a-lip-fixation-device-facilitates-labial-salivary-gland-biopsy-for

A Lip Fixation Device Facilitates Labial Salivary Gland Biopsy for Sj&#246;gren's Disease

The protocol aims to standardize and simplify labial salivary gland biopsy (LSGB) in suspected Sj&#246;gren&#39;s disease (SjD) using a lip fixation ...

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

The purpose of this study was to investigate the baseline independent risk factors for predicting 6-month mortality of patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5)-positive dermatomyositis (DM) and develop a matrix prediction model formed by these risk factors.

A Matrix Prediction Model for the 6-Month Mortality Risk in Patients With Anti-Melanoma Differentiation-Associated Protein-5-Positive Dermatomyositis.

To characterize BMI in Chinese patients with RA  US patients and examine its association with joint damage in Chinese patients.

Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis.

The aim of this study is to investigate whether the testing time for unstimulated whole salivary flow (UWSF) can be shortened to 5 min in patients with suspected Sjögren's syndrome (SjS); and which SjS patients can use UWSF to evaluate salivary gland (SG) secretory function.

Can unstimulated whole salivary flow objectively classify salivary gland secretory function in Sjögren's syndrome?

To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA)  American patients and investigate their associated factors.

Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study.

Early menopause (EM, age ≤ 45 years) is associated with an increased risk of developing rheumatoid arthritis (RA). We aimed to investigate its impact on disease characteristics in RA patients.

Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis.

: Sarcopenia is a notable comorbidity of rheumatoid arthritis (RA), affecting about one third of patients. However, the characteristic of muscle function and its association with RA disease remains unknown. : This cross-sectional study collected clinical data from a real-world Chinese RA cohort. Sarcopenia was defined as both myopenia and low muscle function (LMF). Myopenia was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m in men and <5.7 kg/m in women. LMF was defined as low muscle strength (LMS, hand grip < 28 kg in men and <18 kg in women) or low physical performance (LPP, 6 m gait speed < 1.0 m/s). : Among 1125 RA patients recruited in this study, 928 RA patients were eligible for analysis. The prevalence of sarcopenia, myopenia, LMF, LMS, and LPP in all RA patients was 36.5%, 46.1%, 69.0%, 57.8%, and 37.1%, respectively. According to their trends in age and disease activity, there were 111 (11.9%) patients in the young (age < 50 years) and remission (CDAI ≤ 2.8) subgroup, 199 (21.4%) patients in the young and active (CDAI > 2.8) subgroup, 198 (21.3%) patients in the old (age ≥ 50 years) and remission subgroup, and 420 (45.2%) patients in the old and active subgroup. Compared with the two remission subgroups, respectively, the young and active subgroup had significantly lower grip strength, higher prevalence of sarcopenia, LMF, and LMS, and worse activity function. After adjustment for potential confounders, multivariate multinominal logistic regression analysis showed that the young and active subgroup was positively associated with sarcopenia (OR = 3.193, 95%CI: 1.477-6.899), LMF (OR = 2.390, 95%CI: 1.207-4.731), and LMS (OR = 3.520, 95%CI: 1.743-7.110). : Worse muscle strength, rather than reduced physical performance, is more common in patients with active RA at a young age. It underscores the critical need for early identification and intervention of muscle dysfunction to improve their quality of life.

The Characteristic of Muscle Function for Sarcopenia in Patients with Rheumatoid Arthritis: A Large-Scale Real-World Cross-Sectional Study.

The burden of rheumatoid arthritis (RA) is profound, although treated with the treat-to-target strategy for RA patients according to the two most influential organisations for rheumatology worldwide. The need to timely achieve the control of disease activity for RA patients, especially for those difficult-to-treat individuals, is still unmet. Besides, the data on the diagnosis and prognosis of RA-related complications or comorbidities such as sarcopenia, cardiovascular diseases (CVD), malignancies and infections in large real-world cohorts are still limited. Therefore, the aim of this large-scale cohort study is to identify the development of clinical, biomedical, histopathological and imaging biomarkers for the diagnosis and prognosis of difficult-to-treat RA, and RA-related complications/comorbidities and to evaluate their impact on the prognosis of RA.

Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study.

Muscle loss is linked to multiple adverse outcomes, but its impact on rheumatoid arthritis (RA) prognosis is unclear. This study aimed to examine the association between muscle mass and mortality in RA patients.

Impact of muscle mass on mortality in patients with rheumatoid arthritis: insights from NHANES 1999-2018.

While systemic muscle loss is associated with physical dysfunction, the role of localized upper extremities muscle deterioration in hand disability remains unclear in rheumatoid arthritis (RA). We aimed to explore the impact of low muscle mass in upper extremities on hand dysfunction in patients with RA.

Localized low muscle mass is associated with hand dysfunction beyond inflammation in rheumatoid arthritis: a cross-sectional study.

Cardiovascular diseases (CVD) are the predominant cause of death in arthritis patients. For Life's Crucial 9 (LC9), a newly proposed cardiovascular health metric, its association with mortality in the arthritis population and its prognostic value compared to the conventional Life's Simple 7 (LS7) and Life's Essential 8 (LE8) remain unclear.

Article	Year
A Matrix Prediction Model for the 6-Month Mortality Risk in Patients With Anti-Melanoma Differentiation-Associated Protein-5-Positive Dermatomyositis. Frontiers in medicine\| PubMed ID: 35433730	2022
Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis. Rheumatology advances in practice\| PubMed ID: 39055542	2024
Can unstimulated whole salivary flow objectively classify salivary gland secretory function in Sjögren's syndrome? Clinical rheumatology\| PubMed ID: 39373809	2024
Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study. PeerJ\| PubMed ID: 39713142	2024
Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis. BMC women's health\| PubMed ID: 40128824	2025
The Characteristic of Muscle Function for Sarcopenia in Patients with Rheumatoid Arthritis: A Large-Scale Real-World Cross-Sectional Study. Medicina (Kaunas, Lithuania)\| PubMed ID: 40282842	2025
Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study. BMJ open\| PubMed ID: 40659397	2025
Impact of muscle mass on mortality in patients with rheumatoid arthritis: insights from NHANES 1999-2018. Nutrition journal\| PubMed ID: 41199290	2025
Localized low muscle mass is associated with hand dysfunction beyond inflammation in rheumatoid arthritis: a cross-sectional study. PeerJ\| PubMed ID: 41669546	2026
Association of Life's Crucial 9 score with mortality among adults with arthritis: A prospective cohort analysis. Public health\| PubMed ID: 41734613	2026

Zhi-Ming Ouyang

Biography

JoVE Journal Publications

Other Publications