ct-guided-preoperative-localization-pulmonary-nodules-using-glucose

CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive

Intraoperative localization of ground-glass nodules (GGNs) is challenging. This study evaluates a CT-guided protocol that innovatively combines a glucose ...

Fudan University

Shanghai Institute of Medical Imaging

Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) is a critical coenzyme for glucose metabolism and significantly reduced in brain and blood samples of patients with Alzheimer's disease (AD).

Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis.

Tumor-Infiltrating Lymphocytes (TILs) immunotherapy is a highly promising treatment for Non-small Cell Lung Cancer (NSCLC), which is responsible for 18% of all cancer-related deaths. The heterogeneity of TILs remains poorly understood. Here, we utilized combined single-cell RNA (scRNA)/T cell receptor sequencing (scTCR-seq) data from lung adenocarcinoma (LUAD) patients. Naïve CD4 and effector memory CD8 T cells were increased in tumor tissue compared with circulating blood samples. Activated signaling pathways were detected, and GZMA was identified as a potential novel diagnostic biomarker. During the transitional phase, macrophages (FTL) and dendritic (AIF1) cells transported the most CD3 TCR clones to T cells, while cytotoxicity CD8 T (NKG7) cells transported to terminal exhausted CD8 T cells. In both transition and expansion phases, T helper cells (CXCL13) are transported to regulatory T cells (Tregs). Additionally, we investigated the expression profiles of key cytokines, checkpoint receptors, and their ligands. Cytotoxicity CD8 T cells (CCL5 and IFNG), T helper cells (FTL, TNFRSF4, and TIGIT), and regulatory T cells (CTLA4, TIGIT and FTL) exhibited functional roles in both primary and metastatic tumor stages. Taken together, our study provides a single-cell resolution of the TIL immune landscape and suggests potential treatment strategies to overcome drug resistance.

Article	Year
Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis. EBioMedicine\| PubMed ID: 26870826	2016
Characterizing the immune landscape of tumor-infiltrating lymphocytes in non-small cell lung cancer. Genes and immunity\| PubMed ID: 40325180	2025

Xiaohua Gu

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