bioinformatics-identification-candidate-biomarkers-associated-with

Bioinformatics Identification of Candidate Biomarkers Associated with Periodontitis in Cytokine-Treated Periodontal Ligament Stem Cells

The primary objective of the current study was to investigate the potential molecular mechanism underlying cytokine-induced periodontal ligament stem ...

Heilongjiang Provincial Stomatological Disease Prevention and Treatment Hospital

To avoid apoptosis induced by reactive oxygen species (ROS), the tumor cells often activate the repair mechanism to repair the damaged DNA and by which maintain the stability and survival of cancer cells. Human MutT homolog 1 (MTH1) is an important oxidative DNA repair enzyme. TH287 is a highly effective inhibitor of MTH1 enzyme, which can induce cell apoptosis. Doxorubicin (DOX) primarily exerts its anticancer effects by inducing DNA damage via topoisomerase II inhibition and free radical generation in redox reactions. Therefore, the combination of DOX and TH287 may have a surprising anti-tumor effect. The optimal integration of nanomicelles with combination therapy promises to deliver an effective drug system with synergistic effects. In this investigation, we engineered pH-responsive nanomicelles utilizing HPAH to simultaneously deliver the chemotherapeutic drug DOX and the MTH1 inhibitor TH287 for the management of oral squamous cell carcinoma (OSCC).

Sequential release of MTH1 inhibitor and chemotherapeutic drug using a pH-sensitive polymeric delivery system induces apoptosis in human tongue squamous cell carcinoma CAL-27 cells in vitro.

Cuicui Yan

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