exosomal-linc01614-from-gastric-cancer-cells-drives-treg

Exosomal LINC01614 from Gastric Cancer Cells Drives Treg Differentiation

This study aimed to investigate the potential mechanism by which LINC01614, a long non-coding RNA (lncRNA), regulates the immune microenvironment of ...

The Second Affiliated Hospital of Zunyi Medical University

 To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery.  A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascularization of the newly born tissue compound were analyzed and evaluated by tissue staining and Micro-CT scanning.  The neoplastic fibrous tissue formed in the vascularized tissue engineering chamber with the introduction of abdominal superficial vessels, similar to normal fascia, was superior to the control group in terms of vascularization, vascular density, total vascular volume, and total vascular volume/total tissue volume.  , introducing abdominal superficial vessels in the tissue engineering chamber prepped for ear prosthesis may form a well-vascularized pedicled fascia-prosthesis compound that can be used for ear reconstruction.

Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery.

Nonylphenol (NP) is a common environmental contaminant and endocrine disruptor. Our previous research demonstrated that NP could promote the proliferation and epithelial-mesenchymal transition (EMT) of colorectal cancer (CRC) cells; however, the specific mechanism remains unclear. miRNA sequencing revealed that NP upregulated the expression levels of microRNA(miR)-151a-3p in CRC. Analysis of The Cancer Genome Atlas (TCGA) data revealed increased expression levels of miR-151a-3p in CRC tissues. The present experiments showed that NP could activate the WNT/β-catenin signaling pathway, and promoted the migration and invasion of CRC cells by increasing the expression levels of miR-151a-3p. Through bioinformatics analysis and dual-luciferase reporter assays, Fyn-related kinase (FRK) was identified as a target gene of miR-151a-3p. Knockdown of FRK promoted NP-induced EMT in CRC cells and activated the WNT/β-catenin signaling pathway, while overexpression had the opposite effect. In summary, the present study demonstrated that NP could inhibit FRK expression via miR-151a-3p, activate the WNT/β-catenin signaling pathway, and promote EMT in CRC cells.

Article	Year
Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery. Frontiers in bioengineering and biotechnology\| PubMed ID: 37292096	2023
Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p. Discover oncology\| PubMed ID: 39832042	2025

Biao Wang

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