breast-cancer-combined-with-primary-lung-cancer-study

Breast Cancer Combined with Primary Lung Cancer: A Study of Clinicopathologic Features and Prognostic Factors

We conducted a single-center retrospective study of patients with breast cancer (BC) who developed a second primary lung cancer (pLC) (BC-pLC; n = 54) ...

Weifang Hospital of Traditional Chinese Medicine

Trichloroethylene induced hypersensitivity syndrome is dose-independent and potentially life threatening disease, which has become one of the serious occupational health issues and requires intensive treatment. To discover the genetic risk factors and evaluate the performance of risk prediction model for the disease, we conducted genomewide association study and replication study with total of 174 cases and 1761 trichloroethylene-tolerant controls. Fifty seven SNPs that exceeded the threshold for genome-wide significance (P < 5 × 10(-8)) were screened to relate with the disease, among which two independent SNPs were identified, that is rs2857281 at MICA (odds ratio, 11.92; Pmeta = 1.33 × 10(-37)) and rs2523557 between HLA-B and MICA (odds ratio, 7.33; Pmeta = 8.79 × 10(-35)). The genetic risk score with these two SNPs explains at least 20.9% of the disease variance and up to 32.5-fold variation in inter-individual risk. Combining of two SNPs as predictors for the disease would have accuracy of 80.73%, the area under receiver operator characteristic curves (AUC) scores was 0.82 with sensitivity of 74% and specificity of 85%, which was considered to have excellent discrimination for the disease, and could be considered for translational application for screening employees before exposure.

Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome.

This study aims to evaluate the effectiveness of breast magnetic resonance imaging (MRI) in detecting residual breast cancer in patients after vacuum-assisted breast biopsy (VABB).

Role of Magnetic Resonance Imaging in Predicting Residual Breast Cancer After Vacuum-Assisted Breast Biopsy.

In order to avoid excessive treatment of thyroid nodules in the clinic, it is necessary to find a simple and practical analysis method to comprehensively and accurately reflect benign or malignant thyroid nodules. This study aimed to construct and validate a comprehensive and reliable network-based predictive model using a variety of imaging and laboratory criteria for thyroid nodules to stratify the risk of malignancy prior to surgery.

Preoperative comprehensive malignancy risk estimation for thyroid nodules: Development and verification of a network-based prediction model.

To prevent the overaggressive treatment of axillary lymph nodes (ALNs) in breast cancer, it is necessary to develop a convenient analysis method that accurately and comprehensively reflects whether ALNs are metastatic or nonmetastatic. We retrospectively analyzed data from patients who underwent surgery for breast cancer at the Weifang Hospital of Traditional Chinese Medicine between January 2019 and June 2023. Binary logistic regression analysis was used to predict the metastasis status of ALNs. The developmental data set included 531 patients (January 2019-June 2023). The validation set included separate data points (n = 178, January 2019-June 2023). Multivariate analysis revealed that positive findings on breast physical examination, ultrasound grades of ALNs, lymphovascular invasion, and Her-2 status had significant predictive value for metastatic ALNs. Based on these findings, a 5-grade risk scoring system and 3-level management recommendations were developed. The risk of metastasis ranged from 11.25 to 93.46%, which was positively correlated with an increase in risk grade. The areas under the curve of the development and validation sets were 0.895 and 0.865, respectively. Ultimately, a convenient, accurate and comprehensive web-based predictive model was constructed using various breast cancer clinical, imaging and pathological criteria to stratify ALNs according to the metastasis probability.

Preoperative comprehensive risk estimation for axillary lymph node metastasis in breast cancer: development and verification of a network-based prediction model.

Article	Year
Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome. Scientific reports\| PubMed ID: 26190474	2015
Role of Magnetic Resonance Imaging in Predicting Residual Breast Cancer After Vacuum-Assisted Breast Biopsy. The American surgeon\| PubMed ID: 33284052	2021
Preoperative comprehensive malignancy risk estimation for thyroid nodules: Development and verification of a network-based prediction model. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology\| PubMed ID: 35367109	2022
Preoperative comprehensive risk estimation for axillary lymph node metastasis in breast cancer: development and verification of a network-based prediction model. Scientific reports\| PubMed ID: 39789023	2025

Mingming Shi

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