individualized-periprocedural-management-congenital-dysfibrinogenemia

Individualized Periprocedural Management of Congenital Dysfibrinogenemia during Transvaginal Oocyte Retrieval: A Case Report

Congenital dysfibrinogenemia is a qualitative fibrinogen disorder with phenotypes ranging from isolated laboratory abnormalities to bleeding or ...

The Reproductive Hospital of Guangxi Zhuang Autonomous Region

Despite substantial resources deployed to curb SARS-CoV-2 transmission, controlling the COVID-19 pandemic has been a major challenge. New variants of the virus are frequently emerging leading to new waves of infection and re-introduction of control measures. In this study, we assessed the effectiveness of containment strategies implemented in the early phase of the pandemic.

Effectiveness of containment strategies in preventing SARS-CoV-2 transmission.

Recurrence of postoperative adhesions is one of the most important factors for poor reproductive outcomes after hysteroscopic surgery, particularly in cases diagnosed with severe intrauterine adhesions (IUAs), where the recurrence rate is significantly higher. This study aims to explore the effectiveness of the electrical muscle stimulation combined with ultrasound acupuncture therapy in preventing the recurrence of IUAs and improving reproductive outcomes after operative hysteroscopy.

Efficacy of electrical stimulation combined with ultrasound acupuncture therapy on treatment in patients with intrauterine adhesions: Study protocol for a placebo-controlled, single-blind, single-center, randomized trial.

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that negatively affects female reproductive capacity. Although the association between autophagy and PCOS is known, there are few detailed studies on the association between autophagy-related genes and PCOS.

Elucidating the Role of Autophagy-related Genes in Polycystic Ovary Syndrome: Implications for Diagnostic Models and Immune Response Regulation.

Regarding "A Comparative Study on the Efficacy of Subendometrial Versus Intrauterine Platelet-Rich Plasma Injections for Treating Intrauterine Adhesions: A Retrospective Cohort Study".

Cervical cancer (CC) is the fourth leading cause of cancer-related death in women globally.While early screening has reduced mortality, tumor metastasis remains a significant concern, particularly in developing countries. Recent studies have identified cuproptosis, a copper-dependent cell death mechanism, as a potential factor in tumor progression. Long non-coding RNAs (lncRNAs) are key regulators of tumor progression. This study investigates the role of cuproptosis-related lncRNA (CRL) CNNM3-DT in CC, focusing on its impact on LIAS expression, intracellular copper levels, and tumor progression.

Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels.

The aim of this study is to investigate the expression patterns and regulatory functions of Copines family genes in different cellular subpopulations in testicular cancer based on single-cell data and to analyze the regulatory mechanism of Copines family genes in cancer.

Single-cell RNA Sequencing Analysis Reveals the Regulatory Functions of Copines Family Genes in Testicular Cancer Progression.

Globally, infertility affects 10-15% of couples, with Fallopian Tube Obstruction (FTO) being a principal cause. Current therapeutic options are inadequate, prompting a demand for effective, less invasive treatments with lower recurrence.

Exploratory study on the application of laser-induced cavitation bubble in the treatment of fallopian tube obstruction.

Clinically, it has been observed that vaginal administration of the same dose of Micronized 17-beta estradiol hemihydrate (the Estradiol tablets of Femoston) significantly increases serum estradiol levels compared to oral administration. However, the clinical outcomes associated with this route of administration remain unclear. Additionally, the concentration of estradiol in endometrial tissue following vaginal administration of Micronized 17-beta estradiol hemihydrate (M17EH), as well as its potential impact on endometrial receptivity, has been poorly investigated.

Clinical outcomes of different 17β-estradiol drug regimens and their impact on endometrial receptivity.

Per- and polyfluroroalkyl substances (PFAS) are potential endocrine disruptors, but their associations with reproductive hormones remain inconsistent, and evidence linking PFAS in ovarian follicular fluid (FF) to hormones is limited. In this study, we investigated these associations among 501 women undergoing in vitro fertilization (IVF) treatment from the GIVES cohort, with PFAS levels measured in follicular fluid from all participants and in serum from a subset of 410 women. Serum samples were collected on menstrual cycle days 2-5 and the ovulation trigger day for hormone measurement, and PFAS levels were assessed in FF and serum. We found distinct associations between PFAS in FF and serum with reproductive hormones. For example, the highest quartile of FF 6:2 Cl-PFESA was negatively associated with basal luteinizing hormone (LH) (β = -0.13, 95 %CI: 0.23, -0.02), while that of serum 6:2 Cl-PFESA was positively associated with basal LH (β = 0.13, 95 %CI: 0.01, 0.25), compared to the lowest quartile. Additionally, significant associations were identified between certain PFAS and hormones following controlled ovarian stimulation. Bayesian Kernel Machine Regression models indicated a negative association between a mixture of nine FF PFAS and basal follicle stimulating hormone. These findings provide new insights into PFAS exposure and female reproductive hormones, highlighting the importance of measuring PFAS in multiple biological matrices to comprehensively assess their effects on ovarian health.

Article	Year
Effectiveness of containment strategies in preventing SARS-CoV-2 transmission. Journal of infection and public health\| PubMed ID: 35537237	2022
Efficacy of electrical stimulation combined with ultrasound acupuncture therapy on treatment in patients with intrauterine adhesions: Study protocol for a placebo-controlled, single-blind, s... Medicine\| PubMed ID: 36550829	2022
Elucidating the Role of Autophagy-related Genes in Polycystic Ovary Syndrome: Implications for Diagnostic Models and Immune Response Regulation. Current medicinal chemistry\| PubMed ID: 39421991	2025
Regarding "A Comparative Study on the Efficacy of Subendometrial Versus Intrauterine Platelet-Rich Plasma Injections for Treating Intrauterine Adhesions: A Retrospective Cohort Study". Journal of minimally invasive gynecology\| PubMed ID: 40164428	2025
Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels. Frontiers in oncology\| PubMed ID: 40265013	2025
Single-cell RNA Sequencing Analysis Reveals the Regulatory Functions of Copines Family Genes in Testicular Cancer Progression. Endocrine, metabolic & immune disorders drug targets\| PubMed ID: 40337972	2026
Exploratory study on the application of laser-induced cavitation bubble in the treatment of fallopian tube obstruction. PloS one\| PubMed ID: 40445904	2025
Clinical outcomes of different 17β-estradiol drug regimens and their impact on endometrial receptivity. Frontiers in endocrinology\| PubMed ID: 41113716	2025
Differential associations of PFAS in follicular fluid and serum with reproductive hormones: Insights from a Chinese IVF cohort GIVES. Environmental research\| PubMed ID: 41177354	2026

Xuehong Zhu

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