efficacy-safety-intra-articular-sodium-hyaluronate-for-ankle-involved

Efficacy and Safety of Intra-articular Sodium Hyaluronate for Ankle-involved Kashin-Beck Disease: A 12-month Prospective Self-controlled Study

This study aimed to evaluate the efficacy and safety of intra-articular sodium hyaluronate injection over a 12-month follow-up period in patients with ...

Xi'an Jiaotong University Health Science Center

Kashin-Beck disease (KBD) in western China is not well controlled. The objective of this study is to evaluate prevention and control children with KBD through a meta-analysis of a community-based trial. Web of knowledge, PubMed, Elsevier, the Chinese National Knowledge Infrastructure (CNKI), VIP and Wanfang data had been electronically searched up to February 2015. Search terms included the trial terms "Salt rich selenium" and "Kashin-Beck disease." Eligible studies were prospective trials of salt-rich selenium in endemic villages. Data extraction was performed by two authors using predefined data fields that also included quality evaluation. Of 292 potentially relevant articles initially screened, reporting 11 community-based trials with a total enrollment of 2652 participants were included, from five provinces in China. The pooled odds ratios (OR) and 95 % confidence intervals (CI) of primary prevention in healthy children were 0.16 and 0.08∼0.33, respectively. The OR and 95 % CI of clinical improvement in KBD children were 6.57 and 3.33∼12.93, respectively. The OR of repairing rate of metaphysis lesions was 5.53 (95 % CI 2.92∼10.47) based on X-ray film, which was statistically significantly different in favor of salt-rich selenium. The combined standard mean difference (SMD) of selenium content in hair was 2.54 (95 % CI 1.21∼3.87) which was significantly higher in selenium group. Current evidence showed that supplement salt-rich selenium was effective in reducing new incidence in healthy children and clinical improvement including repairing metaphysis lesions instead of repairing distal end of phalanx lesions in KBD children.

Salt-Rich Selenium for Prevention and Control Children with Kashin-Beck Disease: a Meta-analysis of Community-Based Trial.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Kashin-Beck disease (KBD) remains a significant public health challenge in northwestern China, where chronic joint pain and functional limitations severely compromise quality of life (QoL). Despite growing recognition of sex-related disparities in musculoskeletal conditions, sex-specific differences in pain, limb function, and QoL among KBD patients remain underexplored. This study aimed to investigate these disparities to enhance understanding and guide tailored management.

Article	Year
Salt-Rich Selenium for Prevention and Control Children with Kashin-Beck Disease: a Meta-analysis of Community-Based Trial. Biological trace element research\| PubMed ID: 26198135	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Sex differences in joint pain, limb function and quality of life among patients with Kashin-Beck disease in Northwest China. BMC musculoskeletal disorders\| PubMed ID: 41257713	2025

Hua Fang

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