Leonardo V. Riella

Center for Transplantation Sciences, Massachusetts General Hospital

Affiliated withMassachusetts General Hospital

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 22498498	2012
B7h (ICOS-L) maintains tolerance at the fetomaternal interface. The American journal of pathology\| PubMed ID: 23578385	2013
T-cell co-stimulatory blockade in kidney transplantation: back to the bench. Kidney international supplements\| PubMed ID: 25018899	2011
Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. PloS one\| PubMed ID: 25111080	2014
Incremental prognostic value of kidney function decline over coronary artery disease for cardiovascular event prediction after coronary computed tomography. Kidney international\| PubMed ID: 25629550	2015
Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25833841	2015
Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection. PloS one\| PubMed ID: 27415632	2016
Current status of alloimmunity. Current opinion in nephrology and hypertension\| PubMed ID: 27584931	2016
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27956634	2016
A Decision-Making Algorithm for Initiation and Discontinuation of RRT in Severe AKI. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 28119408	2017
Renal complications of immune checkpoint blockade. Current problems in cancer\| PubMed ID: 28189263	2017
Impact of environmental factors on alloimmunity and transplant fate. The Journal of clinical investigation\| PubMed ID: 28481225	2017
Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI insight\| PubMed ID: 28679959	2017
The outstanding questions in transplantation: It's about time…. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 28758364	2018
Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI insight\| PubMed ID: 29093262	2017
Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial. Kidney international reports\| PubMed ID: 30116795	2018
A large, international study on post-transplant glomerular diseases: the TANGO project. BMC nephrology\| PubMed ID: 30208881	2018
Chronic rejection of human face allografts. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 30312535	2019
Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 30803121	2019
The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. JAMA facial plastic surgery\| PubMed ID: 30998810	2019
APOL1-Associated Kidney Disease in Brazil. Kidney international reports\| PubMed ID: 31317114	2019
Noncirrhotic hyperammonemia after deceased donor kidney transplantation: A case report. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 31347272	2019
Recurrence of FSGS after Kidney Transplantation in Adults. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 31974287	2020
Impact of corticosteroids on allograft protection in renal transplant patients receiving anti-PD-1 immunotherapy. Cancer immunology, immunotherapy : CII\| PubMed ID: 32588077	2020
COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 32649791	2020
The COVID-19 pandemic: A community approach. Clinical transplantation\| PubMed ID: 32762055	2020
Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 32786152	2020
COVID-19 and the Kidneys: An Update. Frontiers in medicine\| PubMed ID: 32793615	2020
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response. Frontiers in immunology\| PubMed ID: 32849623	2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo. Scientific reports\| PubMed ID: 32859934	2020
Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 32892219	2021
A Comprehensive Phenotypic and Functional Immune Analysis Unravels Circulating Anti-Phospholipase A2 Receptor Antibody Secreting Cells in Membranous Nephropathy Patients. Kidney international reports\| PubMed ID: 33102969	2020
Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter. Science translational medicine\| PubMed ID: 33177180	2020
A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant. Kidney international\| PubMed ID: 33359528	2021
Circulating B Cells, Plasma Cells, and Treg Associate with ANCA Levels in ANCA-associated Vasculitis. Kidney international reports\| PubMed ID: 33615075	2021
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection. Journal of the American Society of Nephrology : JASN\| PubMed ID: 33658284	2021
Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. The Journal of clinical investigation\| PubMed ID: 33667197	2021
Face Transplantation in a Black Patient - Racial Considerations and Early Outcomes. The New England journal of medicine\| PubMed ID: 33730460	2021
Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study. PloS one\| PubMed ID: 33760858	2021
Posttransplant Lymphoproliferative Disorder Following Kidney Transplantation: A Review. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 33774079	2021
Preventing Coronavirus Disease 2019 in Kidney Transplant Recipients: Where Should We Begin? Nephron\| PubMed ID: 33789316	2021
Opioids and Kidney Transplantation. Seminars in nephrology\| PubMed ID: 33896473	2021
The failing kidney allograft: A review and recommendations for the care and management of a complex group of patients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 34115439	2021
T-cell Exhaustion in Organ Transplantation. Transplantation\| PubMed ID: 34115657	2022
Mineral Bone Disorders in Kidney Transplantation. Seminars in nephrology\| PubMed ID: 34140095	2021
Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study. Frontiers in immunology\| PubMed ID: 34149688	2021
Gene Expression Profiling in Kidney Transplants with Immune Checkpoint Inhibitor-Associated Adverse Events. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 34244334	2021
A Narrative Review of Dietary Approaches for Kidney Transplant Patients. Kidney international reports\| PubMed ID: 34307973	2021
Recurrence of IgA Nephropathy after Kidney Transplantation in Adults. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 34362788	2021
CyTOF-Enabled Analysis Identifies Class-Switched B Cells as the Main Lymphocyte Subset Associated With Disease Relapse in Children With Idiopathic Nephrotic Syndrome. Frontiers in immunology\| PubMed ID: 34621271	2021
Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 34686531	2021
Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. Journal of the American Society of Nephrology : JASN\| PubMed ID: 34732507	2022
Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms. JCI insight\| PubMed ID: 34752418	2021
Corrigendum: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study. Frontiers in immunology\| PubMed ID: 34795679	2021
Mortality in solid organ transplant recipients with COVID-19: More than meets the eye. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 34971486	2022
Kidney immunology: embracing the complexity to advance the field. Clinical kidney journal\| PubMed ID: 35145653	2022
Kidney xenotransplantation in a brain-dead donor: Glass half-full or half-empty? American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 35213783	2022
Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination. Frontiers in immunology\| PubMed ID: 35281011	2022
Xenotransplantation: The Future Is Here. Journal of the American Society of Nephrology : JASN\| PubMed ID: 39626026	2025
T cell depletion increases humoral response by favoring T follicular helper cells expansion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 35320600	2022
Immune Checkpoint Inhibitor Nephrotoxicity: Update 2020. Kidney360\| PubMed ID: 35372904	2020
Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients. Kidney international\| PubMed ID: 35429496	2022
PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nature communications\| PubMed ID: 35449134	2022
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation. Cell reports. Medicine\| PubMed ID: 35492875	2022
Pig-to-human kidney transplantation using brain-dead donors as recipients: One giant leap, or only one small step for transplantkind? Xenotransplantation\| PubMed ID: 35616243	2022
Long-term Apheresis in the Management of Patients With Recurrent Focal Segmental Glomerulosclerosis After Kidney Transplantation. Kidney international reports\| PubMed ID: 35685308	2022
Tixagevimab/cilgavimab pre-exposure prophylaxis is associated with lower breakthrough infection risk in vaccinated solid organ transplant recipients during the omicron wave. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 35727916	2022
Kidney organoids: a pioneering model for kidney diseases. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 35750295	2022
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Frontiers in immunology\| PubMed ID: 35757726	2022
Expert Opinion Special Feature: Patient Selection for Initial Clinical Trials of Pig Organ Transplantation. Transplantation\| PubMed ID: 35761442	2022
Antibody-mediated rejection: prevention, monitoring and treatment dilemmas. Current opinion in organ transplantation\| PubMed ID: 35950887	2022
Factors Associated With Reduced Anti-SARS-CoV-2 Antibody Responses After mRNA Vaccination in Kidney Transplant Recipients on Belatacept. Kidney international reports\| PubMed ID: 35968509	2022
Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation. Cell reports. Medicine\| PubMed ID: 36384101	2022
Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection. Journal of the American Society of Nephrology : JASN\| PubMed ID: 36450597	2022
Desensitization in transplantation: is intravenous immunoglobulin the holy grail? Jornal brasileiro de nefrologia\| PubMed ID: 36524965	2022
Long-term Outcome Reporting in Older Kidney Transplant Recipients and the Limitations of Conventional Survival Metrics. Kidney international reports\| PubMed ID: 36531880	2022
Immune checkpoint inhibitors in kidney transplantation. Current opinion in organ transplantation\| PubMed ID: 36579684	2023
Low-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 36740193	2023
Response to letter entitled: Tixagevimab/cilgavimab pre-exposure prophylaxis and breakthrough infection risk in vaccinated solid organ transplant recipients: Concern for immortal time bias e... American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 36758748	2023
Antibody Responses Against Emerging SARS-CoV-2 Omicron Lineages After the Fourth Dose of mRNA Vaccine in Kidney Transplant Recipients. Transplantation\| PubMed ID: 36978222	2023
Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution. Frontiers in immunology\| PubMed ID: 37063857	2023
Tixagevimab-cilgavimab Preexposure Prophylaxis in Solid Organ Transplant Recipients Is Associated With Fewer Breakthrough SARS-CoV-2 Infections, Except During the BA.5 Period. Transplantation\| PubMed ID: 37271875	2023
Immune abnormalities in IgA nephropathy. Clinical kidney journal\| PubMed ID: 37398689	2023
Inhibitory innate receptors and their potential role in transplantation. Transplantation reviews (Orlando, Fla.)\| PubMed ID: 37451057	2023
Nephrotic-range proteinuria: a potential risk factor for failure of tixagevimab-cilgavimab prophylaxis. Journal of nephrology\| PubMed ID: 37658973	2024
Case report: Successful simultaneous heart-kidney transplantation across a positive complement-dependent cytotoxic crossmatch. Frontiers in nephrology\| PubMed ID: 37675007	2022
The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 37931753	2024
The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 38032300	2024
Chronic Myelomonocytic Leukemia Patients With Lysozyme Nephropathy and Renal Infiltration Display Markers of Severe Disease. Kidney international reports\| PubMed ID: 38106568	2023
Advancing mouse models for transplantation research. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 38219866	2024
Cemiplimab for Kidney Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 38252908	2024
Recurrence of membranous nephropathy after kidney transplantation: A multicenter retrospective cohort study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 38341027	2024
Recurrent C3 glomerulopathy after kidney transplantation. Transplantation reviews (Orlando, Fla.)\| PubMed ID: 38412598	2024
A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models. The Journal of clinical investigation\| PubMed ID: 38426492	2024
Harnessing Immune Cell Metabolism to Modulate Alloresponse in Transplantation. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 38567143	2024
Successful Treatment of Posttransplant Monoclonal Gammopathy-associated C3 Glomerulopathy With Plasma Cell Clone-directed Therapy. Transplantation direct\| PubMed ID: 38606352	2024
Recurrent complement-mediated Hemolytic uremic syndrome after kidney transplantation. Transplantation reviews (Orlando, Fla.)\| PubMed ID: 38749097	2024
Banff 2022 Kidney Commentary: Reflections and Future Directions. Transplantation\| PubMed ID: 38886879	2025
Narrative Review of Immunomodulatory and Anti-inflammatory Effects of Sodium-Glucose Cotransporter 2 Inhibitors: Unveiling Novel Therapeutic Frontiers. Kidney international reports\| PubMed ID: 38899203	2024
The value of pre-transplant coronary angiography findings in kidney transplant candidates at high risk for cardiovascular disease. Frontiers in transplantation\| PubMed ID: 38993884	2023
A pragmatic approach to selective genetic testing in kidney transplant candidates. Frontiers in transplantation\| PubMed ID: 38993907	2023
Clinical characteristics and favorable treatment responses of recurrent focal segmental glomerulosclerosis or steroid-resistant nephrotic syndrome in children after kidney transplantation. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 39001911	2024
Kidney involvement in myelodysplastic syndromes. Clinical kidney journal\| PubMed ID: 39099564	2024
Post-acute Sequelae of COVID-19 Among Solid Organ Transplant Recipients: Insights From the Omicron Period. Transplantation direct\| PubMed ID: 39131235	2024
Two-day Static Cold Preservation of α1,3-Galactosyltransferase Knockout Kidney Grafts Before Simulated Xenotransplantation. Xenotransplantation\| PubMed ID: 39166818	2024
Safety and Efficacy of a Preemptive Mycophenolate Mofetil Dose Reduction Strategy in Kidney Transplant Recipients. Transplantation direct\| PubMed ID: 39220216	2024
The Time Has Come: The Case for Initiating Pilot Clinical Trials of Pig Kidney Xenotransplantation. Annals of surgery\| PubMed ID: 39263749	2024
CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment. EMBO molecular medicine\| PubMed ID: 39271961	2024
Exploring immune response toward transplanted human kidney tissues assembled from organoid building blocks. iScience\| PubMed ID: 39398250	2024
Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice. iScience\| PubMed ID: 39759002	2024
Tacrolimus to belatacept conversion in proteinuric kidney transplant recipients. Frontiers in immunology\| PubMed ID: 39763682	2024
Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance. Transplantation\| PubMed ID: 39800883	2025
The impact of different exercise modalities on chronic kidney disease: an umbrella review of meta-analyses. Frontiers in physiology\| PubMed ID: 39835199	2024
Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease. The New England journal of medicine\| PubMed ID: 39927618	2025
Applying Artificial Intelligence to Quantify Body Composition on Abdominal CTs and Better Predict Kidney Transplantation Wait-List Mortality. Journal of the American College of Radiology : JACR\| PubMed ID: 40044312	2025
Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study. Transplantation direct\| PubMed ID: 40256682	2025
Human type 1 conventional dendritic cells contribute to skin transplant rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 40286910	2025
An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection. Kidney international reports\| PubMed ID: 40303229	2025
Metabolic dysregulation in regulatory T cells from patients with immune-mediated glomerular diseases. Journal of nephrology\| PubMed ID: 40317445	2025
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection. Science translational medicine\| PubMed ID: 40333992	2025
Innate extracellular mouse Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors. Cell stress & chaperones\| PubMed ID: 40412547	2025
Mapping the Evolution of Solid Organ Xenotransplantation Research:A Systematic Review. Xenotransplantation\| PubMed ID: 40551623	2025
Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 40570964	2025
SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation\| PubMed ID: 40702593	2026
PD-L1 on ex-vivo Expanded Toll-like-receptor-Bregs Prevents Allograft Rejection by Breg Viability Promotion, CD4T Effector Cell Suppression, and Tregs Induction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 40925525	2025
Advancements in imaging modalities for post-kidney transplant monitoring: A focus on contrast-enhanced ultrasound. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 40939819	2026
Physiologic Homeostasis in a Living Human after Pig Kidney Xenotransplantation. Nature communications\| PubMed ID: 41006232	2025
Conventional and Contrast-enhanced Ultrasound Imaging in 2 Human Kidney Xenotransplant Recipients. Transplantation\| PubMed ID: 41088519	2025
Beyond theory and into practice: A qualitative study of the experiences of xenotransplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41101596	2026
AI Will Offer New Opportunities for Transplantation: Are We Ready? Transplantation direct\| PubMed ID: 41112059	2025
Erythropoietin prolongs graft survival in mice by counteracting trained immunity. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41135883	2026
Sentinel flaps reflect key inflammatory aspects of human face transplant rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41407105	2025
Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease. Kidney international reports\| PubMed ID: 41426048	2025
Immune profiling in a living human recipient of a gene-edited pig kidney. Nature medicine\| PubMed ID: 41507576	2026
Oral tributyrin supplementation induces regulatory T cell-mediated immune regulation and prolongs allograft survival in preclinical transplant models. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41554342	2026
Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study. Transplantation direct\| PubMed ID: 41567757	2026
Early Experience With Iptacopan for Recurrent IgA Nephropathy After Kidney Transplantation. Kidney medicine\| PubMed ID: 41608295	2026
Move to tolerate: Exercise and environmental factors improve transplant outcomes. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41616978	2026
Clinical Translation of Ultrasound Localization Microscopy: A Narrative Review of Current Applications and Future Directions. Ultrasound in medicine & biology\| PubMed ID: 41651749	2026
Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. Transplantation\| PubMed ID: 41700849	2026