development-novel-internal-fixation-model-for-rat-radial-fractures

Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation

The rat radial fracture model is of significant importance in orthopedic research, particularly for studying fracture-healing mechanisms, drug screening, ...

Nanjing University of Chinese Medicine

To investigate the therapeutic effect and mechanism of Danggui Buxue Tang in the treatment of biceps longus tendon lesions, and to preliminarily explore the relevant factors affecting this injury.

Analysis of Pathological Factors of Long Head of Biceps Tendinopathy Based on Network Pharmacology.

Osteosarcoma (OS) is a malignant bone tumour that commonly occurs in paediatric and adolescent patients. Currently, effective therapy for OS remains elusive due to poor patient survival rates. In this study, we observed significantly elevated expressions of circTUBA1C in OS tumours and cells. Silencing circTUBA1C effectively suppressed proliferation and glucose metabolism, and promoted apoptosis of OS cells. Furthermore, we discovered that miR-143-3p played a reverse role to circTUBA1C in OS cells. Bioinformatics analysis, RNA pull-down assay, and luciferase assay demonstrated that circTUBA1C acted as a sponge for miR-143-3p, blocking its expression in OS cells. Finally, rescue experiments showed that inhibition of miR-143-3p in circTUBA1C-silenced OS cells significantly overrode the low-circTUBA1C-mediated miR-143-3p upregulation and OS cell progression in vitro and in vivo . Our results demonstrate the critical roles and molecular targets of circTUBA1C in modulating OS progression, suggesting that circTUBA1C inhibition could serve as a new therapeutic strategy for treating OS.

Article	Year
Analysis of Pathological Factors of Long Head of Biceps Tendinopathy Based on Network Pharmacology. Journal of musculoskeletal & neuronal interactions\| PubMed ID: 39219327	2024
CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p. Polish journal of pathology : official journal of the Polish Society of Pathologists\| PubMed ID: 39451176	2024

Yibing Liu

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