an-animal-model-pulpitis-based-on-an-outbred-mice-strain-its

An Animal Model of Pulpitis Based on an Outbred Mice Strain and Its Histological Analysis

The Naval Medical Research Institute (NMRI) mice have not been reported previously for creating a dental pulp inflammation model. In this protocol, we ...

Dow University of Health Sciences

Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth.

Effect of bisphosphonates on root resorption after tooth replantation - a systematic review.

This in vivo animal study aimed to develop a murine model of pulpitis induced by pulp exposure with or without application of zymosan in Naval Medical Research Institute (NMRI) mice and observe expressions of Toll-like receptor (TLR)-2, TLR-4, Dectin-1, Osteopontin (OPN), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1ß.

Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis.

Toll like receptors (TLR) 2 and 4 present on innate immune cells of the dental pulp detect cariogenic bacteria. Along with bacteria, C. albicans may also be present in dental caries. The presence of C. albicans can be detected by Dectin-1 a C type Lectin receptor. Expression of Dectin-1 in human pulpits has not been reported. Similarly, cytokines are released as a consequence of dental pulp inflammation caused by cariogenic bacteria. The T helper (Th) 1 inflammatory response leads to exacerbation of inflammation and its relationship with Osteopontin (OPN) is not known in pulp inflammation.

Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo.

Candida albicans is linked to persistent endodontic lesions. However, the recognition receptor that identifies it is not explored previously.

A novel experimental model to investigate fungal involvement shows expression of Dectin-1 in periapical lesion pathogenesis.

Glutathione peroxidase 1 (GPX1) and GPX4 are abundant antioxidant enzymes within the cytosol in mammalian tissues. These enzymes have the capacity to scavenge free radicals, and they play roles in various cancers, especially oral squamous cell carcinoma (OSCC).

Assessment of glutathione peroxidase 1 and 4 expression in oral squamous cell carcinoma patients in a tertiary care center: A comparative cross-sectional study.

To observe the association between Aldehyde dehydrogenase 3 family member A1 (ALDH3A1) levels with histological grade, pathological stage and nodal status in Oral Squamous Cell Carcinoma (OSCC).

Article	Year
Effect of bisphosphonates on root resorption after tooth replantation - a systematic review. Dental traumatology : official publication of International Association for Dental Traumatology\| PubMed ID: 27960049	2017
Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis. Clinical oral investigations\| PubMed ID: 36205788	2023
Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo. BMC oral health\| PubMed ID: 36463168	2022
A novel experimental model to investigate fungal involvement shows expression of Dectin-1 in periapical lesion pathogenesis. Journal of oral rehabilitation\| PubMed ID: 37263973	2023
Assessment of glutathione peroxidase 1 and 4 expression in oral squamous cell carcinoma patients in a tertiary care center: A comparative cross-sectional study. Journal of Taibah University Medical Sciences\| PubMed ID: 40612963	2025
Association of ALDH3A1 expression with tumor differentiation, pathological stage, and nodal status in oral squamous cell carcinoma. Journal of Taibah University Medical Sciences\| PubMed ID: 40657474	2025

Shazia Akbar Ansari

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