a-quantitative-measurement-ocular-rotation-small-incision-lenticule

A Quantitative Measurement of Ocular Rotation in Small Incision Lenticule Extraction: Double Marking of Corneal Limbus and Sclera

The small incision lenticule extraction (SMILE) has become a mainstream surgical procedure for correcting myopia and astigmatism. Nevertheless, the lack ...

Second Affiliated Hospital of Guizhou Medical University

Guizhou Medical University

To investigate the characteristics of intraocular pressure (IOP) measurements using the Icare HOME rebound tonometer (RBT) and non-contact tonometer (NCT) during the early stage after implantable collamer lens (ICL) V4c implantation, and to assess the agreement between the two methods.

Comparison of Icare HOME and non-contact tonometer in intraocular pressure measurement in the early stage after ICL V4c implantation.

The aim of this study was to conduct a systematic investigation into the effects of ocular rotation on postoperative residual astigmatism in patients undergoing small incision lenticule extraction (SMILE).

Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction.

Matrix metalloproteinases (MMPs) have been increasingly recognized as potential contributors or mediators in the pathogenesis of diabetic retinopathy (DR). Nevertheless, the relationships among MMPs and the risk of DR have not been definitively elucidated and still require further investigation. The bidirectional two-sample Mendelian randomization (MR) analyses were implemented to evaluate the causal effect of MMPs (specifically, MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12, MMP-13, MMP-14, MMP-16, and MMP-17) on DR. The inverse variance weighted (IVW) served as the primary MR method, accompanied by sensitivity analyses to verify the result stability. In the forward MR analyses, genetically predicted MMP-7 was associated with an increased risk of DR (IVW: odds ratio = 1.15; 95% confidence interval: 1.05-1.25; P = 2.759 × 10⁻³]. In contrast, higher MMP-8 were robustly associated with a reduced risk of DR (IVW: odds ratio = 0.86; 95% confidence interval: 0.82-0.91; P = 5.506 × 10⁻⁸). No significant causal associations were observed between DR and the remaining MMPs. Sensitivity analyses revealed that the causal estimate for MMP-7 was sensitive to the threshold used for instrumental variables, whereas the association for MMP-8 was largely driven by 1 single nucleotide polymorphism (rs12614). In the reverse MR analyses, no significant causal effects of DR on any of the MMPs were detected after correction for multiple testing. This study provides preliminary and exploratory evidence supporting a causal association between MMPs and DR risk in European population. Specifically, MMP-7 may be associated with an increased risk of DR, while MMP-8 may be protective against DR. These findings suggest distinct pathophysiological roles for specific MMPs in DR development. However, given the exploratory nature of the analysis, further validation in mechanistic and longitudinal studies is warranted. not applicable.

Article	Year
Comparison of Icare HOME and non-contact tonometer in intraocular pressure measurement in the early stage after ICL V4c implantation. European journal of ophthalmology\| PubMed ID: 35422146	2022
Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction. Frontiers in cell and developmental biology\| PubMed ID: 41425087	2025
Causal relationship between matrix metalloproteinases and diabetic retinopathy: A bidirectional two-sample Mendelian randomization study. Medicine\| PubMed ID: 41578579	2026

Fangwen Yang

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