development-mesenchymal-stem-cell-membrane-enveloped-nanovesicles-for

Development of Mesenchymal Stem Cell Membrane-Enveloped Nanovesicles for Enhanced Gene Delivery

Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) hold great promise for therapeutic applications and regenerative medicine. EVs are ...

Guangdong Institute of Intelligence Science and Technology

Employing appropriate single-atom (SA) catalysts in room-temperature sodium-sulfur (Na-S) batteries is propitious to promote the performance, whereas a universal designing strategy for the highly-efficient single-atom catalysts is absent. In this work, we adopt natural language processing techniques to screen the potential single-atom catalysts, then a binary descriptor is constructed to optimize the catalyst candidates. Atomically dispersed cobalt anchored to both nitrogen and sulfur atoms (SA Co-N/S) is selected as an ideal catalyst to significantly facilitate sulfur reduction reaction. The sulfur cathode catalyzed with SA Co-N/S almost realizes complete transformation, and the corresponding pouch cell exhibits satisfactory performance with high mass loading. In-situ X-ray absorption spectroscopy reveals the dynamical interactions between SA Co-N/S and sulfur species in the sulfur reduction reaction. Our work provides a method to select the preferable SA catalyst and to understand the interfacial catalysis dynamics in the sustainable Na-S systems.

Preferable single-atom catalysts enabled by natural language processing for high energy density Na-S batteries.

Vascular dysfunction causes vascular pain (VP), the most common clinical manifestation of prevalent vascular diseases, while the mechanisms remain elusive. Mouse models are developed by mimicking peripheral vascular diseases and combining multiple strategies to demonstrate that primary sensory neuronal endothelin A receptor (ETAR) mediates experimental and clinical VP through an endothelial-neural axis. Endothelial cells (ECs), but not macrophages or smooth muscle cells (SMCs), release endothelin-1 (ET-1) and directly activate primary sensory neurons by binding to ETAR on sensory neurons, resulting in VP. Mice that underwent vessel ligation exhibit long-lasting mechanical hyperalgesia, but no heat hyperalgesia or cold allodynia, without inflammatory cell infiltration into or gliosis in the nervous system. These mice also display a moderate decrease in blood perfusion in the affected hindpaws, without evident ischemic injury or tissue necrosis after vessel ligation. Activating ECs with optogenetics or chemogenetics elicits spontaneous pain-like behaviors and lasting mechanical hyperalgesia. Blocking the increased endothelial ET-1/neural ETAR signal reduces pain-like behaviors caused by vessel ligation or activation of ECs. Treatment with oral bosentan alleviates VP in clinical patients with tourniquet-induced VP. These findings suggest that targeting the endothelial-neural axis and ET-1/ETAR pathway may represent therapeutic strategies for VP.

Article	Year
Preferable single-atom catalysts enabled by natural language processing for high energy density Na-S batteries. Nature communications\| PubMed ID: 40593622	2025
Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial-Neural Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40810652	2025

Di Mu

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