optical-mapping-atrial-electrophysiological-calcium-handling

Optical Mapping of Atrial Electrophysiological and Calcium Handling Abnormalities in a Rat Model of Sterile Pericarditis

Postoperative atrial fibrillation (POAF) frequently arises after cardiac surgery and is associated with atrial inflammation and remodeling. The sterile ...

Xuzhou Central Hospital

The incidence of ischemic cardiomyopathy increases annually worldwide, and it is the leading cause of mortality in China. Although interventional diagnostic and therapeutic techniques can promptly open the culprit vessels, myocardial ischemia-reperfusion injury (MIRI), resulting from restored blood flow, is often inevitable. Semaglutide (Sem), a novel GLP-1 analogue, is primarily utilized in managing Type 2 diabetes mellitus (T2DM). Recent research indicates that semaglutide may reduce the risk of major adverse cardiovascular events. Therefore, the purpose of this study is to explore whether semaglutide can ameliorate MIRI and explore its potential mechanism.

Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.

Activation of transient receptor potential vanilloid 4 (TRPV4) exacerbates myocardial ischemia-reperfusion (IR) injury and is highly expressed in vascular endothelial cells. The role of TRPV4 in cardiac endothelial cells (CECs) during IR remains unclear. We hypothesized that endothelial TRPV4 contributes to postischemic vascular hyperpermeability and myocardial injury by modulating barrier function and apoptosis.

Article	Year
Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis. Frontiers in pharmacology\| PubMed ID: 40183087	2025
Activation of Endothelial TRPV4 Exacerbates Myocardial Ischemia-Reperfusion Injury via Vascular Integrity Impairment. The Canadian journal of cardiology\| PubMed ID: 41238115	2025

Yingyu Chen

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