Jianguo Gu

Division of Regulatory Glycobiology, Tohoku Medical and Pharmaceutical University

Affiliated withTohoku Medical and Pharmaceutical University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransfe... The Journal of biological chemistry\| PubMed ID: 19276077	2009
N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. PloS one\| PubMed ID: 22073258	2011
Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation. The Journal of biological chemistry\| PubMed ID: 26483551	2015
Disease-associated glycans on cell surface proteins. Molecular aspects of medicine\| PubMed ID: 27131428	2016
Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27565712	2016
N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4. Scientific reports\| PubMed ID: 27641064	2016
N-Glycoform-dependent interactions of megalin with its ligands. Biochimica et biophysica acta. General subjects\| PubMed ID: 27773703	2017
Specific N-glycan alterations are coupled in epithelial-mesenchymal transition induced by EGF in GE11 epithelial cells. Cell biology international\| PubMed ID: 27888538	2017
Specific N-glycan alterations are coupled in EMT induced by different density cultivation of MCF 10A epithelial cells. Glycoconjugate journal\| PubMed ID: 28035583	2017
A Key Regulator of Cell Adhesion: Identification and Characterization of Important -Glycosylation Sites on Integrin α5 for Cell Migration. Molecular and cellular biology\| PubMed ID: 28167607	2017
Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. Biochimica et biophysica acta. General subjects\| PubMed ID: 28229927	2017
Differential expression of ST6GAL1 in the tumor progression of colorectal cancer. Biochemical and biophysical research communications\| PubMed ID: 28377225	2017
Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure. Carbohydrate polymers\| PubMed ID: 28521993	2017
Roles of Integrin α6β4 Glycosylation in Cancer. Cancers\| PubMed ID: 28678156	2017
Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. Scientific reports\| PubMed ID: 28912543	2017
Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation. Frontiers in immunology\| PubMed ID: 29434598	2018
β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3--Glycan Complex. Molecular cancer research : MCR\| PubMed ID: 29549127	2018
N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30307765	2019
Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation. International journal of molecular sciences\| PubMed ID: 30558169	2018
Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators. Biochimica et biophysica acta. General subjects\| PubMed ID: 30572004	2019
-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes. The Journal of biological chemistry\| PubMed ID: 30587575	2019
Core fucosylation of copper transporter 1 plays a crucial role in cisplatin-resistance of epithelial ovarian cancer by regulating drug uptake. Molecular carcinogenesis\| PubMed ID: 30614075	2019
A complex between phosphatidylinositol 4-kinase IIα and integrin α3β1 is required for -glycan sialylation in cancer cells. The Journal of biological chemistry\| PubMed ID: 30659093	2019
Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut spp. and spp. mBio\| PubMed ID: 30940702	2019
Establishment and characterization of a fucosylated α-fetoprotein-specific monoclonal antibody: a potential application for clinical research. Scientific reports\| PubMed ID: 31451706	2019
EpCAM associates with integrin and regulates cell adhesion in cancer cells. Biochemical and biophysical research communications\| PubMed ID: 31806375	2020
Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation. Biochemical and biophysical research communications\| PubMed ID: 31858971	2020
Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31908039	2020
ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31914669	2020
Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice. The Biochemical journal\| PubMed ID: 32141499	2020
Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi\| PubMed ID: 32146162	2021
Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation. European journal of immunology\| PubMed ID: 32460355	2020
Core Fucosylation of Intestinal Epithelial Cells Protects Against Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota. Frontiers in microbiology\| PubMed ID: 32528455	2020
A novel immunochromatographic strips assay for rapid and simple detection of systemic lupus erythematosus. Scientific reports\| PubMed ID: 32843681	2020
α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma. Biochimica et biophysica acta. General subjects\| PubMed ID: 33571582	2021
O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 34981577	2022
TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6. Cell death & disease\| PubMed ID: 35835740	2022
Integrin β1 in Pancreatic Cancer: Expressions, Functions, and Clinical Implications. Cancers\| PubMed ID: 35884437	2022
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury its anti-inflammation and anti-oxidative stress effects. Frontiers in pharmacology\| PubMed ID: 36120347	2022
The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36252012	2022
α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells\| PubMed ID: 36611938	2022
Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway. The Journal of biological chemistry\| PubMed ID: 36813234	2023
Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells. International journal of molecular sciences\| PubMed ID: 37108200	2023
Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway. The Journal of biological chemistry\| PubMed ID: 37451482	2023
Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2. Biochimica et biophysica acta. General subjects\| PubMed ID: 37748663	2023
A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry\| PubMed ID: 37865317	2023
Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide. The Journal of biological chemistry\| PubMed ID: 38042483	2024
Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit. Biomolecules\| PubMed ID: 38136623	2023
Core fucosylation regulates the ovarian response via FSH receptor during follicular development. Journal of advanced research\| PubMed ID: 38280716	2025
BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia. Cancer science\| PubMed ID: 38288901	2024
Fucosylation inhibitor 6-alkynylfucose enhances the ATRA-induced differentiation effect on acute promyelocytic leukemia cells. Biochemical and biophysical research communications\| PubMed ID: 38608490	2024
An emerging role of N-glycosylation in cancer chemoresistance. Carbohydrate research\| PubMed ID: 38613897	2024
Novel regulatory mechanisms of N-glycan sialylation: Implication of integrin and focal adhesion kinase in the regulation. Biochimica et biophysica acta. General subjects\| PubMed ID: 38614280	2024
The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity. Biochimica et biophysica acta. General subjects\| PubMed ID: 38936637	2024
Specific sialylation of N-glycans and its novel regulatory mechanism. Glycoconjugate journal\| PubMed ID: 38958800	2024
Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose. The Journal of biological chemistry\| PubMed ID: 39002669	2024
The acetylglucosaminyltransferase GnT-Ⅲ regulates erythroid differentiation through ERK/MAPK signaling. The Journal of biological chemistry\| PubMed ID: 39571652	2024
Fucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway. Biochimica et biophysica acta. General subjects\| PubMed ID: 39725242	2025
-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway. Biomolecules\| PubMed ID: 39766284	2024
Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: Implicating core fucosylation has an antidepressant potential. The Journal of biological chemistry\| PubMed ID: 39864626	2025
Inhibitory effects of β-galactoside α2,6-sialyltransferase 1 on the Hippo pathway in breast cancer cells. The Journal of biological chemistry\| PubMed ID: 40409546	2025
Author Correction: A novel immunochromatographic strips assay for rapid and simple detection of systemic lupus erythematosus. Scientific reports\| PubMed ID: 40913035	2025
The role of protein glycosylation in colorectal cancer: From molecular pathways to clinical applications. Biochimica et biophysica acta. Reviews on cancer\| PubMed ID: 40930262	2025
Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions. The Journal of biological chemistry\| PubMed ID: 41461315	2026
Regulation of cancer cell adhesion, progression, and epithelial-to-mesenchymal transition by N-glycosylation. Precision clinical medicine\| PubMed ID: 41668841	2026
ST3GAL3-mediated selective α2,3-sialylation of LDLR promotes vesicular stomatitis virus entry. Biochimica et biophysica acta. General subjects\| PubMed ID: 41734828	2026