Yanfen Chai

Tianjin Medical University General Hospital

Affiliated withTianjin Medical University General Hospital

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
[Advance in the study of the role of macrophages in the pathogenesis of sepsis]. Zhonghua wei zhong bing ji jiu yi xue\| PubMed ID: 23660103	2013
Macrophage polarization in inflammatory diseases. International journal of biological sciences\| PubMed ID: 24910531	2014
Effect of hemoperfusion cartridge on different internal environmental indicators. World journal of emergency medicine\| PubMed ID: 25215135	2013
Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma. Oncology letters\| PubMed ID: 25663933	2015
The role of regulatory T cells in immune dysfunction during sepsis. World journal of emergency medicine\| PubMed ID: 25802559	2015
Xuebijing Injection Promotes M2 Polarization of Macrophages and Improves Survival Rate in Septic Mice. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 26064161	2015
Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Scientific reports\| PubMed ID: 26577833	2015
Influence of Chest Compressions on Circulation during the Peri-Cardiac Arrest Period in Porcine Models. PloS one\| PubMed ID: 27168071	2016
Neuropilin-1highCD4⁺CD25⁺ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators of inflammation\| PubMed ID: 27239104	2016
Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+Regulatory T cells and improves survival rate in septic mice. Oncotarget\| PubMed ID: 27835904	2016
The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators of inflammation\| PubMed ID: 28210072	2017
[Chinese emergency medicine expert consensus on diagnosis and treatment of sepsis complicated with disseminated intravascular coagulation]. Zhonghua wei zhong bing ji jiu yi xue\| PubMed ID: 28743331	2017
The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled tria... BMC pulmonary medicine\| PubMed ID: 28931394	2017
Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments. Frontiers in immunology\| PubMed ID: 28970829	2017
Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction. International immunopharmacology\| PubMed ID: 29149705	2018
Sialic Acids in the Immune Response during Sepsis. Frontiers in immunology\| PubMed ID: 29209331	2017
Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock (Augusta, Ga.)\| PubMed ID: 29324628	2018
ADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial. Trials\| PubMed ID: 29467017	2018
Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis. Mediators of inflammation\| PubMed ID: 29706799	2018
Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis. International immunopharmacology\| PubMed ID: 30261464	2018
Identification of return of spontaneous circulation during cardiopulmonary resuscitation via pulse oximetry in a porcine animal cardiac arrest model. Journal of clinical monitoring and computing\| PubMed ID: 30498975	2019
Epithelial innate immunity mediates tubular cell senescence after kidney injury. JCI insight\| PubMed ID: 30674725	2019
Quick Sequential Organ Failure Assessment as a prognostic factor for infected patients outside the intensive care unit: a systematic review and meta-analysis. Internal and emergency medicine\| PubMed ID: 30725323	2019
Attenuation of Sepsis-Induced Cardiomyopathy by Regulation of MicroRNA-23b Is Mediated Through Targeting of MyD88-Mediated NF-κB Activation. Inflammation\| PubMed ID: 30734878	2019
XueBiJing Injection Versus Placebo for Critically Ill Patients With Severe Community-Acquired Pneumonia: A Randomized Controlled Trial. Critical care medicine\| PubMed ID: 31162191	2019
Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell death & disease\| PubMed ID: 31611560	2019
Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis. The American journal of pathology\| PubMed ID: 31676329	2020
Recombinant human ulinastatin improves immune dysfunction of dendritic cells in septic mice by inhibiting endoplasmic reticulum stress-related apoptosis. International immunopharmacology\| PubMed ID: 32473570	2020
Targeting Neuropilin-1 Suppresses the Stability of CD4 CD25 Regulatory T Cells via the NF-κB Signaling Pathway in Sepsis. Infection and immunity\| PubMed ID: 33139385	2021
Thyroid hormone disorders: a predictor of mortality in patients with septic shock defined by Sepsis-3? Internal and emergency medicine\| PubMed ID: 33151479	2021
A report on pneumonia-induced ventriculitis with intraventricular abscess. Chinese medical journal\| PubMed ID: 33177392	2020
[Effect of semaphorin-3A on the cellular stability of CD4CD25 regulatory T cells induced by lipopolysaccharide]. Zhonghua wei zhong bing ji jiu yi xue\| PubMed ID: 33541497	2020
[Complement 5a regulates the function of dendritic cells to induce pathogenic polarization of regulatory T cell/helper T cell 17 in sepsis]. Zhonghua wei zhong bing ji jiu yi xue\| PubMed ID: 33565394	2021
Immune checkpoints in sepsis: New hopes and challenges. International reviews of immunology\| PubMed ID: 33579182	2022
Semaphorin 3A contributes to sepsis‑induced immunosuppression by impairing CD4 T cell anergy. Molecular medicine reports\| PubMed ID: 33649856	2021
The effect of miR-21-5p on the MAP2K3 expressions and cellular apoptosis in the lung tissues of neonatal rats with hyperoxia-induced lung injuries. American journal of translational research\| PubMed ID: 34017441	2021
The roles of macrophage polarization in the host immune response to sepsis. International immunopharmacology\| PubMed ID: 34162154	2021
Predictors of acute kidney injury in patients with acute decompensated heart failure in emergency departments in China. The Journal of international medical research\| PubMed ID: 34510958	2021
Pulse oximetry waveform: A non-invasive physiological predictor for the return of spontaneous circulation in cardiac arrest patients ---- A multicenter, prospective observational study. Resuscitation\| PubMed ID: 34624410	2021
Diagnostic value and significance of serum miR-132 combined with miR-223 for sepsis-induced cardiomyopathy. Experimental and therapeutic medicine\| PubMed ID: 34650644	2021
The contribution of neuropilin-1 in the stability of CD4 CD25 regulatory T cells through the TGF-β1/Smads signaling pathway in the presence of lipopolysaccharides. Immunity, inflammation and disease\| PubMed ID: 34758202	2022
Remote ischemic postconditioning protects against crush-induced acute kidney injury via down-regulation of apoptosis and senescence. European journal of trauma and emergency surgery : official publication of the European Trauma Society\| PubMed ID: 35224648	2022
Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? Frontiers in immunology\| PubMed ID: 35281010	2022
Cellular senescence and acute kidney injury. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 35338388	2022
Insight Into Regulatory T Cells in Sepsis-Associated Encephalopathy. Frontiers in neurology\| PubMed ID: 35370925	2022
Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy. Frontiers in physiology\| PubMed ID: 35492613	2022
Ulinastatin Alleviates Rhabdomyolysis-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis via Inhibiting TLR4/NF-κB Signaling Pathway. Inflammation\| PubMed ID: 35668155	2022
S100A9 and SOCS3 as diagnostic biomarkers of acute myocardial infarction and their association with immune infiltration. Genes & genetic systems\| PubMed ID: 35675985	2022
Dynamic changes of emergency visits: a retrospective observational study. BMC emergency medicine\| PubMed ID: 35690727	2022
Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis. BMC infectious diseases\| PubMed ID: 35729526	2022
Use of Quantitative Metagenomics Next-Generation Sequencing to Confirm Fever of Unknown Origin and Infectious Disease. Frontiers in microbiology\| PubMed ID: 35859749	2022
The Role of Histone H3 Methylation in Acute Kidney Injury. Drug design, development and therapy\| PubMed ID: 35941926	2022
Diagnostic Value of Metagenomic Next-Generation Sequencing for Pulmonary Infection in Intensive Care Unit and Non-Intensive Care Unit Patients. Frontiers in cellular and infection microbiology\| PubMed ID: 36046746	2022
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling. Pharmacological research\| PubMed ID: 36182039	2022
Blue rubber bleb nevus syndrome complicated with disseminated intravascular coagulation and intestinal obstruction: A case report. World journal of clinical cases\| PubMed ID: 36405278	2022
Omega-3 polyunsaturated fatty acids inhibit cardiomyocyte apoptosis and attenuate sepsis-induced cardiomyopathy. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 36459842	2023
Angiotensin-(1-7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways. Journal of translational medicine\| PubMed ID: 36593471	2023
RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation. Immunopharmacology and immunotoxicology\| PubMed ID: 36650938	2023
Unexplained hyperammonemia and encephalopathy in the emergency department: Abernethy malformation in elderly patients. World journal of emergency medicine\| PubMed ID: 36713341	2023
Analysis of factors influencing cardiopulmonary resuscitation and survival outcome in adults after in-hospital cardiac arrest: a retrospective observational study. Chinese medical journal\| PubMed ID: 36728511	2022
Clinical practice of emergency department-initiated extracorporeal cardiopulmonary resuscitation for cardiac arrest in adults. Chinese medical journal\| PubMed ID: 36806089	2023
A 30-Year-Old Woman with a History of Autoimmune Hyperthyroidism Presenting with Fever and Oral Ulcers, Diagnosed with Discoid Lupus Erythematosus. The American journal of case reports\| PubMed ID: 37038339	2023
A novel role of DOT1L in kidney diseases. Molecular biology reports\| PubMed ID: 37085741	2023
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial. JAMA internal medicine\| PubMed ID: 37126332	2023
Severe Hypokalemia Complicated by Acute Myopathy: Initial Manifestation of Primary Sjögren's Syndrome-Associated Renal Tubular Acidosis. The American journal of case reports\| PubMed ID: 37481699	2023
Circ_0040994 depletion alleviates lipopolysaccharide-induced HK2 cell injury through miR-17-5p/TRPM7 axis. Environmental toxicology\| PubMed ID: 37483096	2023
Factors affecting do-not-attempt-resuscitation (DNAR) decisions among adult patients in the emergency department of a general tertiary teaching hospital in China: a retrospective observation... BMJ open\| PubMed ID: 37816558	2023
The roles of tissue-resident macrophages in sepsis-associated organ dysfunction. Heliyon\| PubMed ID: 38027963	2023
A national survey on current state and development needs of clinical and academic emergency medicine in China. BMC medical education\| PubMed ID: 38439054	2024
Correction: A national survey on current state and development needs of clinical and academic emergency medicine in China. BMC medical education\| PubMed ID: 38632574	2024
H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway. Renal failure\| PubMed ID: 38856314	2024
Colchicine poisoning: Case report of three homicides in a family. Heliyon\| PubMed ID: 38947441	2024
The impact of diabetes on Sepsis-induced cardiomyopathy. Diabetes research and clinical practice\| PubMed ID: 39826649	2025
Integrated Omics Insights into Dapagliflozin Effects in Sepsis-Induced Cardiomyopathy. Biomolecules\| PubMed ID: 40001588	2025
Pharmacobezoars: the challenges of gastric lavage for a patient with drug overdose. World journal of emergency medicine\| PubMed ID: 40135210	2025
Establishing a prediction model for lower extremity deep venous thrombosis in emergency inpatients in the post epidemic era. Frontiers in surgery\| PubMed ID: 40260179	2025
Risk factors for death in patients with acute diquat poisoning. World journal of emergency medicine\| PubMed ID: 40406292	2025
Interaction between gut-heart axis in sepsis-induced cardiomyopathy. Pharmacological research\| PubMed ID: 40449812	2025
Prediction model of in-hospital mortality risk in intensive care unit patients with cardiac arrest: a multicenter retrospective cohort study based on an ensemble model. Frontiers in cardiovascular medicine\| PubMed ID: 40463634	2025
Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome. Antioxidants (Basel, Switzerland)\| PubMed ID: 40563352	2025
Association of serum creatinine-to-albumin ratio with 28-day all-cause mortality in older adults critically ill patients with sepsis: a retrospective analysis of the MIMIC-IV database. BMC geriatrics\| PubMed ID: 40604550	2025
Life-threatening gastrointestinal bleeding in a rare case of blue rubber bleb nevus syndrome. World journal of emergency medicine\| PubMed ID: 40708742	2025
Aortic dissection induced by licorice tablets overdose: a Case Report. Frontiers in pharmacology\| PubMed ID: 40949145	2025
Efficacy and Safety of a Generic Clevidipine in Hypertensive Urgencies and Non-Fulminant Hypertensive Emergencies: A Phase III, Multicenter, Randomized, Double-Blind, Positive Drug Parallel-... Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 41085098	2025
Predictive value of PD-1CD3 T cells for 30-day mortality in patients with sepsis. Scientific reports\| PubMed ID: 41120398	2025
Timing of Treatment and Long-Term Outcomes in Poor-Grade Aneurysmal Subarachnoid Hemorrhage: A Multicenter Analysis. Neurocritical care\| PubMed ID: 41168612	2025
Efficacy and safety of clevidipine emulsion injection compared with nicardipine in patients with hypertensive emergencies: a randomized, single-blind, positive-parallel-controlled, phase III... Journal of hypertension\| PubMed ID: 41231022	2026
Comparison of Efficacy and Safety Profiles Between Omadacycline and Moxifloxacin in Elderly Patients with Community-Acquired Pneumonia: A Randomized, Controlled Trial. Clinical pharmacology in drug development\| PubMed ID: 41267642	2025