development-efficacy-enzyme-responsive-squalene-chidamide

Development and Efficacy of Enzyme-Responsive Squalene-Chidamide Nanoparticles for Pancreatic Cancer

Here, we present a protocol to address the limited intratumoral penetration of small-molecule drugs caused by the dense extracellular matrix (ECM) of ...

Zhejiang Chinese Medical University

Biofilms contribute to the persistence of infectious diseases, complicate the treatment of chronic infections and pose a significant global health threat. However, the effectiveness of antibacterial therapies is often limited by poor penetration of antibiotics, as well as the horizontal transfer of antibiotic resistance genes among bacteria. Phytochemicals remain a promising source for developing novel antibiofilm agents.

Natural phytochemical-based strategies for antibiofilm applications.

As a member of the Citrus genus of the Rutaceae family, Citrus changshan-huyou(CSHY) is mainly produced in Quzhou city, Zhejiang province. Modern research shows that different medicinal parts of CSHY(immature fruit, mature fruit peel, flower buds, leaves, seeds, etc.) are abundant in flavonoids, terpenes, coumarins, phenolic acids, and volatile oils. Their pharmacological activities include respiratory system protection, liver protection, anti-inflammation, anti-hyperlipidemia, anti-hyperglycemia, and antioxidation. Based on the summarization of 374 chemical components in different medicinal parts of CSHY identified in the past 20 years, this study reviewed their pharmacological actions and mechanisms and further analyzed the current status of quality control of different medicinal parts of CSHY, aiming to provide reference for the resource development and exploitation and the quality control research of different medicinal parts of CSHY.

[Research progress in chemical components and pharmacological activities of different medicinal parts of Citrus changshan-huyou].

Knee osteoarthritis (KOA) is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis, a central mechanism in KOA pathogenesis. Given the absence of disease-modifying therapies, there is a critical need to elucidate the underlying pathological processes, establish reliable biomarkers for early detection and prognosis, and identify safer, more effective therapeutic agents. In recent years, natural products have attracted considerable interest due to their low toxicity, cost-effectiveness, and distinct biological activities, demonstrating significant potential in KOA management. These compounds can impede KOA progression through multiple mechanisms, including promoting cartilage matrix synthesis, mitigating inflammation, reducing oxidative stress, suppressing chondrocyte apoptosis, and modulating autophagy, thereby supporting their translational application. This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA, with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products, such as flavonoids, alkaloids, saponins, terpenes, and traditional Chinese medicine (TCM) formulas, in KOA intervention, aiming to provide evidence-based strategies for improved disease management.

Article	Year
Natural phytochemical-based strategies for antibiofilm applications. Chinese medicine\| PubMed ID: 40597209	2025
[Research progress in chemical components and pharmacological activities of different medicinal parts of Citrus changshan-huyou]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica\| PubMed ID: 41084467	2025
Prevention and treatment of knee osteoarthritis by natural products: potential mechanisms based on articular cartilage targets. Chinese journal of natural medicines\| PubMed ID: 41708246	2026

Kangyu Zhou

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