bioinformatics-identification-candidate-biomarkers-associated-with

Bioinformatics Identification of Candidate Biomarkers Associated with Periodontitis in Cytokine-Treated Periodontal Ligament Stem Cells

The primary objective of the current study was to investigate the potential molecular mechanism underlying cytokine-induced periodontal ligament stem ...

The first Affiliated Hospital of Harbin Medical University

Nonsyndromic cleft lip with or without cleft palate (NSCLP) has been recognized as a condition resulting from a combination of environmental and genetic factors. Studies have demonstrated that microRNAs (miRNAs) are involved in embryonic development. However, few studies have focused on screening potential target miRNAs in human NSCLP tissue. Using microarray-based miRNA expression profiling, miRNA expression was compared in tissue samples from 4 NSCLP patients and 4 healthy control subjects. Two hundred and fifty-four miRNAs were found to be differentially expressed. Changes in Homo sapiens (hsa)-miR-24-3p, hsa-miR-27b-3p, hsa-miR-205-5p, hsa-miR-1260b and hsa-miR-720 were of particular interest with respect to Wnt signaling (fold-changes were 12.5, 12.2, 12.1, 12.3 and 10.5, respectively; P<0.005 for all). The levels of hsa-miR-24-3p, hsa-miR-1260b and hsa-miR-205-5p were higher in tissues from NSCLP patients than in those from controls according to PCR analysis. Hsa-miR-24-3p, hsa-miR-1260b and hsa-miR-205-5p may be candidate miRNAs involved in the etiology of NSCLP via Wnt signaling.

A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate.

The research on the etiology of nonsyndromic cleft lip with or without cleft palate(NSCL/P) is challenging, and DNA methylation has an impact on the formation of cleft lip and palate.

Study on the role of methylation in nonsyndromic cleft lip with or without cleft palate using a monozygotic twin model.

The aim of this study was at investigating the association between major depressive disorder (MDD) and periodontitis based on crosstalk genes and neuropeptides.

Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder.

This investigation examined the effects of the microRNA miR-34c-5p on the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC) and the mechanisms involved.

miR-34c-5p mediates the cellular malignant behaviors of oral squamous cell carcinoma through targeted binding of TRIM29.

To avoid apoptosis induced by reactive oxygen species (ROS), the tumor cells often activate the repair mechanism to repair the damaged DNA and by which maintain the stability and survival of cancer cells. Human MutT homolog 1 (MTH1) is an important oxidative DNA repair enzyme. TH287 is a highly effective inhibitor of MTH1 enzyme, which can induce cell apoptosis. Doxorubicin (DOX) primarily exerts its anticancer effects by inducing DNA damage via topoisomerase II inhibition and free radical generation in redox reactions. Therefore, the combination of DOX and TH287 may have a surprising anti-tumor effect. The optimal integration of nanomicelles with combination therapy promises to deliver an effective drug system with synergistic effects. In this investigation, we engineered pH-responsive nanomicelles utilizing HPAH to simultaneously deliver the chemotherapeutic drug DOX and the MTH1 inhibitor TH287 for the management of oral squamous cell carcinoma (OSCC).

Sequential release of MTH1 inhibitor and chemotherapeutic drug using a pH-sensitive polymeric delivery system induces apoptosis in human tongue squamous cell carcinoma CAL-27 cells in vitro.

This study aims to investigate the relationship between the expression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) and the development of oral squamous cell carcinoma (OSCC).

Article	Year
A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate. Experimental and therapeutic medicine\| PubMed ID: 28565881	2017
Study on the role of methylation in nonsyndromic cleft lip with or without cleft palate using a monozygotic twin model. International journal of pediatric otorhinolaryngology\| PubMed ID: 33667834	2021
Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder. Disease markers\| PubMed ID: 34721734	2021
miR-34c-5p mediates the cellular malignant behaviors of oral squamous cell carcinoma through targeted binding of TRIM29. Annals of translational medicine\| PubMed ID: 34790743	2021
Sequential release of MTH1 inhibitor and chemotherapeutic drug using a pH-sensitive polymeric delivery system induces apoptosis in human tongue squamous cell carcinoma CAL-27 cells in vitro. World journal of surgical oncology\| PubMed ID: 41121313	2025
CIAPIN1 as a Promoter of Oral Squamous Cell Carcinoma Progression. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology\| PubMed ID: 41189039	2026

Changsheng Sun

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