Louise C Serpell

School of Life Sciences, University of Sussex

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Structure and morphology of the Alzheimer's amyloid fibril. Microscopy research and technique\| PubMed ID: 16103997	2005
Structures for amyloid fibrils. The FEBS journal\| PubMed ID: 16302960	2005
Diffraction to study protein and peptide assemblies. Current opinion in chemical biology\| PubMed ID: 16931111	2006
Structural analyses of fibrinogen amyloid fibrils. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 17701467	2007
Amyloid fibrils: abnormal protein assembly. Prion\| PubMed ID: 19158505	2008
Structural integrity of beta-sheet assembly. Biochemical Society transactions\| PubMed ID: 19614573	2009
Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch. Biophysical journal\| PubMed ID: 20338855	2010
The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20923185	2010
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability. Biochemistry\| PubMed ID: 21288003	2011
Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes. The Biochemical journal\| PubMed ID: 21702743	2011
Membrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity. The FEBS journal\| PubMed ID: 21722314	2011
Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. The Biochemical journal\| PubMed ID: 21955321	2012
X-ray fibre diffraction studies of amyloid fibrils. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22528087	2012
Exploring the sequence-structure relationship for amyloid peptides. The Biochemical journal\| PubMed ID: 23252554	2013
The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1. Angewandte Chemie (International ed. in English)\| PubMed ID: 23307646	2013
Chemically programmed self-sorting of gelator networks. Nature communications\| PubMed ID: 23403581	2013
A central role for dityrosine crosslinking of Amyloid-β in Alzheimer's disease. Acta neuropathologica communications\| PubMed ID: 24351276	2013
The relationship between amyloid structure and cytotoxicity. Prion\| PubMed ID: 24819071	2014
Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron\| PubMed ID: 24857020	2014
Computational de novo design of a self-assembling peptide with predefined structure. Journal of molecular biology\| PubMed ID: 25498388	2015
Structural determinants in a library of low molecular weight gelators. Soft matter\| PubMed ID: 25562785	2015
The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 25849399	2015
Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network. Scientific reports\| PubMed ID: 26024049	2015
Modular Design of Self-Assembling Peptide-Based Nanotubes. Journal of the American Chemical Society\| PubMed ID: 26219086	2015
Silica Nanowires Templated by Amyloid-like Fibrils. Angewandte Chemie (International ed. in English)\| PubMed ID: 26434656	2015
Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation. FEBS letters\| PubMed ID: 26450778	2015
Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP). Biochimica et biophysica acta\| PubMed ID: 26699836	2016
Nuclear Tau and Its Potential Role in Alzheimer's Disease. Biomolecules\| PubMed ID: 26751496	2016
A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration. Scientific reports\| PubMed ID: 27443509	2016
Silica Nanowires Templated by Amyloid-like Fibrils. Angewandte Chemie (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 27478270	2015
Chemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnology. Journal of nanobiotechnology\| PubMed ID: 27905946	2016
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease. Scientific reports\| PubMed ID: 27982082	2016
Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42. FEBS letters\| PubMed ID: 28185264	2017
Controlling the network type in self-assembled dipeptide hydrogels. Soft matter\| PubMed ID: 28186211	2017
Structure-dependent effects of amyloid-β on long-term memory in Lymnaea stagnalis. FEBS letters\| PubMed ID: 28337747	2017
Cathepsin K as a novel amyloid fibril protein in humans. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28485639	2017
Kinetically Controlled Coassembly of Multichromophoric Peptide Hydrogelators and the Impacts on Energy Transport. Journal of the American Chemical Society\| PubMed ID: 28578581	2017
Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors. Biomaterials\| PubMed ID: 28622603	2017
The amyloid architecture provides a scaffold for enzyme-like catalysts. Nanoscale\| PubMed ID: 28722055	2017
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. Journal of molecular biology\| PubMed ID: 28919235	2017
The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides. Interface focus\| PubMed ID: 29147557	2017
Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA. Molecular microbiology\| PubMed ID: 29802781	2018
The involvement of tau in nucleolar transcription and the stress response. Acta neuropathologica communications\| PubMed ID: 30064522	2018
Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT). Journal of molecular biology\| PubMed ID: 30121297	2018
The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction. Frontiers in cellular neuroscience\| PubMed ID: 30123109	2018
Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution. ACS nano\| PubMed ID: 30157375	2018
Methods for Structural Analysis of Amyloid Fibrils in Misfolding Diseases. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30341606	2019
A Biophysical Approach to the Identification of Novel ApoE Chemical Probes. Biomolecules\| PubMed ID: 30700058	2019
The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease. Journal of molecular biology\| PubMed ID: 31051176	2019
Zinc-dysprosium functionalized amyloid fibrils. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 31107476	2019
Using chirality to influence supramolecular gelation. Chemical science\| PubMed ID: 31588329	2019
Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain. FEBS letters\| PubMed ID: 31721178	2020
Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway. Cellular and molecular life sciences : CMLS\| PubMed ID: 32025743	2020
Transition of Nano-Architectures Through Self-Assembly of Lipidated β-Tripeptide Foldamers. Frontiers in chemistry\| PubMed ID: 32296680	2020
Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs. Biomolecular concepts\| PubMed ID: 32374275	2020
Paired Helical Filament-Forming Region of Tau (297-391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells. Journal of molecular biology\| PubMed ID: 32681841	2020
Internalisation and toxicity of amyloid-β 1-42 are influenced by its conformation and assembly state rather than size. FEBS letters\| PubMed ID: 32871611	2020
Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity. iScience\| PubMed ID: 33083713	2020
Nucleation-dependent Aggregation Kinetics of Yeast Sup35 Fragment GNNQQNY. Journal of molecular biology\| PubMed ID: 33279578	2021
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target. Frontiers in neurology\| PubMed ID: 33281730	2020
MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments. Frontiers in molecular neuroscience\| PubMed ID: 33328883	2020
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates. Cells\| PubMed ID: 33809978	2021
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β. Scientific reports\| PubMed ID: 34078941	2021
AlphaFold: A Special Issue and A Special Time for Protein Science. Journal of molecular biology\| PubMed ID: 34508726	2021
Salpyran: A Cu(II) Selective Chelator with Therapeutic Potential. Inorganic chemistry\| PubMed ID: 34609139	2021
The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau. Frontiers in molecular biosciences\| PubMed ID: 34778381	2021
Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis. Journal of molecular biology\| PubMed ID: 35077765	2022
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro. Journal of molecular biology\| PubMed ID: 35961386	2022
Charge screening wormlike micelles affects extensional relaxation time and noodle formation. Chemical communications (Cambridge, England)\| PubMed ID: 36039700	2022
An Additive-Free Model for Tau Self-Assembly. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36310203	2023
Shapeshifting tau: from intrinsically disordered to paired-helical filaments. Essays in biochemistry\| PubMed ID: 36373666	2022
Transferring Micellar Changes to Bulk Properties via Tunable Self-Assembly and Hierarchical Ordering. ACS nano\| PubMed ID: 36441928	2022
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391). Frontiers in neuroscience\| PubMed ID: 36570831	2022
Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly. Communications chemistry\| PubMed ID: 36703355	2020
Chiral CoY Propeller-Shaped Chemosensory Platforms Based on F-NMR. Inorganic chemistry\| PubMed ID: 36716401	2023
Dityrosine cross-linking and its potential roles in Alzheimer's disease. Frontiers in neuroscience\| PubMed ID: 37034163	2023
Corrigendum: The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau. Frontiers in molecular biosciences\| PubMed ID: 37790876	2023
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons. Structure (London, England : 1993)\| PubMed ID: 38471506	2024
Atomic Scale Structure of Self-Assembled Lipidated Peptide Nanomaterials. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 38489817	2024
Maturation and Conformational Switching of a Designed Phase-Separating Polypeptide. Journal of the American Chemical Society\| PubMed ID: 38578222	2024
Molecular organization of fibroin heavy chain and mechanism of fibre formation in Bombyx mori. Communications biology\| PubMed ID: 38951579	2024
Tau-mediated synaptic dysfunction is coupled with HCN channelopathy. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 38994745	2024
Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant. Stem cell research\| PubMed ID: 39067409	2024
Expanding the Protein Universe. Journal of molecular biology\| PubMed ID: 39368699	2024
Somatic and Stem Cell Bank to Study the Contribution of African Ancestry to Dementia: African iPSC Initiative. medRxiv : the preprint server for health sciences\| PubMed ID: 39974113	2025
Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 40219788	2025
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine. Journal of molecular biology\| PubMed ID: 40441413	2025
Self-Assembly of Off-Target Peptide Sequences: Implications for the Design of Soft Materials. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 40898678	2025
Mutant MAPT Induces rDNA Transcriptional Hyperactivation and Nucleolar Stress in Cellular Models. Research square\| PubMed ID: 41255983	2025
Structural reconstruction of individual filaments in Aβ fibril populations assembled in vitro reveal rare species that resemble ex vivo amyloid polymorphs from human brains. Communications chemistry\| PubMed ID: 41261167	2025
Inhibiting Disulfide Bonding in Truncated Tau297-391 Results in Enhanced Self-Assembly of Tau into Seed-Competent Assemblies. ACS chemical neuroscience\| PubMed ID: 41373058	2026
Mechanism of Self-Assembly of the Gonadropin Releasing Hormone Antagonist Teverelix into Amyloid Fibrils. Molecular pharmaceutics\| PubMed ID: 41411501	2026