impact-different-extraction-methods-on-vitro-bioactivity-profiles

Impact of Different Extraction Methods on the <em>In Vitro</em> Bioactivity Profiles of <em>Terfezia Claveryi</em>

Terfezia claveryi is an edible desert truffle traditionally consumed in arid regions. In recent years, it has attracted increasing scientific interest due ...

Kirsehir Ahi Evran University

This study aimed to determine the content of elemental levels of eight plants species originating from Mauritania and used as medicinal plant and to assess their risk for human health. The range of elemental content in the studied plant parts of these plant species were 0.51-16.1 mg/g for Ca, 2.63-6.49 mg/g for Mg, 11.2-201 μg/g for Al, 6.5-28.2 μg/g for Zn, 5.6-453 μg/g for Fe, 1.1-6.4 μg/g for Ni, 11.0-302 μg/g for Mn and 0.7-9.0 μg/g for Cu. The Cr, Pb, Cd and Co levels were below the limits of detection in all samples. The estimated weekly intake (EWI) and target hazard quotient (THQ) were calculated. Except for Al the THQ values were below 1, so it could be concluded that these plant species have low probability of causing non-cancer health problems for the consumer.

Macro- and trace elements in plants from Mauritania and risk assessment.

The present investigation examined the impact of pomegranate (Punica granatum L.) juice on trace elements, minerals, and oxidative stress in relation to the potential harm inflicted by aluminum chloride (AlCl) in rats. Rats were split into four groups at random for this purpose: control (C), pomegranate juice (PJ), aluminum chloride (A), and PJ + A. For 30 days, PJ was orally administered by gavage at a rate of 4 mL/kg every other day, whereas AlCl was administered intraperitoneally at 8.3 mg/kg. Spectrophotometric analysis was used to measure the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) enzyme activity in various tissues. In addition, high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS) was used to determine the amounts of the elements Al, Cu, Fe, Mn, Zn, Ca, and Mg in the tissues. It was discovered that when PJ therapy was applied to all tissues, the antioxidant enzymes SOD and CAT activity increased, the GSH level rose, and the MDA level, a sign of lipid peroxidation, decreased. Al and Ca levels increased in the A group relative to the C group in all tissues, whereas they decreased in the A + PJ group relative to the A group. Group A exhibited a proportionate increase in Fe levels in the liver and renal tissues compared with group C. Furthermore, the A group's brain tissue had a higher Fe level than the C group's. The A + PJ group's brain tissue had a lower Fe level than the A group's. Our findings demonstrate that PJ therapy greatly decreased Al buildup and oxidative stress in tissues while controlling variations in trace element levels. In addition, it is concluded that PJ might have value as a strong chelating agent to prevent Al poisoning.

Alleviation of Aluminum-Induced Oxidative Stress, Trace Element, and Mineral Levels in Rat Tissues Protective Role of Pomegranate Juice (Punica Granatum L.).

Cardiovascular diseases are significant health problems that cause high mortality rates worldwide. Myocardial infarction (MI), in particular, is one of the leading conditions among these diseases. The aim of this study is to evaluate the potential therapeutic approach of carvacrol in the treatment of cardiovascular diseases by investigating its protective effects against myocardial infarction through oxidative stress and biomarker levels.

Article	Year
Macro- and trace elements in plants from Mauritania and risk assessment. Food additives & contaminants. Part B, Surveillance\| PubMed ID: 37746844	2023
Alleviation of Aluminum-Induced Oxidative Stress, Trace Element, and Mineral Levels in Rat Tissues Protective Role of Pomegranate Juice (Punica Granatum L.). Biological trace element research\| PubMed ID: 38097903	2024
Cardioprotective effects of carvacrol in the isoproterenol-induced myocardial infarction model. BMC pharmacology & toxicology\| PubMed ID: 40660388	2025

Kubra Ozturk

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