Saskia E.M. Schols

Department of Hematology, Radboud university medical center

Affiliated withRadboud university medical center Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Whole exome sequencing in the diagnostic workup of patients with a bleeding diathesis. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 30431218	2019
Iron handling by the human kidney: glomerular filtration and tubular reabsorption both contribute to urinary iron excretion. American journal of physiology. Renal physiology\| PubMed ID: 30623722	2019
Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab. Clinical pharmacokinetics\| PubMed ID: 30758736	2019
Thrombin and plasmin generation in patients with plasminogen or plasminogen activator inhibitor type 1 deficiency. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 31469483	2019
Diagnostic work up of patients with increased bleeding tendency. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 31886943	2020
Pregnancy outcome in afibrinogenemia: Are we giving enough fibrinogen concentrate? A case series. Research and practice in thrombosis and haemostasis\| PubMed ID: 32110766	2020
Platelet CD34 expression in a patient with a partial deletion of transcription factor subunit CBFB. American journal of hematology\| PubMed ID: 32124467	2020
Bleeding severity in patients with rare bleeding disorders: real-life data from the RBiN study. Blood advances\| PubMed ID: 33064819	2020
Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001-2018. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 33217158	2021
Adherence to prophylaxis and its association with activation of self-management and treatment satisfaction. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 34019720	2021
Health and treatment outcomes of patients with hemophilia in the Netherlands, 1972-2019. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 34117710	2021
Similar sports participation as the general population in Dutch persons with haemophilia; results from a nationwide study. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 34146370	2021
Validation of PROMIS Profile-29 in adults with hemophilia in the Netherlands. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 34245088	2021
Von Willebrand disease type 2M: Correlation between genotype and phenotype. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 34758185	2022
Hepatitis C virus in hemophilia: Health-related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study. Research and practice in thrombosis and haemostasis\| PubMed ID: 34870068	2021
Combining factor VIII levels and thrombin/plasmin generation: A population pharmacokinetic-pharmacodynamic model for patients with haemophilia A. British journal of clinical pharmacology\| PubMed ID: 34921439	2022
Thrombin generation for monitoring hemostatic therapy in hemophilia A: A narrative review. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 35034413	2022
Treatment of patients with rare bleeding disorders in the Netherlands: Real-life data from the RBiN study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 35038781	2022
Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study). TH open : companion journal to thrombosis and haemostasis\| PubMed ID: 35280975	2022
Von Willebrand disease type 2M: Correlation between genotype and phenotype: Reply to comment from Dr. Favaloro and to comment from Dr. Woods et al. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 35307943	2022
Fibrinolytic assays in bleeding of unknown cause: Improvement in diagnostic yield. Research and practice in thrombosis and haemostasis\| PubMed ID: 35316940	2022
Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease. Blood advances\| PubMed ID: 35446929	2022
Interaction of von Willebrand factor with blood cells in flow models: a systematic review. Blood advances\| PubMed ID: 35816358	2022
IRIDA Phenotype in Monoallelic-Affected Patients: Toward a Better Understanding of the Pathophysiology. Genes\| PubMed ID: 35893046	2022
Validation of the pedHAL and HAL in Dutch children and adults with haemophilia. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 35905309	2022
Socioeconomic participation of persons with hemophilia: Results from the sixth hemophilia in the Netherlands study. Research and practice in thrombosis and haemostasis\| PubMed ID: 36051543	2022
Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients. British journal of haematology\| PubMed ID: 36165954	2022
Thrombin generation assays to personalize treatment in bleeding and thrombotic diseases. Frontiers in cardiovascular medicine\| PubMed ID: 36440026	2022
Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 36696188	2023
High prevalence of postpartum hemorrhage in women with rare bleeding disorders in the Netherlands: retrospective data from the RBiN study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 36696205	2023
In patients with hemophilia, a decreased thrombin generation profile is associated with a severe bleeding phenotype. Research and practice in thrombosis and haemostasis\| PubMed ID: 36865907	2023
Effect of Eculizumab on Iron Metabolism in Transfusion-independent Patients With Paroxysmal Nocturnal Hemoglobinuria. HemaSphere\| PubMed ID: 37092027	2023
Erythropoiesis-hepcidin-iron axis in patients with X-linked sideroblastic anaemia: An explorative biomarker study. British journal of haematology\| PubMed ID: 37469032	2023
High prevalence of heavy menstrual bleeding in women with rare bleeding disorders in the Netherlands: retrospective data from the RBiN study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37517479	2023
Desmopressin in nonsevere hemophilia A: patient perspectives on use and efficacy. Research and practice in thrombosis and haemostasis\| PubMed ID: 37601028	2023
Transition readiness among adolescents and young adults with haemophilia in the Netherlands: Nationwide questionnaire study. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 37602825	2023
Patients with moderate hemophilia A and B with a severe bleeding phenotype have an increased burden of disease. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37813197	2024
The Nijmegen ultra-sensitive Bethesda Assay detects very low-titer factor VIII inhibitors in patients with congenital and acquired hemophilia A. Thrombosis research\| PubMed ID: 37844518	2023
Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies. Blood\| PubMed ID: 38142407	2024
Pharmacokinetic-Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate. European journal of drug metabolism and pharmacokinetics\| PubMed ID: 38367175	2024
The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A. Frontiers in immunology\| PubMed ID: 38455035	2024
Predictive performance of pharmacokinetic-guided prophylactic dosing of factor concentrates in hemophilia A and B. Research and practice in thrombosis and haemostasis\| PubMed ID: 38689619	2024
Comparative analysis of thrombin generation platforms for patients with coagulation factor deficiencies: A comprehensive assessment. Thrombosis research\| PubMed ID: 38834002	2024
Targeted exome analysis in patients with rare bleeding disorders: data from the Rare Bleeding Disorders in the Netherlands study. Research and practice in thrombosis and haemostasis\| PubMed ID: 39076726	2024
Psychometrics of patient-reported outcomes measurement information system in von Willebrand disease, inherited platelet function disorders, and rare bleeding disorders. Research and practice in thrombosis and haemostasis\| PubMed ID: 39076727	2024
Genetic variants, thrombocytopenia, and clinical phenotype of type 2B von Willebrand disease: a median 16-year follow-up study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 39343102	2024
Patient-reported data on the severity of Von Willebrand disease. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 39403864	2024
Prediction of the chance of successful immune tolerance induction in persons with severe hemophilia A and inhibitors: a clinical prediction model. Research and practice in thrombosis and haemostasis\| PubMed ID: 39558913	2024
Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin-deficient patients: Data from the Rare Bleeding disorders in the Netherlands study. Research and practice in thrombosis and haemostasis\| PubMed ID: 39628652	2024
Bleeding disorder of unknown cause: an illustrated review on current practice, knowledge gaps, and future perspectives. Research and practice in thrombosis and haemostasis\| PubMed ID: 39687924	2024
Bleeding symptoms in persons with rare bleeding disorders and a heterozygous genotype: data from the Rare Bleeding Disorders in the Netherlands study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 40056984	2025
Phenotype, genotype, and laboratory assessment of congenital fibrinogen disorders: Data from the Rare Bleeding disorders in the Netherlands study. Thrombosis research\| PubMed ID: 40203550	2025
Sexuality and bleeding in von Willebrand disease. Research and practice in thrombosis and haemostasis\| PubMed ID: 40224273	2025
Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF. Blood\| PubMed ID: 40279514	2025
Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey. Haemophilia : the official journal of the World Federation of Hemophilia\| PubMed ID: 40421900	2025
Impaired tolerance in the International Immune Tolerance Induction study due to the presence of very low-titer inhibitors. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 40701257	2025
Health-related quality of life in rare bleeding disorders: results from the Rare Bleeding Disorders in the Netherlands study. Research and practice in thrombosis and haemostasis\| PubMed ID: 40735298	2025
Viscoelastic testing in patients with very rare bleeding disorders of secondary hemostasis, a scoping review. Thrombosis research\| PubMed ID: 40915255	2025
Branched endovascular aneurysm repair complicated by disseminated intravascular coagulation while using tocilizumab. Journal of vascular surgery cases and innovative techniques\| PubMed ID: 41018205	2025
Measuring FVIII Activity and Thrombin Generation Simultaneously With a Novel Point of Care Platform (EnzySystem HemA): Qualitative Usability Evaluation. JMIR formative research\| PubMed ID: 41100594	2025
Pharmacokinetic-guided dose reduction of emicizumab in congenital hemophilia A: interim analysis of the DosEmi study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 41207564	2025
Large deletions in the gene predict immune tolerance induction failure in people with severe hemophilia A. Research and practice in thrombosis and haemostasis\| PubMed ID: 41246453	2025
Thrombin generation profiling in rare coagulation factor deficiencies: associations with bleeding severity and potential for screening. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 41443372	2025
Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms. Research and practice in thrombosis and haemostasis\| PubMed ID: 41476895	2025
Non-Coding Variants in the Expression of Iron Refractory Iron Deficiency Anemia in Monoallelic Subjects. Genes\| PubMed ID: 41595494	2026
Direct oral anticoagulant interference and removal in the factor VIII inhibitor assay. Research and practice in thrombosis and haemostasis\| PubMed ID: 41624237	2026
Monitoring the Hemostatic Balance: measuring thrombin generation in a patient with acquired hemophilia A on combined pro- and anticoagulant therapy. Thrombosis research\| PubMed ID: 41650515	2026
A chemiluminescent microfluidic thrombin generation assay for real-time monitoring in patient plasma. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 41692093	2026