molecular-mechanisms-dachengqi-decoction-acute-respiratory-distress

Molecular Mechanisms of Dachengqi Decoction in Acute Respiratory Distress Syndrome: A Network Pharmacology and Bioinformatics Analysis

Acute respiratory distress syndrome (ARDS) is a life-threatening complication of sepsis, characterized by refractory hypoxemia and pulmonary inflammation. ...

The Fourth Affiliated Hospital of Soochow University

Hyperthyroidism is linked to several muscle disorders, including thyrotoxic myopathy, myasthenia gravis, and periodic paralysis. Thyrotoxic periodic paralysis (TPP) is a rare and potentially life-threatening neuromuscular condition that predominantly affects Asian males and is characterized by muscle weakness, hypokalemia, and thyrotoxicosis. Treatment involves potassium supplementation, and beta-blockers. In rare cases, recurrent muscle weakness episodes can impact the respiratory muscles, potentially leading to acute respiratory failure. This case represents the first documented instance of TPP associated with multiple hypoxemia episodes.

Thyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review.

Sepsis, a complex clinical syndrome, is characterized by the body's excessive response to infection, which triggers systemic inflammation. The lungs are the most vulnerable organs in patients with this disease, leading to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) as common complications of sepsis. These complications significantly increase the risk of death for patients, profoundly affect their prognosis, and impose significant burdens on public health. Posttranslational modifications (PTMs) of proteins play a critical role in regulating protein solubility, activity, stability, and mediating protein-protein interactions. Any changes in homeostasis in the body can affect cellular function by altering PTMs, thereby promoting the development of ALI/ARDS. This review focuses on several validated PTMs and explores their specific mechanisms of action in sepsis-induced ALI/ARDS. We hope to provide novel insights for understanding the occurrence and development of the disease by summarizing existing research results and to provide a theoretical basis for the formulation of diagnosis and treatment strategies. Furthermore, future research directions will be discussed with the goal of advancing targeted therapies against PTMs to enhance clinical outcomes for patients suffering from sepsis.

Article	Year
Thyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review. Radiology case reports\| PubMed ID: 39845278	2025
Implications of Protein Posttranslational Modifications in Sepsis-Induced Acute Lung Injury and Acute Respiratory Distress Syndrome. Shock (Augusta, Ga.)\| PubMed ID: 40267484	2025

Da Gu

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