a-quantitative-measurement-ocular-rotation-small-incision-lenticule

A Quantitative Measurement of Ocular Rotation in Small Incision Lenticule Extraction: Double Marking of Corneal Limbus and Sclera

The small incision lenticule extraction (SMILE) has become a mainstream surgical procedure for correcting myopia and astigmatism. Nevertheless, the lack ...

Second Affiliated Hospital of Guizhou Medical University

Guizhou Medical University

Threatened miscarriage occurs in 10% to 15% of all pregnancies. Vaginal spotting or bleeding during early gestation is common, with nearly half of those pregnancies resulting in pregnancy loss. To date, there is no effective preventive treatment for threatened miscarriage. Chinese herbal medicines have been widely used in Asian countries for centuries and have become a popular alternative to Western medicines in recent years. Many studies claim to show that they can prevent miscarriage. However, there has been no systematic evaluation of the effectiveness of Chinese herbal medicines for threatened miscarriage.

Chinese herbal medicines for threatened miscarriage.

Aberrant lipid metabolism is intimately linked to tumor progression. As a pivotal post-translational modification, ubiquitination regulates diverse oncogenic processes. However, the interplay between ubiquitination and lipid metabolic dysregulation in pancreatic cancer (PC), along with its underlying molecular mechanisms, remains poorly understood. Here, it is demonstrated that glycolytic enzyme lactate dehydrogenase A (LDHA) potentiates lipid biosynthesis under the regulation of deubiquitinases. Specifically, PSMD14 directly binds and stabilizes LDHA through its deubiquitinase activity, resulting in intracellular lactate accumulation. Elevated lactate levels enhance histone lactylation marks, which transcriptionally activate ATP citrate lyase (ACLY) to promote malignant progression via fatty acid synthesis pathway activation. This study reveals a previously unrecognized role of PSMD14-derived lactate in mediating histone lactylation-coupled lipid deposition and tumor progression. Therapeutic co-targeting of PSMD14 and glycolytic lactylation significantly suppresses tumor growth in patient-derived xenograft models, suggesting a promising combinatorial strategy for pancreatic cancer treatment.

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

The aim of this study was to conduct a systematic investigation into the effects of ocular rotation on postoperative residual astigmatism in patients undergoing small incision lenticule extraction (SMILE).

Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction.

Article	Year
Chinese herbal medicines for threatened miscarriage. The Cochrane database of systematic reviews\| PubMed ID: 22592730	2012
PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 41051446	2025
Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction. Frontiers in cell and developmental biology\| PubMed ID: 41425087	2025

Chi Wang

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