a-simple-rapid-method-for-simultaneous-isolation-primary-islets

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

In the research on the pathogenesis of post-acute pancreatitis diabetes mellitus (PPDM-A), abnormal bidirectional communication between pancreatic acinar ...

Naval Medical University

Nanodrug delivery systems (NDDS) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to several advantages, including functionalization capability, high drug-loading capacity, drug stability protection, and the enhanced permeability and retention (EPR) effect. However, their clinical translation still faces multiple challenges, including rapid clearance by the reticuloendothelial system (RES), poor targeting specificity, and insufficient efficiency in crossing biological barriers. To address these limitations, researchers have developed the biological carrier-mediated nanomedicine hitchhiking strategy (BCM-NHS), which leverages circulating cells, proteins, or bacteria as natural "mobile carriers" to enhance drug delivery. This approach enables nanocarriers to inherit the intrinsic biological properties, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, biodegradability, and naturally optimized biological interfaces. Here, a systematic overview of the BCM-NHS is provided. First, the review delves into the methods of nanoparticles (NPs) binding and immobilization, encompassing both the surface-attachment-mediated "backpack" strategy and the encapsulation-based "Trojan horse" strategy. Second, the classification of biological carriers, including both cell-based and non-cell-based carriers, is elucidated. Third, the physical properties and release mechanisms of these nanomaterials are thoroughly described. Finally, the latest applications of BCM-NHS in therapeutic and diagnostic contexts across various disease models including tumor, ischemic stroke, and pneumonia are highlighted.

Precision-Guided Stealth Missiles in Biomedicine: Biological Carrier-Mediated Nanomedicine Hitchhiking Strategy.

Nanodrug delivery systems (NDDSs) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to their nanoscale size advantages and high drug-loading capacity. However, their clinical translation still faces multiple challenges, including rapid clearance by the reticuloendothelial system (RES), nonspecific targeting, and insufficient efficiency in crossing biological barriers. Cell membrane-coated biomimetic delivery systems (CMC-BDS), which integrates natural cell membranes onto nanoparticle (NPs) surfaces, provides nanodrugs with a versatile "biomimetic cloak," representing a highly promising surface engineering strategy. This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. Furthermore, surface functionalization modifications can enhance their programmability, multifunctionality, and biointerface adaptability, thereby optimizing targeted delivery efficiency and extending in vivo circulation time. This review first outlines the development and key preparation steps of cell membrane coating technology. It then discusses the selection strategies for various cell membrane types-including leukocyte, erythrocyte, platelet, dendritic cell, tumor cell, and bacterial membranes-while comparing their respective advantages and limitations. Finally, the review highlights recent advances in applying cell membrane-coated nanoparticles (CMC-NPs) for treating tumors, ischemic stroke, and inflammatory diseases.

Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology.

Biological enzymes, with their high catalytic activity, strong specificity, and biocompatibility, hold significant application value in the biomedical field. However, their practical use is limited by high costs, poor environmental stability, and difficulties in large-scale production. In recent years, two-dimensional (2D) nanomaterials, with their high surface area, tunable enzyme-like catalytic activities (such as oxidase/peroxidase/catalase-mimicking properties), and unique photothermal/photodynamic effects, have provided new strategies for disease diagnosis and treatment. In this review, we first elucidate the bidirectional regulatory capacity of 2D nanozymes for redox reactions. We then classify and introduce the structural characteristics and catalytic mechanisms of various 2D nanozyme platforms, including carbon-based materials, black phosphorus, layered double hydroxides, transition metal oxides, metal-organic frameworks, MXenes, and other emerging nanomaterials. Finally, we summarize the latest research progress of 2D nanozymes in applications such as biosensors, cardiovascular diseases, bacterial infections, diabetic wounds, inflammatory bowel disease, arthritis, ischemic stroke, and cancer, highlighting their multifunctional theranostic effects. This review aims to provide theoretical references for the development of highly efficient and stable nanozyme materials and to promote the interdisciplinary development of catalytic medicine and nanotechnology.

Article	Year
Precision-Guided Stealth Missiles in Biomedicine: Biological Carrier-Mediated Nanomedicine Hitchhiking Strategy. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40345158	2025
Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology. Materials today. Bio\| PubMed ID: 40528836	2025
Precise modulation of redox reactions: A novel multifunctional theranostic platform based on 2D nanozymes. Materials today. Bio\| PubMed ID: 40969394	2025

Hanxiao Cui

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