animal-models-for-long-term-functional-recovery-rehabilitation-after

Animal Models for Long-Term Functional Recovery and Rehabilitation After Ischemic Stroke: Beyond Acute Neuroprotection

Ischemic stroke is one of the leading causes of long-term disability worldwide. Although acute neuroprotection strategies have been extensively studied, ...

Shandong University of Traditional Chinese Medicine

Metastasis, a leading cause of cancer-related deaths, involves complex mechanisms. The premetastatic niche (PMN) is a crucial contributor to this process. Myeloid-derived suppressor cells (MDSCs) play an important role in PMN formation and promote tumor progression and metastasis. The Xiaoliu Pingyi recipe (XLPYR), a traditional Chinese medicine, is effective in preventing postoperative recurrence and metastasis in cancer patients.

Xiaoliu Pingyi Pecipe Inhibits Lung Pre-Metastatic Niche Formation and Prevents Myeloid-Derived Suppressor Cells Recruitment.

Cancer is a major global health concern, and immune checkpoint inhibitors (ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can be influenced by various factors, including the use of concomitant medications.

Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review.

 The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear.  Genome-wide association study data on low-density lipoprotein (LDL), apolipoprotein B (ApoB), and triglycerides (TG) were used to develop genetic instrumental variables (IVs) for LLDs. Two-step Mendelian randomization analyses were performed to examine the causal relationship between LLDs and lung cancer risk. The effects of ceramide, sphingosine-1-phosphate (S1P), and ceramidases on lung cancer risk were explored, and the proportions of the effects of LLDs on lung cancer risk mediated by sphingolipid metabolism were calculated.   inhibition decreased the lung cancer risk in ever-smokers via ApoB (odds ratio [OR] 0.81, 95% confidence interval [CI] 0.70-0.92,  = 0.010), LDL (OR 0.82, 95% CI 0.71-0.96,  = 0.040), and TG (OR 0.63, 95% CI 0.46-0.83,  = 0.015) reduction by 1 standard deviation (SD), decreased small-cell lung cancer (SCLC) risk via LDL reduction by 1 SD (OR 0.71, 95% CI 0.56-0.90,  = 0.016), and decreased the plasma ceramide level and increased the neutral ceramidase level.  inhibition decreased the lung adenocarcinoma (LUAD) risk (OR 0.60, 95% CI 0.43-0.84,  = 0.039) but increased SCLC risk (OR 2.18, 95% CI 1.17-4.09,  = 0.029) via ApoB reduction by 1 SD.  inhibition increased SCLC risk via ApoB reduction by 1 SD (OR 3.04, 95% CI 1.38-6.70,  = 0.014). The  agonist decreased SCLC risk via ApoB (OR 0.20, 95% CI 0.07-0.58,  = 0.012) and TG reduction (OR 0.58, 95% CI 0.43-0.77,  = 0.003) while increased the plasma S1P level.  inhibition decreased the ceramide level. Neutral ceramidase mediated 8.1% and 9.5% of the reduced lung cancer risk in ever-smokers via ApoB and TG reduction by  inhibition, respectively, and mediated 8.7% of the reduced LUAD risk via ApoB reduction by  inhibition.  We elucidated the intricate interplay between LLDs, sphingolipid metabolites, and lung cancer risk. Associations of , , and  inhibition and  agonist with distinct lung cancer risks underscore the multifaceted nature of these relationships. The observed mediation effects highlight the considerable influence of neutral ceramidase on the lung cancer risk reduction achieved by  and  inhibition.

Lipid-lowering drugs affect lung cancer risk via sphingolipid metabolism: a drug-target Mendelian randomization study.

Knee osteoarthritis (KOA) is a prevalent degenerative bone and joint disease observed in clinical practice. While acupuncture has demonstrated efficacy in treating KOA, the central mechanisms underlying its effects remain ambiguous. Recently, functional magnetic resonance imaging (fMRI) has been extensively applied in studying the brain mechanisms of acupuncture analgesia. Currently, network analysis based on brain connectomics is a focal point in acupuncture imaging research. Therefore, this study uses KOA as the research vehicle, focuses on the abnormal connectivity patterns of brain functional networks, and integrates clinical pain assessments to thoroughly investigate the central mechanisms of acupuncture therapeutic effects on KOA.

Article	Year
Xiaoliu Pingyi Pecipe Inhibits Lung Pre-Metastatic Niche Formation and Prevents Myeloid-Derived Suppressor Cells Recruitment. Integrative cancer therapies\| PubMed ID: 37431869	2023
Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review. Frontiers in immunology\| PubMed ID: 37841249	2023
Lipid-lowering drugs affect lung cancer risk via sphingolipid metabolism: a drug-target Mendelian randomization study. Frontiers in genetics\| PubMed ID: 38034491	2023
The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial. Journal of pain research\| PubMed ID: 39872091	2025

Ruohan Zhao

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