Don D. Sin

Centre for Heart Lung Innovation, University of British Columbia

Affiliated withUniversity of British Columbia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology\| PubMed ID: 25514360	2015
Serum Bilirubin and Disease Progression in Mild COPD. Chest\| PubMed ID: 25539285	2015
Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 25945594	2015
Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases. American journal of respiratory cell and molecular biology\| PubMed ID: 26102239	2016
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. The Lancet. Respiratory medicine\| PubMed ID: 26404118	2015
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature communications\| PubMed ID: 26635082	2015
Impact of individualized care on readmissions after a hospitalization for acute exacerbation of COPD. International journal of chronic obstructive pulmonary disease\| PubMed ID: 26792986	2016
The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco\| PubMed ID: 27154971	2016
A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation. PloS one\| PubMed ID: 27434033	2016
Individualized prediction of lung-function decline in chronic obstructive pulmonary disease. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 27486205	2016
COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry. PloS one\| PubMed ID: 27525416	2016
A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 27658890	2016
Sex-Related Differences in Pulmonary Function following 6 Months of Cigarette Exposure: Implications for Sexual Dimorphism in Mild COPD. PloS one\| PubMed ID: 27788167	2016
The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus. BMC pulmonary medicine\| PubMed ID: 27829448	2016
Findings on Thoracic Computed Tomography Scans and Respiratory Outcomes in Persons with and without Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study. PloS one\| PubMed ID: 27861566	2016
Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection. PloS one\| PubMed ID: 27902753	2016
Recurrent pneumothorax related to diffuse dendriform pulmonary ossification in genetically predisposed individual. Respirology case reports\| PubMed ID: 27999676	2017
Enumerateblood - an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles. BMC genomics\| PubMed ID: 28061752	2017
Asthma-COPD Overlap Syndrome: What We Know and What We Don't. Tuberculosis and respiratory diseases\| PubMed ID: 28119742	2017
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature genetics\| PubMed ID: 28166213	2017
Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy. International journal of chronic obstructive pulmonary disease\| PubMed ID: 28203068	2017
Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion. Aging\| PubMed ID: 28237978	2017
C-reactive protein and N-terminal prohormone brain natriuretic peptide as biomarkers in acute exacerbations of COPD leading to hospitalizations. PloS one\| PubMed ID: 28328968	2017
Impact of a COPD comprehensive case management program on hospital length of stay and readmission rates. International journal of chronic obstructive pulmonary disease\| PubMed ID: 28356728	2017
Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease. Respiratory research\| PubMed ID: 28438154	2017
Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers. American journal of respiratory cell and molecular biology\| PubMed ID: 28459279	2017
Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease. EBioMedicine\| PubMed ID: 28461224	2017
Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori. Respiratory research\| PubMed ID: 28558695	2017
American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report. American journal of respiratory and critical care medicine\| PubMed ID: 28636425	2017
Survival of Lung Transplant Candidates With COPD: BODE Score Reconsidered. Chest\| PubMed ID: 29054348	2018
Serum bilirubin and the risk of chronic obstructive pulmonary disease exacerbations. Respiratory research\| PubMed ID: 29065885	2017
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine\| PubMed ID: 29066090	2017
Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation. The European respiratory journal\| PubMed ID: 29191953	2017
Phenotyping COPD exacerbations using imaging and blood-based biomarkers. International journal of chronic obstructive pulmonary disease\| PubMed ID: 29386890	2018
Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respiratory research\| PubMed ID: 29415723	2018
Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD. Respiratory research\| PubMed ID: 29444682	2018
Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease. BMC medicine\| PubMed ID: 29495970	2018
Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort. Respiratory research\| PubMed ID: 29499758	2018
Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations. Human molecular genetics\| PubMed ID: 29547942	2018
The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis. Journal of general internal medicine\| PubMed ID: 29611088	2018
The genetics of smoking in individuals with chronic obstructive pulmonary disease. Respiratory research\| PubMed ID: 29631575	2018
Emergency department management of acute exacerbations of chronic obstructive pulmonary disease: factors predicting readmission. International journal of chronic obstructive pulmonary disease\| PubMed ID: 29872284	2018
Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV). Respiratory research\| PubMed ID: 29895291	2018
Severity of Airflow Obstruction and Work Loss in a Nationwide Population of Working Age. Scientific reports\| PubMed ID: 29946117	2018
Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease. Respiratory research\| PubMed ID: 30001715	2018
Decreased microbiome diversity in the HIV small airway epithelium. Respiratory research\| PubMed ID: 30053882	2018
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nature communications\| PubMed ID: 30061609	2018
The diagnostic performance of patient symptoms in screening for COPD. Respiratory research\| PubMed ID: 30075717	2018
The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD. Scientific reports\| PubMed ID: 30089872	2018
Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome open research\| PubMed ID: 30175238	2018
What are the long-term effects of smoked marijuana on lung health? CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 30348738	2018
Ectopic adiposity and cardiometabolic health in COPD. International journal of chronic obstructive pulmonary disease\| PubMed ID: 30410322	2018
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine\| PubMed ID: 30552067	2019
Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples. International journal of chronic obstructive pulmonary disease\| PubMed ID: 30774328	2019
Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 30786740	2019
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature genetics\| PubMed ID: 30804560	2019
Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study. Chest\| PubMed ID: 31150638	2019
IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis. The European respiratory journal\| PubMed ID: 31196943	2019
Karma of Cardiovascular Disease Risk Factors for Prevention and Management of Major Cardiovascular Events in the Context of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Frontiers in cardiovascular medicine\| PubMed ID: 31294030	2019
Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial. Respiratory research\| PubMed ID: 31382977	2019
Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada. International journal of chronic obstructive pulmonary disease\| PubMed ID: 31564848	2019
BMI is associated with FEV decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials. Respiratory research\| PubMed ID: 31665000	2019
Diet and COPD: Are we what we eat? EClinicalMedicine\| PubMed ID: 31709393	2019
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. American journal of respiratory and critical care medicine\| PubMed ID: 31710517	2020
Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking. Scientific reports\| PubMed ID: 31772224	2019
Sex differences in lymphoid follicles in COPD airways. Respiratory research\| PubMed ID: 32033623	2020
Effects of sex and chronic cigarette smoke exposure on the mouse cecal microbiome. PloS one\| PubMed ID: 32251484	2020
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. The European respiratory journal\| PubMed ID: 32269089	2020
COVID-19 and nicotine as a mediator of ACE-2. The European respiratory journal\| PubMed ID: 32350104	2020
Reply to: "Current smoking is not associated with COVID-19". The European respiratory journal\| PubMed ID: 32366490	2020
SARS-CoV-2 receptor ACE2 gene expression and RAAS inhibitors. The Lancet. Respiratory medicine\| PubMed ID: 32411576	2020
Smoking, ACE-2 and COVID-19: ongoing controversies. The European respiratory journal\| PubMed ID: 32430431	2020
Association between COPD exacerbations and lung function decline during maintenance therapy. Thorax\| PubMed ID: 32532852	2020
Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19? American journal of respiratory and critical care medicine\| PubMed ID: 32687386	2020
Biomarkers in Chronic Obstructive Pulmonary Disease: The Gateway to Precision Medicine. Clinics in chest medicine\| PubMed ID: 32800193	2020
COVID-19 and COPD. The European respiratory journal\| PubMed ID: 32817205	2020
The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline. International journal of chronic obstructive pulmonary disease\| PubMed ID: 32821093	2020
Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study. Thorax\| PubMed ID: 32839289	2020
Simulation of nanoparticle transport and adsorption in a microfluidic lung-on-a-chip device. Biomicrofluidics\| PubMed ID: 32849976	2020
Should the number of acute exacerbations in the previous year be used to guide treatments in COPD? The European respiratory journal\| PubMed ID: 32855228	2021
Sex differences between women and men with COPD: A new analysis of the 3CIA study. Respiratory medicine\| PubMed ID: 32858497	2020
Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral Therapy. The Journal of infectious diseases\| PubMed ID: 32959881	2021
COVID-19 in COPD: A growing concern. EClinicalMedicine\| PubMed ID: 32984790	2020
Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). Biomedicines\| PubMed ID: 33050042	2020
The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease. Tuberculosis and respiratory diseases\| PubMed ID: 33076634	2020
Association of surfactant protein D with pulmonary metastases from colon cancer. Oncology letters\| PubMed ID: 33123238	2020
Cost Effectiveness of Case Detection Strategies for the Early Detection of COPD. Applied health economics and health policy\| PubMed ID: 33135094	2021
Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data. ERJ open research\| PubMed ID: 33263033	2020
High eosinophil counts predict decline in FEV: results from the CanCOLD study. The European respiratory journal\| PubMed ID: 33303555	2021
Gene expression network analysis provides potential targets against SARS-CoV-2. Scientific reports\| PubMed ID: 33318519	2020
Towards large-scale case-finding: training and validation of residual networks for detection of chronic obstructive pulmonary disease using low-dose CT. The Lancet. Digital health\| PubMed ID: 33328058	2020
Beta-blockers in chronic obstructive pulmonary disease: the good, the bad and the ugly. Current opinion in pulmonary medicine\| PubMed ID: 33332878	2021
ACE inhibition and cardiometabolic risk factors, lung and gene expression, and plasma ACE2 levels: a Mendelian randomization study. Royal Society open science\| PubMed ID: 33391794	2020
DNA methylation is associated with airflow obstruction in patients living with HIV. Thorax\| PubMed ID: 33443234	2021
Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis. Respiratory research\| PubMed ID: 33602241	2021
The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Stu... International journal of chronic obstructive pulmonary disease\| PubMed ID: 33603357	2021
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19. Human genetics\| PubMed ID: 33604698	2021
Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 33605487	2021
Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea. Therapeutic advances in chronic disease\| PubMed ID: 33613934	2021
Mild catalytic defects of tert rs61748181 polymorphism affect the clinical presentation of chronic obstructive pulmonary disease. Scientific reports\| PubMed ID: 33619289	2021
Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells. Respiratory research\| PubMed ID: 33622325	2021
Pulmonary Rehabilitation in a Post-COVID-19 World: Telerehabilitation as a New Standard in Patients with COPD. International journal of chronic obstructive pulmonary disease\| PubMed ID: 33642858	2021
IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma. Respiratory research\| PubMed ID: 33653328	2021
Microchip RT-PCR Detection of Nasopharyngeal SARS-CoV-2 Samples. The Journal of molecular diagnostics : JMD\| PubMed ID: 33706009	2021
Variants associated with expression have sex-differential effects on lung function. Wellcome open research\| PubMed ID: 33728380	2020
COPD and the risk of poor outcomes in COVID-19: A systematic review and meta-analysis. EClinicalMedicine\| PubMed ID: 33758801	2021
Clotting in COVID-19: Is It All in the Genes? American journal of respiratory cell and molecular biology\| PubMed ID: 33784208	2021
Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial. The European respiratory journal\| PubMed ID: 33795322	2021
Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures. Scientific reports\| PubMed ID: 33859282	2021
Dyspnoea and symptom burden in mild-moderate COPD: the Canadian Cohort Obstructive Lung Disease Study. ERJ open research\| PubMed ID: 33898621	2021
IgG Levels and Mortality in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 33945775	2021
Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia. Canadian journal of physiology and pharmacology\| PubMed ID: 33951396	2021
SARS-CoV-2 rapid antigen testing for departing passengers at Vancouver International Airport. Journal of travel medicine\| PubMed ID: 34046663	2021
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank. Communications biology\| PubMed ID: 34103634	2021
FAM13A as potential therapeutic target in modulating TGF-β-induced airway tissue remodeling in COPD. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 34105356	2021
Methylxanthines in COPD: yes to caffeine, no to theophylline. The European respiratory journal\| PubMed ID: 34112714	2021
Update on Asthma-COPD Overlap (ACO): A Narrative Review. International journal of chronic obstructive pulmonary disease\| PubMed ID: 34168440	2021
A mechanical test of the tenertaxis hypothesis for leukocyte diapedesis. The European physical journal. E, Soft matter\| PubMed ID: 34236552	2021
The impact of lockdown timing on COVID-19 transmission across US counties. EClinicalMedicine\| PubMed ID: 34308301	2021
Effects of Inhaled Corticosteroid/Long-Acting β-Agonist Combination on the Airway Microbiome of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial (D... American journal of respiratory and critical care medicine\| PubMed ID: 34464242	2021
Disease activity in COPD: time to make imaging biomarkers a PET project? ERJ open research\| PubMed ID: 34476244	2021
Moving beyond AUC: decision curve analysis for quantifying net benefit of risk prediction models. The European respiratory journal\| PubMed ID: 34503984	2021
Correction to: A mechanical test of the tenertaxis hypothesis forleukocyte diapedesis. The European physical journal. E, Soft matter\| PubMed ID: 34519902	2021
Epigenetic blood biomarkers of ageing and mortality in COPD. The European respiratory journal\| PubMed ID: 34561282	2021
Altered Polarization and Impaired Phagocytic Activity of Lung Macrophages in People With Human Immunodeficiency Virus and Chronic Obstructive Pulmonary Disease. The Journal of infectious diseases\| PubMed ID: 34610114	2022
Radiofrequency therapy improves exercise capacity of mice with emphysema. Scientific reports\| PubMed ID: 34625605	2021
Asthma-COPD Overlap: What Are the Important Questions? Chest\| PubMed ID: 34626594	2022
The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD. The European respiratory journal\| PubMed ID: 34675046	2022
Pulmonary rehabilitation in a postcoronavirus disease 2019 world: feasibility, challenges, and solutions. Current opinion in pulmonary medicine\| PubMed ID: 34690256	2022
Computed tomography total airway count predicts progression to COPD in at-risk smokers. ERJ open research\| PubMed ID: 34708120	2021
Airway luminal area and the resistive work of breathing during exercise in healthy young females and males. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 34709072	2021
Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 34739356	2022
Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease. Thorax\| PubMed ID: 34836921	2022
Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease. Respiratory research\| PubMed ID: 34937547	2021
Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation. Orphanet journal of rare diseases\| PubMed ID: 35012599	2022
The Role of the Dynamic Lung Extracellular Matrix Environment on Fibroblast Morphology and Inflammation. Cells\| PubMed ID: 35053300	2022
Genetic Associations and Architecture of Asthma-COPD Overlap. Chest\| PubMed ID: 35104449	2022
Distinct bronchial microbiome precedes clinical diagnosis of lung cancer. Molecular cancer\| PubMed ID: 35255902	2022
The Hidden and Unchecked Judgement Calls When Using Exacerbation History for Managing COPD. Archivos de bronconeumologia\| PubMed ID: 35312573	2022
Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study. American journal of respiratory and critical care medicine\| PubMed ID: 35380941	2022
Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 35426765	2022
GETting to know the many causes and faces of COPD. The Lancet. Respiratory medicine\| PubMed ID: 35427529	2022
Software development to optimize the minimal detectable difference in human airway images captured using optical coherence tomography. Clinical physiology and functional imaging\| PubMed ID: 35522086	2022
Cigarette Smoking and Asthma. The journal of allergy and clinical immunology. In practice\| PubMed ID: 35533997	2022
Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease. Biomedicines\| PubMed ID: 35625847	2022
The impact of IgG subclass deficiency on the risk of mortality in hospitalized patients with COPD. Respiratory research\| PubMed ID: 35641962	2022
Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies. Respiratory research\| PubMed ID: 35715807	2022
Airway Eosinophilia on Bronchoalveolar Lavage and the Risk of Exacerbations in COPD. Biomedicines\| PubMed ID: 35740433	2022
ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exacerbation prediction tool (ACCEPT). EClinicalMedicine\| PubMed ID: 35898315	2022
Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision. American journal of respiratory and critical care medicine\| PubMed ID: 35914087	2022
The relationship between the epigenetic aging biomarker "grimage" and lung function in both the airway and blood of people living with HIV: An observational cohort study. EBioMedicine\| PubMed ID: 35944348	2022
Pharmacotherapy considerations for morning symptoms in chronic obstructive pulmonary disease. Expert opinion on pharmacotherapy\| PubMed ID: 35986503	2022
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response. Clinical and translational allergy\| PubMed ID: 36036237	2022
RETHINCking COPD - Bronchodilators for Symptomatic Tobacco-Exposed Persons with Preserved Lung Function? The New England journal of medicine\| PubMed ID: 36066080	2022
Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission. Lancet (London, England)\| PubMed ID: 36075255	2022
Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review and meta-analysis. The European respiratory journal\| PubMed ID: 36137586	2023
Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties. Vascular pharmacology\| PubMed ID: 36179789	2022
Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets. Respiratory research\| PubMed ID: 36217144	2022
Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma. Cells\| PubMed ID: 36230980	2022
Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes. Frontiers in immunology\| PubMed ID: 36451808	2022
Common Respiratory Pathogens Other Than in Small Airways are Associated With Neutrophilic Inflammation and Poor Health Status in Stable COPD Patients. Chronic obstructive pulmonary diseases (Miami, Fla.)\| PubMed ID: 36459695	2023
Generalizability of Risk Stratification Algorithms for Exacerbations in COPD. Chest\| PubMed ID: 36509123	2023
Reply: Association between triple therapy and major adverse cardiovascular events in COPD patients. The European respiratory journal\| PubMed ID: 36549713	2023
The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging. Biomedicines\| PubMed ID: 36551848	2022
Physical Activity and Symptom Burden in COPD: The Canadian Obstructive Lung Disease Study. Chronic obstructive pulmonary diseases (Miami, Fla.)\| PubMed ID: 36563057	2023
The : the ERS flagship heads for the next frontier. The European respiratory journal\| PubMed ID: 36634923	2023
Is long COVID an autoimmune disease? The European respiratory journal\| PubMed ID: 36634924	2023
Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPD. Biomedicines\| PubMed ID: 36672643	2023
IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized impact study. Diagnostic and prognostic research\| PubMed ID: 36782301	2023
measurements of lung function using respiratory-gated micro-computed tomography in a smoke-exposure model of chronic obstructive pulmonary disease. Journal of medical imaging (Bellingham, Wash.)\| PubMed ID: 36818545	2023
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. American journal of respiratory and critical care medicine\| PubMed ID: 36856433	2023
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Respirology (Carlton, Vic.)\| PubMed ID: 36856440	2023
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. The European respiratory journal\| PubMed ID: 36858443	2023
Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study. Chest\| PubMed ID: 36871842	2023
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Archivos de bronconeumologia\| PubMed ID: 36933949	2023
Air pollution and COPD: GOLD 2023 committee report. The European respiratory journal\| PubMed ID: 36958741	2023
Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community. Biomedicines\| PubMed ID: 36979819	2023
The Importance of Early Chronic Obstructive Pulmonary Disease: A Lecture from 2022 Asian Pacific Society of Respirology. Tuberculosis and respiratory diseases\| PubMed ID: 37005090	2023
Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know. Tuberculosis and respiratory diseases\| PubMed ID: 37038880	2023
Age-associated differences in the human lung extracellular matrix. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 37039368	2023
The need to streamline approval processes for clinical research in Canada. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 37040997	2023
Factors Associated with Attrition in a Longitudinal Cohort of Older Adults in the Community. Chronic obstructive pulmonary diseases (Miami, Fla.)\| PubMed ID: 37099700	2023
Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi'omics profiling. Respiratory research\| PubMed ID: 37143066	2023
Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort. Thorax\| PubMed ID: 37147124	2023
GOLD COPD DOCUMENT 2023: a brief update for practicing cardiologists. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 37233751	2024
Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations. American journal of respiratory and critical care medicine\| PubMed ID: 37286295	2023
The GOLD 2023 proposed taxonomy: a new tool to determine COPD etiotypes. The European respiratory journal\| PubMed ID: 37290808	2023
An integrated cell atlas of the lung in health and disease. Nature medicine\| PubMed ID: 37291214	2023
Quantifying COPD as a risk factor for cardiac disease in a primary prevention cohort. The European respiratory journal\| PubMed ID: 37385658	2023
Predicting steroid responsiveness using airway smooth muscle in COPD: a HISTORIC study. The European respiratory journal\| PubMed ID: 37474151	2023
Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis. European respiratory review : an official journal of the European Respiratory Society\| PubMed ID: 37558261	2023
Phenotypes, Etiotypes, and Endotypes of Exacerbations of Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 37560988	2023
2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD. Chest\| PubMed ID: 37690008	2023
Trends in hospital admissions for chronic obstructive pulmonary disease over 16 years in Canada. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 37696554	2023
NLR in CBC: A holy grail for biomarker research in COPD? Respirology (Carlton, Vic.)\| PubMed ID: 37696582	2023
A Cost-Effectiveness Analysis of Azithromycin for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society\| PubMed ID: 37703432	2023
Development of a unilateral porcine emphysema model induced by porcine pancreatic elastase. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 37767558	2023
Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol. BioTechniques\| PubMed ID: 37815826	2023
Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema. American journal of respiratory and critical care medicine\| PubMed ID: 37917913	2024
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase. Nature communications\| PubMed ID: 37963864	2023
QRISK3 underestimates the risk of cardiovascular events in patients with COPD. Thorax\| PubMed ID: 38050168	2024
Genome-wide association study of preserved ratio impaired spirometry (PRISm). The European respiratory journal\| PubMed ID: 38097206	2024
Single-Cell Sequencing of Lung Macrophages and Monocytes Reveals Novel Therapeutic Targets in COPD. Cells\| PubMed ID: 38132091	2023
2024: your journal, my journal, our journal. The European respiratory journal\| PubMed ID: 38176701	2024
Heightened long-term cardiovascular risks after exacerbation of chronic obstructive pulmonary disease. Heart (British Cardiac Society)\| PubMed ID: 38182279	2024
Mild airways obstruction: spirometric diagnostic pitfalls and solutions. Current opinion in pulmonary medicine\| PubMed ID: 38265250	2024
Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD. COPD\| PubMed ID: 38314671	2024
Cluster Analysis to Identify Long COVID Phenotypes Using Xe Magnetic Resonance Imaging: A Multi-centre Evaluation. The European respiratory journal\| PubMed ID: 38331459	2024
What Single Cell RNA Sequencing Has Taught Us about Chronic Obstructive Pulmonary Disease. Tuberculosis and respiratory diseases\| PubMed ID: 38369875	2024
A Proposed Approach to Pulmonary Long COVID: A Viewpoint. The European respiratory journal\| PubMed ID: 38453258	2024
Type 2 airway inflammation in chronic obstructive pulmonary disease. The European respiratory journal\| PubMed ID: 38485148	2024
Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions. Advanced healthcare materials\| PubMed ID: 38563726	2024
Why Is BMI Related to COPD? Is It All in the Genes? American journal of respiratory and critical care medicine\| PubMed ID: 38593419	2024
Cannabis smoking is associated with advanced epigenetic age. The European respiratory journal\| PubMed ID: 38609099	2024
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease. Expert review of molecular diagnostics\| PubMed ID: 38635513	2024
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature genetics\| PubMed ID: 38641645	2024
Leveraging Computed Tomography Imaging to Detect Chronic Obstructive Pulmonary Disease and Concomitant Chronic Diseases. American journal of respiratory and critical care medicine\| PubMed ID: 38843079	2024
DNA Methylation Demonstrates Bronchoalveolar Cell Senescence in People Living with HIV: An Observational Cohort Study. Biomedicines\| PubMed ID: 38927468	2024
Global Initiative for Chronic Obstructive Lung Disease and Canadian Thoracic Society COPD Guidelines: Two Sides of the Same Coin or Different Coins? Chest\| PubMed ID: 38986638	2024
Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosis. medRxiv : the preprint server for health sciences\| PubMed ID: 39040187	2024
Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal rep... Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 39147560	2024
What Harm Are We Doing to Our Patients with Asthma by Using High-Dose Inhaled Corticosteroids? American journal of respiratory and critical care medicine\| PubMed ID: 39226124	2025
Hypoxia inducible factor (HIF) 3α prevents COPD by inhibiting alveolar epithelial cell ferroptosis via the HIF-3α-GPx4 axis. Theranostics\| PubMed ID: 39310101	2024
Single-cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID. The European respiratory journal\| PubMed ID: 39326914	2024
Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. Nature communications\| PubMed ID: 39366959	2024
Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation. iScience\| PubMed ID: 39391738	2024
Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies. EBioMedicine\| PubMed ID: 39509750	2024
Best in Class: IgG as a Treatable Trait for Exacerbation Prevention in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 39556414	2025
Food for thought: optimal diet in patients with asthma and chronic obstructive pulmonary disease. Current opinion in pulmonary medicine\| PubMed ID: 39607023	2025
A new era in the treatment of acute exacerbations of asthma and COPD. The Lancet. Respiratory medicine\| PubMed ID: 39615501	2025
SMART: spatial transcriptomics deconvolution using marker-gene-assisted topic model. Genome biology\| PubMed ID: 39623485	2024
GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD. The European respiratory journal\| PubMed ID: 39638416	2025
Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis. HGG advances\| PubMed ID: 39876559	2025
The : our drive to thrive in '25! The European respiratory journal\| PubMed ID: 39884752	2025
Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response. The European respiratory journal\| PubMed ID: 39978857	2025
Impact of COPD on cardiovascular risk factors and outcomes in people with established cardiovascular disease. Thorax\| PubMed ID: 40032508	2025
The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study. BMJ open\| PubMed ID: 40050062	2025
Climate Change and Chronic Obstructive Pulmonary Disease: A GOLD Science Committee Review. American journal of respiratory and critical care medicine\| PubMed ID: 40072246	2025
COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era. International journal of chronic obstructive pulmonary disease\| PubMed ID: 40125072	2025
Make it count with photon-counting computed tomography: a revolution in technology for investigating the airways. The European respiratory journal\| PubMed ID: 40180355	2025
COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 40192657	2025
Should all patients with COPD be treated with inhaled triple therapy? ERJ open research\| PubMed ID: 40196716	2025
Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation. BMC pulmonary medicine\| PubMed ID: 40205553	2025
How Should We Treat COPD Exacerbations in the Future? By Endophenotyping, Of Course! Archivos de bronconeumologia\| PubMed ID: 40221276	2025
A tale as old as time - the importance of accelerated lung aging in chronic obstructive pulmonary disease. Expert review of respiratory medicine\| PubMed ID: 40222750	2025
Asthma coexistence does not worsen or accelerate the decline in exercise capacity in COPD. ERJ open research\| PubMed ID: 40297652	2025
Social Determinants of Health and Racial Disparities in Lung Function: Findings from the National Health and Nutrition Examination Survey, 2007-2012. American journal of respiratory and critical care medicine\| PubMed ID: 40343923	2025
Loss of Lung Function Led to Loss of Life during the COVID-19 Pandemic. American journal of respiratory and critical care medicine\| PubMed ID: 40377663	2025
Integration of mass cytometry and single-cell RNA-sequencing of cells in bronchoalveolar lavage. BioTechniques\| PubMed ID: 40384395	2025
Brownian dynamics simulation of the diffusion of rod-like nanoparticles in polymeric gels. Soft matter\| PubMed ID: 40539637	2025
Utility of diaphragm dome height as a marker of operational lung volume changes, disease burden and exacerbations in patients with mild-to-moderate COPD: an observational study within the Ca... ERJ open research\| PubMed ID: 40589904	2025
Exploring Multi-Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far. Biotechnology and bioengineering\| PubMed ID: 40726012	2025
Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium. Carcinogenesis\| PubMed ID: 40746155	2025
Hyperpolarized Xe MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities. Radiology. Cardiothoracic imaging\| PubMed ID: 40772846	2025
Trends and Regional Differences in the Use of Maintenance Inhaled Medications in COPD: A Population-Based Study. Journal of general internal medicine\| PubMed ID: 40775112	2026
Airway epithelial SARS-CoV-2 infectious and repair responses: relationships to age, sex, and post-COVID pulmonary syndromes. bioRxiv : the preprint server for biology\| PubMed ID: 40791384	2025
A person-centred clinical approach to the multimorbid patient with COPD. European journal of internal medicine\| PubMed ID: 40803921	2025
Molecular Determinants of Lung Function Decline: A Multi- Level Analysis of Gene Expression. Research square\| PubMed ID: 40894069	2025
Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms. Frontiers in medicine\| PubMed ID: 40901507	2025
Absolute benefit measures are essential for guiding therapies in COPD in an era of precision medicine: a viewpoint on "number needed to treat". The European respiratory journal\| PubMed ID: 40935585	2025
Pollution-induced ITIH4 deficiency: a gateway to novel targeted antioxidant therapy in COPD? The European respiratory journal\| PubMed ID: 40962424	2025
The Developmental Origins of Asthma and COPD. Annual review of physiology\| PubMed ID: 40967241	2026
Reply to: Decoding the eosinophil connection: implications for precision treatment of emphysematous in COPD. The European respiratory journal\| PubMed ID: 41057217	2025
Discrepancies between observed and self-identified race in spirometry interpretation: insights from the Canadian Longitudinal Study on Aging. The European respiratory journal\| PubMed ID: 41151989	2025
Clinically important deterioration in a mild-moderate COPD population. ERJ open research\| PubMed ID: 41179110	2025
Healthcare resource utilisation in patients with exacerbations of COPD and associated cardiovascular events: the EXACOS-CV study. ERJ open research\| PubMed ID: 41189578	2025
Clinical, physiological, imaging and molecular responses to cannabis smoking: the Canadian Users of Cannabis Smoke (CANUCK) study. The European respiratory journal\| PubMed ID: 41198398	2026
A novel treatment for emphysema in a porcine model: extracorporeal radiofrequency. ERJ open research\| PubMed ID: 41257189	2025
Molecular determinants of lung function decline: a multi-level analysis of gene expression. Respiratory research\| PubMed ID: 41408261	2025
The 2026: towards the golden age of respiratory science? The European respiratory journal\| PubMed ID: 41611258	2026
Add-on LAMA therapy in asthma: an underused strategy for exacerbation prevention. The Lancet. Respiratory medicine\| PubMed ID: 41692018	2026
The vascular fingerprint of the lungs: why pulmonary vessel count matters in COPD. The European respiratory journal\| PubMed ID: 41786489	2026
What the BMI genes are telling us about COPD phenotypes: emphysema for the thin and airways disease for the heavy. Annals of the American Thoracic Society\| PubMed ID: 41837380	2026
COPD Action Plans: Gaps in Development Methods, Content, and Format. International journal of chronic obstructive pulmonary disease\| PubMed ID: 41878302	2026