of neuroinflammation\| PubMed ID: 26597676	2015
CNS Plasticity in Injury and Disease. Neural plasticity\| PubMed ID: 26881092	2016
Cardiac Chemical Exchange Saturation Transfer MR Imaging Tracking of Cell Survival or Rejection in Mouse Models of Cell Therapy. Radiology\| PubMed ID: 27420900	2017
Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury. Neurobiology of aging\| PubMed ID: 27596335	2016
Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. Scientific reports\| PubMed ID: 28057928	2017
Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery. Experimental neurology\| PubMed ID: 28365473	2017
Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury. Journal of neurotrauma\| PubMed ID: 28381129	2017
Macrophages are necessary for epimorphic regeneration in African spiny mice. eLife\| PubMed ID: 28508748	2017
Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury. Journal of neuroscience research\| PubMed ID: 28696010	2018
Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs. eNeuro\| PubMed ID: 28828403	2017
Interactions of primary insult biomechanics and secondary cascades in spinal cord injury: implications for therapy. Neural regeneration research\| PubMed ID: 29171424	2017
Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 29717413	2018
Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. PloS one\| PubMed ID: 30001416	2018
Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion. Journal of neuroinflammation\| PubMed ID: 30322390	2018
Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury. Brain, behavior, and immunity\| PubMed ID: 30453022	2019
Sexual Dimorphism of Pain Control: Analgesic Effects of Pioglitazone and Azithromycin in Chronic Spinal Cord Injury. Journal of neurotrauma\| PubMed ID: 30618345	2019
Macrolide derivatives reduce proinflammatory macrophage activation and macrophage-mediated neurotoxicity. CNS neuroscience & therapeutics\| PubMed ID: 30677254	2019
Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact. Experimental neurology\| PubMed ID: 31247195	2019
Therapeutic implications of advanced age at time of spinal cord injury. Neural regeneration research\| PubMed ID: 31290439	2019
Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury. Frontiers in cellular neuroscience\| PubMed ID: 31780896	2019
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice. Journal of neurosurgery. Pediatrics\| PubMed ID: 32032950	2020
Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. Experimental neurology\| PubMed ID: 32289316	2020
Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice. Journal of neurotrauma\| PubMed ID: 32597310	2020
Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury. Frontiers in neurology\| PubMed ID: 32849242	2020
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage. Journal of neurosurgery. Pediatrics\| PubMed ID: 32858507	2020
Continued development of azithromycin as a neuroprotective therapeutic for the treatment of spinal cord injury and other neurological conditions. Neural regeneration research\| PubMed ID: 32985477	2021
Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction. Scientific reports\| PubMed ID: 33024189	2020
Corrigendum: Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury. Frontiers in neurology\| PubMed ID: 33193066	2020
Mitochondria exert age-divergent effects on recovery from spinal cord injury. Experimental neurology\| PubMed ID: 33422552	2021
Reflections on Data Sharing Practices in Spinal Cord Injury Research. Neuroinformatics\| PubMed ID: 33454872	2022
Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 33460824	2021
Arginase 1 Insufficiency Precipitates Amyloid- Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis. Frontiers in immunology\| PubMed ID: 33519806	2020
Macrophage-Engineered Vesicles for Therapeutic Delivery and Bidirectional Reprogramming of Immune Cell Polarization. ACS omega\| PubMed ID: 33585763	2021
Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19. Frontiers in immunology\| PubMed ID: 33643308	2021
Author Correction: Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction. Scientific reports\| PubMed ID: 33731792	2021
The effects of myelin on macrophage activation are phenotypic specific via cPLA in the context of spinal cord injury inflammation. Scientific reports\| PubMed ID: 33737707	2021
Acute inflammatory profiles differ with sex and age after spinal cord injury. Journal of neuroinflammation\| PubMed ID: 33985529	2021
Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis. Frontiers in immunology\| PubMed ID: 34046031	2021
Promoting FAIR Data Through Community-driven Agile Design: the Open Data Commons for Spinal Cord Injury (odc-sci.org). Neuroinformatics\| PubMed ID: 34347243	2022
Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury. International journal of molecular sciences\| PubMed ID: 35008785	2021
Immunoglobulin G Is Increased in the Injured Spinal Cord in a Sex- and Age-Dependent Manner. Journal of neurotrauma\| PubMed ID: 35373588	2022
Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury. Journal of neurotrauma\| PubMed ID: 35373589	2022
Improving translatability of spinal cord injury research by including age as a demographic variable. Frontiers in cellular neuroscience\| PubMed ID: 36467608	2022
Data and subject heterogeneity and data sharing: keys to translational success in spinal cord injury research? Neural regeneration research\| PubMed ID: 36751797	2023
Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling. Neuron\| PubMed ID: 36863316	2023
PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injury. bioRxiv : the preprint server for biology\| PubMed ID: 37131840	2023
Effects of Acute Ethanol Intoxication on Spinal Cord Injury Outcomes in Female Mice. Journal of neurotrauma\| PubMed ID: 37350129	2023
PTEN knockout using retrogradely transported AAVs transiently restores locomotor abilities in both acute and chronic spinal cord injury. Experimental neurology\| PubMed ID: 37558155	2023
Azithromycin reduces hemoglobin-induced innate neuroimmune activation. Experimental neurology\| PubMed ID: 37852468	2024
Challenges in Translating Regenerative Therapies for Spinal Cord Injury. Topics in spinal cord injury rehabilitation\| PubMed ID: 38174141	2023
Tissue-resident macrophages specifically express Lactotransferrin and Vegfc during ear pinna regeneration in spiny mice. Developmental cell\| PubMed ID: 38228141	2024
Non-resolving neuroinflammation regulates axon regeneration in chronic spinal cord injury. bioRxiv : the preprint server for biology\| PubMed ID: 38712123	2024
A practical guide to data management and sharing for biomedical laboratory researchers. Experimental neurology\| PubMed ID: 38762093	2024
Cytosolic Phospholipase A2 in Infiltrating Monocyte-Derived Macrophages Does Not Impair Recovery After Spinal Cord Injury in Female Mice. Research square\| PubMed ID: 39483871	2024
Nonresolving Neuroinflammation Regulates Axon Regeneration in Chronic Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 39510834	2025
Data reporting quality and semantic interoperability increase with community-based data elements (CoDEs). Analysis of the open data commons for spinal cord injury (ODC-SCI). Experimental neurology\| PubMed ID: 39647573	2025
Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury. International journal of nanomedicine\| PubMed ID: 39691455	2024
Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice. Scientific reports\| PubMed ID: 39747330	2025
Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury. Journal of neuroinflammation\| PubMed ID: 39849507	2025
Redefining macrophage phenotypes after spinal cord injury: An open data approach. Experimental neurology\| PubMed ID: 40113007	2025
Complete High Thoracic Spinal Cord Injury Causes Bowel Dysfunction in Mice. Journal of neurotrauma\| PubMed ID: 40179002	2025
Sex-specific adaptive immune responses in spinal cord injury: Observations across species. Neural regeneration research\| PubMed ID: 40817728	2025
A Community Effort to Develop Common Data Elements for Pre-Clinical Spinal Cord Injury Research. Neurotrauma reports\| PubMed ID: 40918992	2025
Effects of sex, injury, and docosahexaenoic acid in a preclinical porcine model of pediatric traumatic brain injury using novel serial collection of CSF, urine, and serum biomarkers. Journal of neurosurgery. Pediatrics\| PubMed ID: 41004855	2025
Assessment of Cerebrospinal Fluid and Blood-Based Biomarkers in Degenerative Cervical Myelopathy: Systematic Review and Meta-Analysis. Global spine journal\| PubMed ID: 41097809	2025
Liposome-encapsulated clodronate and COX-2 inhibitor treatment impair ventilatory recovery but improve compensatory locomotor function following cervical spinal cord injury in rats. Experimental neurology\| PubMed ID: 41130383	2026