a-rat-model-tibial-cortex-transverse-transport-for-treatment-lower

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

Tibial cortex transverse transport (TTT) is an emerging surgical technique used to promote revascularization in ischemic lower limbs. This video ...

The First Affiliated Hospital of Guangxi Medical University

Guangxi Medical University

The treatment of recalcitrant not-diabetic leg ulcers remains challenging. Distraction osteogenesis is accompanying by angiogenesis and neovascularization in the surrounding tissues. We previously applied tibial cortex transverse transport (TTT) to patients with recalcitrant diabetic foot ulcers and found neovascularization and increased perfusion in the foot and consequently enhanced healing and limb salvage and reduced recurrence. However, the effects of TTT on recalcitrant non-diabetic leg ulcer remains largely unknown.

Tibial cortex transverse transport facilitating healing in patients with recalcitrant non-diabetic leg ulcers.

To investigate the effectiveness of tibial transverse transport (TTT) combined with nose ring drain (NRD) in the treatment of severe diabetic foot ulcer.

[Treatment of severe diabetic foot ulcer using tibia transverse transport combined with nose ring drain].

Osteoblasts-Osteoclasts has been a major area in bone disease research for a long time. However, there are few systematic studies in this field using bibliometric analysis. We aimed to perform a bibliometric analysis and visualization study to determine hotspots and trends of osteoblasts-osteoclasts in bone diseases, identify collaboration and influence among authors, countries, institutions, and journals, and assess the knowledge base to develop basic and clinical research in the future.

Knowledge Domains and Emerging Trends of Osteoblasts-Osteoclasts in Bone Disease From 2002 to 2021: A Bibliometrics Analysis and Visualization Study.

Tibial Cortex Transverse Transport (TTT) has been demonstrated to be an effective treatment for unilateral diabetic foot ulcers (UDFUs). However, this retrospective study was designed to compare the efficacy and safety of unilateral TTT on bilateral diabetic foot ulcers (BDFUs).

Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study.

Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing an animal model that closely mirrors clinical scenarios is both critical and novel for elucidating the mechanisms of TTT.

Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model.

Management of severe diabetic foot ulcers (DFUs) remains challenging. Tibial cortex transverse transport (TTT) facilitates healing and limb salvage in patients with recalcitrant DFUs. However, the underlying mechanism is largely unknown, necessitating the establishment of an animal model and mechanism exploration.

Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1α-Induced Angiogenesis.

Diabetic foot ulcers (DFUs) represent one of the most severe late-stage complications of diabetes. Tibial cortex transverse transport (TTT) surgery stands as the prevailing method for addressing DFUs. This surgical intervention holds the promise of expediting DFU wound healing and diminishing the rate of amputations, with the mitigation of inflammatory responses playing a pivotal role. In this study, we aim to explore the correlation between inflammation and TTT surgery, with the overarching goal of facilitating swift prognostic assessments in clinical practice.

Correlation analysis of patients with diabetic foot ulcers treated with tibial cortex transverse transport surgery and platelet-to-lymphocyte ratio and monocyte-to-neutrophil ratio.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and joint destruction. Although the roles of inflammatory cytokines and metabolites in RA pathogenesis have caught a lot of attention, there is a lack of systematic studies, and their causal relationships remain unclear.

Inflammatory cytokines, metabolites, and rheumatoid arthritis.

Tibial cortex transverse transport (TTT) represents an innovative surgical technique used in managing lower limb ischaemic conditions, focusing specifically on diabetic foot ulcers. This study aimed to assess the safety of TTT by evaluating the stress magnitude and distribution on the tibia and tibial osteotomy blocks.

Finite element analysis safety of tibial cortex transverse transport.

This study aims to compare the effects of tibial cortex transverse transport (TTT) and platelet-rich plasma (PRP) on the healing of severe diabetic foot ulcers, evaluate the clinical efficacy of TTT, and explore its potential impact on lower limb circulation.

Comparison of clinical efficacy between tibial cortex transverse transport and platelet-rich plasma treatment for severe diabetic foot ulcers.

Diabetic foot ulcer (DFU) poses a major clinical burden. This study, for the first time, establishes and validates a finite element (FE) biomechanical model of tibial cortex transverse transport (TTT) in diabetic rats. By integrating micro-CT data at multiple time points, we provide a novel computational approach to assess the biomechanical safety and stability of TTT, thus bridging preclinical animal research and potential clinical translation.

Article	Year
Tibial cortex transverse transport facilitating healing in patients with recalcitrant non-diabetic leg ulcers. Journal of orthopaedic translation\| PubMed ID: 33344165	2021
[Treatment of severe diabetic foot ulcer using tibia transverse transport combined with nose ring drain]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery\| PubMed ID: 34387426	2021
Knowledge Domains and Emerging Trends of Osteoblasts-Osteoclasts in Bone Disease From 2002 to 2021: A Bibliometrics Analysis and Visualization Study. Frontiers in endocrinology\| PubMed ID: 35937845	2022
Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study. Journal of orthopaedic translation\| PubMed ID: 37736148	2023
Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model. European journal of medical research\| PubMed ID: 38449025	2024
Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1α-Induced Angiogenesis. Journal of inflammation research\| PubMed ID: 38707956	2024
Correlation analysis of patients with diabetic foot ulcers treated with tibial cortex transverse transport surgery and platelet-to-lymphocyte ratio and monocyte-to-neutrophil ratio. Advances in clinical and experimental medicine : official organ Wroclaw Medical University\| PubMed ID: 38934335	2025
Inflammatory cytokines, metabolites, and rheumatoid arthritis. Postgraduate medical journal\| PubMed ID: 39475124	2025
Finite element analysis safety of tibial cortex transverse transport. Bone & joint research\| PubMed ID: 40164177	2025
Comparison of clinical efficacy between tibial cortex transverse transport and platelet-rich plasma treatment for severe diabetic foot ulcers. Frontiers in surgery\| PubMed ID: 40166622	2025
Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport. Frontiers in bioengineering and biotechnology\| PubMed ID: 41311977	2025
Global epidemiology and burden of multiple myeloma from 1990 to 2021 with projections to 2045 based on the global burden of disease study 2021. Discover oncology\| PubMed ID: 41680588	2026

Hongjie Su

Biography

JoVE Journal Publications

Other Publications