a-rat-model-tibial-cortex-transverse-transport-for-treatment-lower

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

Tibial cortex transverse transport (TTT) is an emerging surgical technique used to promote revascularization in ischemic lower limbs. This video ...

The First Affiliated Hospital of Guangxi Medical University

Guangxi Medical University

The clinical management of patients with chronic limb-threatening ischemia (CLTI) faces great challenges. Enhancing wound healing and limb preservation rates in this cohort is a critical objective. This study investigates the effectiveness of combining tibial cortex transverse transport (TTT) and endovascular therapy (EVT) for the treatment of patients with severe CLTI. We aim to evaluate the therapeutic results of this combined approach on the specified patient group.

Combining Tibial Cortex Transverse Transport (TTT) and Endovascular Therapy (EVT) for Limb Salvage in Chronic Limb-Threatening Ischemia.

To provide a comprehensive summary of the technological evolution, clinical protocols, mechanisms of action, and current research progress of tibial transverse transport (TTT), with the goal of facilitating its standardized application in clinical practice.

[Research advances in limb salvage treatment of diabetic foot using tibial transverse transport].

Obesity is a prevalent and clinically significant complication among individuals with diabetes mellitus (DM), contributing to increased cardiovascular risk, metabolic burden, and reduced quality of life. Despite its high prevalence, the risk factors for obesity within this population remain incompletely understood. With the growing availability of large-scale health datasets and advancements in machine learning, there is an opportunity to improve risk stratification. This study aimed to identify key predictors of obesity and develop a machine learning-based predictive model for patients with T2DM using data from the National Health and Nutrition Examination Survey (NHANES).

A machine learning model for predicting obesity risk in patients with diabetes mellitus: analysis of NHANES 2007-2018.

Diabetic foot ulcer (DFU) poses a major clinical burden. This study, for the first time, establishes and validates a finite element (FE) biomechanical model of tibial cortex transverse transport (TTT) in diabetic rats. By integrating micro-CT data at multiple time points, we provide a novel computational approach to assess the biomechanical safety and stability of TTT, thus bridging preclinical animal research and potential clinical translation.

Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading chronic liver disorder closely linked to diabetes mellitus (DM) and its cardiovascular and renal complications. Early identification of diabetes risk in this population is essential for timely intervention.

Development of a machine learning-based model for prediction of diabetes risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Article	Year
Combining Tibial Cortex Transverse Transport (TTT) and Endovascular Therapy (EVT) for Limb Salvage in Chronic Limb-Threatening Ischemia. Orthopaedic surgery\| PubMed ID: 39243174	2024
[Research advances in limb salvage treatment of diabetic foot using tibial transverse transport]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery\| PubMed ID: 40830117	2025
A machine learning model for predicting obesity risk in patients with diabetes mellitus: analysis of NHANES 2007-2018. Frontiers in public health\| PubMed ID: 40917432	2025
Finite element analysis of biomechanical effects in rat tibia during tibial cortex transverse transport. Frontiers in bioengineering and biotechnology\| PubMed ID: 41311977	2025
Development of a machine learning-based model for prediction of diabetes risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). BMJ open\| PubMed ID: 41605598	2026

Ruiqing Mo

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