single-fiber-isolation-assay-for-assessment-oxidative-myofiber

Single Fiber Isolation Assay for the Assessment of Oxidative Myofiber Behavior

Skeletal muscle is composed of multinucleated myofibers whose integrity and function are essential for movement and overall health. In neuromuscular ...

integrative-analysis-targeted-genomic-profiling-immune-cell

Integrative Analysis of Targeted Genomic Profiling and Immune Cell Infiltration in the Prognosis of Lung Adenocarcinoma

The prognosis of lung adenocarcinoma (LUAD) is traditionally evaluated via tumor-node-metastasis (TNM) staging, which does not account for the ...

Tokyo Metropolitan University

Shanghai Fujun Genetics Co., Ltd

Myofibers are broadly classified as slow-twitch (Type I) and fast-twitch (Type II) fibers. These two types of myofibers coexist within the same skeletal muscle tissue, determining the contractile and metabolic properties of skeletal muscle tissue by fiber type distribution.

Myokine BDNF highly expressed in Type I fibers inhibits the differentiation of myotubes into Type II fibers.

This study aimed to compare the effects of ipsilateral electroacupuncture at the site of exercise-induced pain and those of contralateral electroacupuncture on delayed-onset muscle soreness, muscle injury markers, and oxidative stress after eccentric exercise.

Effect of Electroacupuncture on Delayed-Onset Muscle Soreness Induced by Eccentric Exercise in Young Untrained Men: Randomized Controlled Trial.

In recent years, skeletal muscle has been recognized not only as a locomotor organ but also as a secretory organ. The bioactive molecules it releases, known as myokines, act on distant organs through the circulation and locally on muscle tissue. Previously, we identified R-spondin 3 (Rspo3) as a Type I fiber-specific myokine that promotes myoblast differentiation into Type I fibers in vitro. In this study, we further investigated whether Rspo3 is involved in regulating Type I fiber determination in vivo.

ArticleTotal : 2	Year
Publication title	2026
Publication title	2026

Article	Year
Myokine BDNF highly expressed in Type I fibers inhibits the differentiation of myotubes into Type II fibers. Molecular biology reports\| PubMed ID: 39531063	2024
Effect of Electroacupuncture on Delayed-Onset Muscle Soreness Induced by Eccentric Exercise in Young Untrained Men: Randomized Controlled Trial. American journal of physical medicine & rehabilitation\| PubMed ID: 39937969	2025
R-spondin 3 is a myokine that mediates type I fiber determination during skeletal muscle regeneration. Molecular biology reports\| PubMed ID: 41065962	2025

Teng Hu

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