animal-models-for-long-term-functional-recovery-rehabilitation-after

Animal Models for Long-Term Functional Recovery and Rehabilitation After Ischemic Stroke: Beyond Acute Neuroprotection

Ischemic stroke is one of the leading causes of long-term disability worldwide. Although acute neuroprotection strategies have been extensively studied, ...

Shandong University of Traditional Chinese Medicine

Anorexia of aging (AA) is a common geriatric syndrome that seriously endangers the health of older adults. Early identification of populations at risk of AAand the implementation of appropriate intervention measures hold significant public health importance. This study aimed to develop a nomogram for predicting the risk of AA among older people.

Development and validation of a nomogram for predicting anorexia of aging in older people.

Frailty is a common geriatric syndrome in older adults; however, its relationship with digital factors is underexplored. This study aimed to examine the association between digital skills, eHealth literacy, and frailty to provide insights for developing frailty interventions in the digital age.

Associations between Digital Skill, eHealth Literacy, and Frailty among Older Adults: Evidence from China.

This article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that plant natural products (such as hesperidin, curcumin, Epimedin B, etc.) can improve bone metabolism imbalance and delay the process of bone aging by regulating inflammatory factors (TNF-α, IL-1β) and antioxidant pathways (Nrf2/HO-1). Osteoporosis and cartilage damage promote each other to form a vicious cycle, and the intervention of plant active ingredients can target this common pathological process. Based on the current evidence, the strategy of combining anti-inflammation, anti-oxidation and mechanical regulation may provide a new direction for the prevention and treatment of bone aging-related diseases.

Article	Year
Development and validation of a nomogram for predicting anorexia of aging in older people. Appetite\| PubMed ID: 39029530	2024
Associations between Digital Skill, eHealth Literacy, and Frailty among Older Adults: Evidence from China. Journal of the American Medical Directors Association\| PubMed ID: 39307173	2024
From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging. Frontiers in endocrinology\| PubMed ID: 40704144	2025

Shengkai Zhang

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