longitudinal-evaluation-auditory-speech-performance-pediatric

Longitudinal Evaluation of Auditory and Speech Performance in Pediatric Cochlear Implant Recipients Using IT-MAIS, MESP, CAP, and SIR Scales

Considerable variability in auditory and speech outcomes among pediatric cochlear implant (CI) recipients has raised ongoing debate regarding whether ...

Central South University (Hunan Children's Hospital)

Intranasal corticosteroids are the most efficacious anti-inflammatory medications for allergic rhinitis (AR). However, the efficacy and safety of intranasal corticosteroids in children have not yet been subject to specific research in China. The aim of this study was to investigate the efficacy and safety of fluticasone furoate nasal spray (FFNS) in a Chinese pediatric population.

Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study.

Mast cell (MC)-mediated inflammation is essential for allergic rhinitis, and nuclear factor E2 related factor (NRF2) is found to inhibit inflammation. This study investigated whether NRF2 could inhibit MC inflammation and its molecular mechanisms concerning SIRT4.

Nuclear factor E2 related factor (NRF2) inhibits mast cell- mediated allergic inflammation via SIRT4-mediated mitochondrial metabolism.

Long noncoding RNA nuclear enriched abundant transcript 1 (lnc-NEAT1) and its target microRNA-125a (miR-125a) are reported to regulate immune and inflammation process in allergic rhinitis (AR). Hence, this study intended to investigate the correlation between lnc-NEAT1 and miR-125a expressions, as well as their clinical values in pediatric AR patients.

Aberrant expressions of circulating lncRNA NEAT1 and microRNA-125a are linked with Th2 cells and symptom severity in pediatric allergic rhinitis.

To explore the effect of the caregiver's knowledge, behaviour and attitude on the prevention of foreign bodies in children's respiratory tracts to provide a basis for publicity and education on foreign bodies in children's respiratory tracts.

Prevention of foreign bodies entering Children's respiratory tracts: The effect of the Caregiver's knowledge, behaviour and attitude.

Allergic rhinitis (AR) threatens patient survival. CD4 T cells play key roles in AR progression. Long non-coding RNAs (lncRNAs) are key regulators of cell differentiation. Therefore, we investigated the molecular mechanism of the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in AR. Expression levels of MALAT1, microRNA (miR)-135b-5p, interleukin-4 (IL-4), and GATA-binding protein 3 (GATA-3) in the nasal mucosa of AR patients were quantified. CD4 T cells were isolated from the peripheral blood of healthy volunteers and treated with ovalbumin (OVA) and Th2 inducers. After MALAT1 and miR-135b-5p levels changed in CD4 T cells, the proportion of IL-4-expressing cells and the levels of IL-4 and GATA-3 in OVA-induced CD4 T cells were determined. Binding relationships among MALAT1, miR-135b-5p, and GATA-3 were predicted and verified. Rescue experiments were performed to confirm the role of the MALAT1/miR-135b-5p/GATA-3 axis in Th2 differentiation of CD4 T cells. MALAT1, IL-4, and GATA-3 expression was upregulated, whereas miR-135b-5p expression was downregulated, in patients with AR. MALAT1 knockdown or miR-135b-5p overexpression in CD4 T cells notably decreased the proportion of IL-4-expressing cells and downregulated GATA-3 and IL-4 expression in OVA-induced CD4 T cells. MALAT1 and GATA-3 exhibited competitive binding toward miR-135b-5p. MALAT1 facilitated CD4 T cell Th2 differentiation via the miR-135b-5p/GATA-3 axis. MALAT1 facilitated AR development by facilitating CD4 T cell Th2 differentiation via the miR-135b-5p/GATA-3 axis. This study may provide guidance for clinical treatment of AR.

Long non-coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA-135b-5p/GATA-3 axis in children with allergic rhinitis.

The study aimed to assess the incidence of post-coblation tonsillectomy hemorrhage (PCTH) and identify associated risk factors in a pediatric Chinese population.

Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study.

To determine the prevalence of hearing impairment in neonates and identify associated risk factors through auditory brainstem response (ABR) screening.

Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening.

This study aims to investigate the clinical characteristics of congenital microtia, providing valuable insights for its diagnosis and treatment.

Article	Year
Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study. Pediatric research\| PubMed ID: 33007780	2021
Nuclear factor E2 related factor (NRF2) inhibits mast cell- mediated allergic inflammation via SIRT4-mediated mitochondrial metabolism. Annals of palliative medicine\| PubMed ID: 33222465	2020
Aberrant expressions of circulating lncRNA NEAT1 and microRNA-125a are linked with Th2 cells and symptom severity in pediatric allergic rhinitis. Journal of clinical laboratory analysis\| PubMed ID: 35064698	2022
Prevention of foreign bodies entering Children's respiratory tracts: The effect of the Caregiver's knowledge, behaviour and attitude. International journal of pediatric otorhinolaryngology\| PubMed ID: 35961061	2022
Long non-coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA-135b-5p/GATA-3 axis in children with allergic rhinitis. The Kaohsiung journal of medical sciences\| PubMed ID: 36149748	2022
Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\| PubMed ID: 39714620	2025
Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening. Journal of multidisciplinary healthcare\| PubMed ID: 40357256	2025
Clinical Characteristics, Concomitant Malformations and Hearing Status in Congenital Microtia - A Retrospective Analysis of 635 Cases. American journal of otolaryngology\| PubMed ID: 40381487	2025

Sijun Zhao

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