ab-externo-canaloplasty-alone-or-combined-with-phacoemulsification

Ab Externo Canaloplasty Alone or Combined with Phacoemulsification for Advanced Primary Open-Angle Glaucoma

Advanced primary open-angle glaucoma (POAG) requires surgical strategies that achieve effective reduction of intraocular pressure (IOP) while preserving ...

Dalian Third People's Hospital Affiliated to Dalian University of Technology

Acute angle closure (AAC) is a sight-threatening ophthalmic emergency. However, it remains uncertain whether the incidence of AAC-related blindness has declined in recent years. This study aimed to provide a contemporary analysis of the rate, clinical characteristics, and management outcomes of AAC-related blindness in China.

Acute Angle Closure and Blindness in China: A Multicenter Retrospective Study on Treatment Effectiveness and Visual Outcomes.

Diabetic retinopathy (DR), the most prevalent ocular complication of diabetes, progresses from non-proliferative (NPDR) to sight-threatening proliferative (PDR) stages. Current interventions-including retinal photocoagulation, intravitreal anti-VEGF agents, and surgery-address advanced disease, often require repeated administration, and carry risks like retinal injury. Safer, more effective, and longer-lasting treatments are needed, especially for early-stage DR. Mesenchymal stem cells (MSCs) and their derivatives offer a promising alternative, with advantages including low immunogenicity, paracrine signaling, and the ability to mitigate inflammation and vascular permeability. However, challenges in delivery efficiency and targeting specificity remain. Hydrogel-based scaffold materials are increasingly important due to their superior biocompatibility and ability to overcome ocular barriers. Recent advances include novel injectable hydrogels that can be combined with drugs or stem cells, enabling targeted delivery to retinal layers, prolonging therapeutic retention, and significantly improving bioavailability for sustained treatment of DR.

Article	Year
Acute Angle Closure and Blindness in China: A Multicenter Retrospective Study on Treatment Effectiveness and Visual Outcomes. Ophthalmology. Glaucoma\| PubMed ID: 41628816	2026
Hydrogel-based delivery of MSCs and derivatives for improved diabetic retinopathy therapy. Stem cell research & therapy\| PubMed ID: 41862936	2026

Lijun Zhao

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